Neurodegenerative Disease News and Research

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New ray of hope for children with Batten disease

Investigators at the University of Rochester Medical Center have uncovered a promising drug therapy that offers a ray of hope for children with Batten disease

13 Dec 2007

Scientists characterize Alzheimer's neurotoxin structure - potential new treatment approaches

Amyloid plaques, the hallmark of Alzheimer's disease, are clumps of fiber-like misfolded proteins which many experts think cause this devastating neurodegenerative disease.

4 Dec 2007

Peptide therapy used to prevent progression of Parkinson's

Researchers have successfully used a peptide to reverse biochemical, cellular and anatomical changes that occur in the brains of mice with Parkinson's disease (PD), and report success in preventing the disease from progression.

21 Nov 2007

New study finds blood-spinal cord barrier compromised in mice with ALS

The blood-spinal cord barrier is functionally impaired in areas of motor neuron damage in mice modeling amyotrophic lateral sclerosis (ALS), report researchers at the University of South Florida Center for Aging and Brain Repair.

21 Nov 2007

Biomarkers for Alzheimer's can be trusted in clinical trials

The best-established biomarkers for Alzheimer’s disease have a low natural variation over two years. The results speak for the inclusion of these biomarkers in clinical trials of novel drugs against Alzheimer’s disease.

16 Nov 2007

Overexpression of neuroglobin reduces severity of Alzheimer's disease in mice

Mice genetically engineered to both overproduce the protein neuroglobin and to develop Alzheimer's disease (AD) had a much milder form of the disease when compared to mice engineered to have AD alone, researchers at the Buck Institute for Age Research have reported.

13 Nov 2007

Lithium commonly used to treat bi-polar disorder increases lifespan in Nematode worms

Nematode worms treated with lithium show a 46 percent increase in lifespan, raising the tantalizing question of whether humans taking the mood affecting drug are also taking an anti-aging medication.

31 Oct 2007

Risk factors that may contribute to the onset of Amyotrophic Lateral Sclerosis

Researchers in Rensselaer Polytechnic Institute's Social and Behavioral Research Lab (SBRL) are leading a study to investigate potential environmental, lifestyle, and medical variables that may contribute to the onset of Amyotrophic Lateral Sclerosis (ALS).

29 Oct 2007

Scientists use shared genome data to confirm SORL1 gene linked to Alzheimer's

Until recently, only one of the approximately 30,000 genes in the human genome has been linked to risk of late-onset Alzheimer's disease (AD).

29 Oct 2007

Valsartan might help prevent Alzheimer's disease

Alzheimer disease (AD), a neurodegenerative disease that is the most common form of dementia, is characterized by the formation in the brain of plaques containing misfolded beta-amyloid protein.

25 Oct 2007

Cancer researchers investigate free radicals

The University of Leicester has been selected as the hub of a worldwide network of researchers to investigate one of the causes of cancer.

11 Oct 2007

Discovery offers hope of halting motor neurone disease progression

Scientists have discovered a causal link between the gene for a small protein involved in the formation of blood vessels and the development of some forms of motor neurone disease.

4 Oct 2007

Tree bark compound gambogic amide stimulates growth, survival of brain cells

Researchers have identified a compound in tree bark that mimics the chemical reactions of a naturally occurring molecule in the brain responsible for stimulating neuronal cell signaling.

2 Oct 2007

Discovery of new pathway causing cell death related to frontotemporal dementia and ALS

Scientists have discovered a link between a mutated gene and a protein found in dead brain cells of people who suffer from a form of dementia and other neurological disorders.

27 Sep 2007

New cell death pathway involved in sperm development

Heavy and bulky sperm would not be good swimmers. To trim down, sperm rely on cell death proteins called caspases, which facilitate the removal of unwanted cellular material and radically remodel these cells into their sleek, light shape.

18 Sep 2007

New guidelines to diagnose Alzheimer's disease

Physicians may be able to detect and treat Alzheimer's Disease (AD) in its earliest stages, when patients are experiencing only mild degrees of cognitive impairment, thanks to new diagnostic criteria proposed by an international group of researchers.

18 Sep 2007

New insight into the mechanisms of Lou Gehrig's disease

There is no known cure for amyotrophic lateral sclerosis (ALS), often known as Lou Gehrig disease and motor neuron disease.

13 Sep 2007

Low level of neuronal receptor LR11 linked to Alzheimer's disease

Results of a new study indicate a strong link between the loss of the neuronal receptor LR11and onset of mild cognitive impairment (MCI), often a harbinger of Alzheimer's disease.

5 Sep 2007

Proteins involved in fragile X syndrome identified

The interplay of two proteins that bind to messenger RNA, a molecule that mediates translation of the information encoded in genes into proteins, triggers the appearance of fragile X-associated tremor/ataxia syndrome (FTAX), a late-life disorder associated with the gene that causes fragile X syndrome in children, said researchers from Baylor College of Medicine in Houston and Emory University School of Medicine in a report that appears today in the journal Neuron.

17 Aug 2007

Overexposure to metals and Alzheimer's disease

A multi-institutional team of researchers led by Emory University has defined for the first time how metal ions bind to amyloid fibrils in the brain in a way that appears toxic to neurons.

7 Aug 2007