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Cocaine induces abnormal enhancement of neuronal connections

Researchers working with rats have zeroed in on the brain circuitry mechanism whose disruption contributes to the impulsive behavior seen in users of cocaine as well as other psychostimulant drugs. The same circuitry has been implicated in such disorders as schizophrenia, depression, and post-traumatic stress disorder, wrote the researchers.

21 Jul 2005

Definitive proof that Ab42 is the culprit molecule that underlies the pathology of Alzheimer's disease

One puzzle in Alzheimer's disease (AD) research is why mice engineered to have the abnormal protein underlying the disease in humans show little pathology of the disease. Specifically, such mice are genetically altered to overproduce mutant human amyloid precursor protein (APP).

21 Jul 2005

New research suggests that accumulation of amyloid-beta peptides in cerebral blood vessels causes vascular damage in Alzheimer's disease

New research suggests that accumulation of amyloid-â peptides in cerebral blood vessels, as opposed to the brain itself, may be a more important pathological mediator of Alzheimer's disease. Two independent yet related articles describe such findings in the August issue of The American Journal of Pathology.

21 Jul 2005

Hormonal signaling systems and their role in sex drive

Two University of Edinburgh professors from the Centre for Integrative Physiology describe how "our understanding of how the brain processes information is undergoing a radical shift as we begin to recognize the implications of hormonal signaling systems within the brain itself," explained Gareth Leng.

19 Jul 2005

Researchers have identified a protein that is crucially involved in how our memories are stored and processed

University of Queensland researchers have identified a protein that is crucially involved in how our memories are stored and processed, paving the way for new strategies to treat conditions certain mental disorders.

18 Jul 2005

Nerve cells can also release neurotransmitters outside of synapses

Every neurobiology textbook invariably states that nerve cells communicate with each other through synapses, the specialized cell-cell contacts found at the end of the cells' threadlike extensions. In the journal Science, researchers at the Salk Institute for Biological Sciences and the University of California at San Diego report that nerve cells, or neurons, may not have to rely on traditionally defined synapses to "talk" to each other.

18 Jul 2005

Novel way in which the brain size of developing mammals may be regulated

Howard Hughes Medical Institute researchers have discovered a novel way in which the brain size of developing mammals may be regulated. They have identified a signaling pathway that controls the orientation in which dividing neural progenitor cells are cleaved during development.

14 Jul 2005

Important role of early experience in shaping neuronal development

Scientists at New York University School of Medicine reveal the important role of early experience in shaping neuronal development and brain plasticity in a new study published in the July 14 issue of the journal Nature.

14 Jul 2005

Single mutation in a human sodium channel gene can trigger pain in people with primary erythromelalgia

Yale School of Medicine researchers report the first demonstration that a single mutation in a human sodium channel gene can trigger pain in people with an inherited pain syndrome known as primary erythromelalgia, according to a study published this month in the journal Brain.

13 Jul 2005

Scientists reveal the important role of early experience in shaping neuronal development

13 Jul 2005

Serotonin may play a role in maintaining circadian rhythm

Researchers at the University of Pennsylvania School of Medicine have determined how serotonin decreases the body's sensitivity to light and that exposure to constant darkness leads to a decrease in serotonin levels in the brain of fruit flies.

12 Jul 2005

New insights into brain cell metabolism from PET and MRI scans

By discovering a crucial piece of submicroscopic information about how the brain converts fuel into energy for neurons, Cornell University biophysicists have gleaned new insights into brain cell metabolism that will allow neurologists to better interpret data from such diagnostic tests as positron emission tomography (PET) scans and a specialized magnetic resonance imaging (MRI) test.

12 Jul 2005

Possible cure for Huntington's disease

Boosting levels of two critical proteins that normally shut down during Huntington's disease, researchers at the University of Wisconsin-Madison and the Cold Spring Harbor Laboratory have cured fruit flies of the genetic, neurodegenerative condition.

12 Jul 2005

Overactive dopamine receptors may help explain anorexia nervosa symptoms

Just why those with anorexia nervosa are driven to be excessively thin and seem unaware of the seriousness of their condition could be due to over-activity of a chemical system found in a region deep inside the brain, a University of Pittsburgh study suggests.

11 Jul 2005

Researchers find molecule ephrin-B3 inhibits regrowth of spinal nerve cells

A molecule that helps the body's motor nerve cells grow along proper paths during embryonic development also plays a major role in inhibiting spinal-cord neurons from regenerating after injury, researchers at UT Southwestern Medical Center have found.

11 Jul 2005

Dopamine agonist therapy for Parkinson's disease may lead to problem gambling

Eleven patients with Parkinson's disease (PD) developed pathological gambling behavior following dopamine agonist therapy, a drug therapy to control movement problems caused by Parkinson's disease, according to a study posted online which will appear in the September print issue of Archives of Neurology.

11 Jul 2005

New roles for granulocyte colony-stimulating factor (G-CSF) in treating stroke

In a study appearing online on July 7 in advance of print publication of the August 1 issue of the Journal of Clinical Investigation, Armin Schneider and colleagues from Axaron Biosciences describe new roles for granulocyte colony-stimulating factor (G-CSF) in treating stroke and other central nervous system roles of this protein.

11 Jul 2005