Neuroscience News and Research

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Alectos Therapeutics collaborates with Merck for Alzheimer’s disease research

Alectos Therapeutics Inc. today announced a research collaboration with Merck, headquartered in Whitehouse Station, N.J., to identify and develop compounds that modulate O-linked N-acetylglucosaminidase (O-GlcNAcase) an enzyme that is believed to be involved in the development of Alzheimer's disease and potentially other disorders. The agreement provides Merck with a worldwide, exclusive license to research, develop and commercialize compounds that modulate this target.

12 Aug 2010

Elan to offer $200 million in aggregate principal amount of 8.75% senior notes due 2016

Elan Corporation, plc today announced that its wholly-owned subsidiaries, Elan Finance public limited company and Elan Finance Corp., intend to offer, subject to market conditions, US$200 million in aggregate principal amount of 8.75% senior notes due 2016.

11 Aug 2010

Study finds 'grid cells' that help brain map locations outside hippocampus

"Grid cells," which help the brain map locations, have been found for the first time outside of the hippocampus in the rat brain, according to new research from the Norwegian University of Science and Technology (NTNU). The finding should help further our understanding of how the brain generates the internal maps that help us remember where we have been and how to get to where we want to go.

10 Aug 2010

Transcept Pharmaceuticals second-quarter net loss decreases to $2.06 million

Transcept Pharmaceuticals, Inc., a specialty pharmaceutical company focused on the development and commercialization of proprietary products that address important therapeutic needs in the field of neuroscience, today announced financial results for the three and six months ended June 30, 2010.

10 Aug 2010

Elan and Transition Therapeutics report results of ELND005 Phase 2 study for Alzheimer's disease

Elan Corporation, plc and Transition Therapeutics, Inc today announced the results of a Phase 2 placebo-controlled study in 351 patients with mild to moderate Alzheimer's disease who received study drug for up to 18 months (Study AD201). Study subjects with MMSE scores between 16 and 26 received ELND005 oral doses of 250 mg, 1000 mg or 2000 mg twice daily or matching placebo. The study's cognitive (NTB) and functional (ADCS-ADL) co - primary endpoints did not achieve statistical significance.

10 Aug 2010

Loyola University forms new institute for molecular level disease research

Loyola University Chicago Stritch School of Medicine has formed a new research institute dedicated to understanding the molecular causes of cancer, autoimmune disorders, cardiovascular disease and several other illnesses.

10 Aug 2010

Study to evaluate sensitivity of mammography combined with somo•v ABUS technology in breast cancer screening

Henry Ford West Bloomfield Hospital announced today that it has joined U-Systems national clinical research study designed to evaluate whether digital mammography, when combined with the somo•v Automated Breast Ultrasound System (ABUS) from U-Systems, Inc (Sunnyvale, CA), is more sensitive in detecting breast lesions compared to mammography alone in women with dense breasts. Henry Ford West Bloomfield Hospital is the only site in Michigan, and one of only ten breast cancer centers in the entire country, currently recruiting women for the SOMO•INSIGHT clinical study.

10 Aug 2010

UCLA study identifies neurocognitive pathways involved in inflammatory responses to acute social stress

Everyone experiences social stress, whether it is nervousness over a job interview, difficulty meeting people at parties, or angst over giving a speech. In a new report, UCLA researchers have discovered that how your brain responds to social stressors can influence the body's immune system in ways that may negatively affect health.

10 Aug 2010

AstraZeneca reaches agreements in principle on monetary terms for SEROQUEL product liability

AstraZeneca announced today that, as of August 9, it had reached agreements in principle on monetary terms with attorneys representing approximately 17,500 SEROQUEL product liability claimants in the United States for approximately $198 million. The agreements in principle are subject to agreement on non-monetary terms.

9 Aug 2010

Scientists induce nerve tissue regeneration in patients with spinal cord injury

Researchers for the first time have induced robust regeneration of nerve tissue connections in injured adult spinal cord sites that control voluntary movement. These findings provide hope that it may be possible to design therapies for paralysis and other impairments of motor function arising from spinal cord injury.

9 Aug 2010

FDA confirms Advisory Committee meeting date for lorcaserin NDA review

Arena Pharmaceuticals, Inc. and Eisai Inc. announced today that the US Food and Drug Administration (FDA) has notified the company of the confirmed scheduling of an Endocrinologic and Metabolic Drugs Advisory Committee meeting on September 16, 2010, for the review of the lorcaserin New Drug Application (NDA). Lorcaserin, which Arena discovered and has developed for weight management, is intended for obese patients as well as overweight patients who have at least one weight-related co-morbid condition.

7 Aug 2010

Drugs that reduce activity of ABDH6 enzyme can prevent brain damage: Study

A newly discovered molecular mechanism helps control the amount and effectiveness of a substance that mimics an active ingredient in marijuana, but that is produced by the body's own nerve cells.

7 Aug 2010

UC Riverside scientists secure grants for tobacco control research

Tobacco-related disease kills more people worldwide than any other single factor. To help address this problem, the University of California, Riverside has received six grants from the University of California Tobacco-Related Disease Research Program (TRDRP), the most TRDRP grants the campus has received in any year.

6 Aug 2010

TEMPO study recommends early administration of Azilect in PD patients

Teva Pharmaceutical Industries Ltd. and H. Lundbeck A/S (Lundbeck) today announced newly published long-term data on Azilect(rasagiline tablets) from the TEMPO study and its open-label extension. The findings confirm the long-term efficacy, safety and tolerability of Azilect® in patients with Parkinson's disease (PD) and further demonstrate the benefits obtained with early treatment initiation. The data was published in the June 2010 issue of the International Journal of Neuroscience.

6 Aug 2010

New studies question wide-spread hypothesis that CCSVI contribute to development of MS

Researchers at Umeå University in Sweden have performed a study that indicates that neither blood flow nor the flow of spinal fluid in the brain contribute to the development of multiple sclerosis, MS. The findings run directly counter to a much-discussed and widely spread Italian theory.

5 Aug 2010

Genomic sequence of living marine sponge reveals some basic information about cancer: Scientists

This week's publication of the complete genomic sequence of a living marine sponge reveals genes dating back hundreds of millions of years -- a result far exceeding the expectations of the scientific world.

5 Aug 2010

Posterior parietal cortex brain activity linked with subjects’ performance perceptions

Our belief as to whether we will likely succeed or fail at a given task-and the consequences of winning or losing-directly affects the levels of neural effort put forth in movement-planning circuits in the human cortex, according to a new brain-imaging study by neuroscientists at the California Institute of Technology.

5 Aug 2010

University of Pennsylvania announces recipients of 2010 Templeton Positive Neuroscience Awards

The Positive Psychology Center of the University of Pennsylvania and the John Templeton Foundation have announced the recipients of the 2010 Templeton Positive Neuroscience Awards, $2.9 million given to 15 new research projects at the intersection of neuroscience and positive psychology.

5 Aug 2010

Injecting PAP may reduce chronic pain: Research

A study published in the Aug. 4, 2010 issue of the Journal of Neuroscience introduces an enzyme that could pack a big punch in the battle against chronic pain. Its name is prostatic acid phosphatase or PAP for short. According to researchers at the University of North Carolina at Chapel Hill, PAP blocks pain in animal models by siphoning off a molecule called PIP2—a critical component of the chemical cascade behind chronic pain.

5 Aug 2010

Scientists discover Deep Brain Stimulation as potential treatment for early Alzheimer's

In a world first, Dr. Andres M. Lozano and his team at Toronto Western Hospital has shown using Deep Brain Stimulation (DBS) on patients with early signs of Alzheimer's disease is safe and may help improve memory. The phase one safety trial of six Ontario patients took place from 2005 to 2008. All patients left hospital within 2 to 3 days of surgery, and continue to participate in regular follow-up cognitive assessments.

5 Aug 2010

Neuroscience News and Research

Alectos Therapeutics collaborates with Merck for Alzheimer’s disease research

Elan to offer $200 million in aggregate principal amount of 8.75% senior notes due 2016

Study finds 'grid cells' that help brain map locations outside hippocampus

Transcept Pharmaceuticals second-quarter net loss decreases to $2.06 million

Elan and Transition Therapeutics report results of ELND005 Phase 2 study for Alzheimer's disease

Loyola University forms new institute for molecular level disease research

Study to evaluate sensitivity of mammography combined with somo•v ABUS technology in breast cancer screening

UCLA study identifies neurocognitive pathways involved in inflammatory responses to acute social stress

AstraZeneca reaches agreements in principle on monetary terms for SEROQUEL product liability

Scientists induce nerve tissue regeneration in patients with spinal cord injury

FDA confirms Advisory Committee meeting date for lorcaserin NDA review

Drugs that reduce activity of ABDH6 enzyme can prevent brain damage: Study

UC Riverside scientists secure grants for tobacco control research

TEMPO study recommends early administration of Azilect in PD patients

New studies question wide-spread hypothesis that CCSVI contribute to development of MS

Genomic sequence of living marine sponge reveals some basic information about cancer: Scientists

Posterior parietal cortex brain activity linked with subjects’ performance perceptions

University of Pennsylvania announces recipients of 2010 Templeton Positive Neuroscience Awards

Injecting PAP may reduce chronic pain: Research

Scientists discover Deep Brain Stimulation as potential treatment for early Alzheimer's

Neuroscience - Second Edition eBook

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Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

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