Nitric Oxide News and Research

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Scientists investigate health benefits of molecule associated with male sexual arousal

Medical scientists at the University of Leicester are investigating how signalling molecules known to control blood pressure and penile erection act to regulate brain function and which have potential for treatments of migraine, chronic pain, epilepsy and Alzheimer's disease.

24 Jun 2009

Novel light-sensitive compounds show promise for photodynamic cancer therapy

Chemists at the University of California, Santa Cruz, have developed novel compounds that show promise for photodynamic cancer therapy, which uses light-activated drugs to kill tumor cells.

17 Jun 2009

Being overweight or obese does not worsen asthma, but may reduce response to medications

Being overweight or obese does not make asthma worse in patients with mild and moderate forms of the disease, according to a study by National Jewish Health researchers, although it may reduce the response to medications.

3 Jun 2009

Discovery of enzyme involved in inflammatory bowel disease

Researchers at Penn State College of Medicine, working with biochemists, geneticists and clinicians at the University of Bern, Switzerland and in the United Kingdom, have discovered an enzyme that has a key role in inflammatory bowel disease (IBD).

2 Jun 2009

Clues about how blood forms could yield new strategies for treating blood diseases

Biologists have long wondered why the embryonic heart begins beating so early, before the tissues actually need to be infused with blood.

13 May 2009

New evidence of how high glucose damages blood vessels could lead to new diabetes treatments

New evidence of how the elevated glucose levels that occur in diabetes damage blood vessels may lead to novel strategies for blocking the destruction, Medical College of Georgia researchers say.

12 May 2009

Obstructive sleep apnea increases risk of heart and vascular disease

Obstructive sleep apnea, or periodic interruptions in breathing throughout the night, thickens sufferers' blood vessels. Moreover, it increases the risk of several forms of heart and vascular disease.

4 May 2009

Nanoparticles applied to skin offer hope for erection problems

Cutaneous application of nanoparticles may offer a new means of delivering drugs to treat erectile dysfunction (ED), according to findings presented at the 104th Annual Scientific Meeting of the American Urological Association (AUA).

26 Apr 2009

Alzheimer's disease linked to mitochondrial damage

Investigators at the Burnham Institute for Medical Research (Burnham) have demonstrated that attacks on the mitochondrial protein Drp1 by the free radical nitric oxide-which causes a chemical reaction called S-nitrosylation-mediates neurodegeneration associated with Alzheimer's disease.

5 Apr 2009

Electroacupuncture protects acetylsalicylic acid-induced acute gastritis in rats

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as anti-inflammatory and analgesic agents.

2 Apr 2009

Aerovance starts phase IIb clinical trial with Aerovant for uncontrolled asthma

Aerovance Inc. announced that it has received clearance from the U.S. Food and Drug Administration (FDA) and the U.K. Medicines and Healthcare products Regulatory Agency (MHRA) to initiate Aerovance's Phase IIb clinical trial, AeroTrial, of inhaled dry powder Aerovant in patients with uncontrolled asthma.

2 Apr 2009

Missing enzyme GNSOR conveys major heart protection in pre-clinical work

Mice born without a certain enzyme can resist the normal effects of a heart attack and retain nearly normal function in the heart's ventricles and still-oxygenated heart tissue, according to a study by researchers at Duke University Medical Center.

30 Mar 2009

Gilead commences phase II trial of Cicletanine for pulmonary arterial hypertension

Gilead Sciences, Inc. has announced that it has begun enrolling patients in a Phase II clinical trial of cicletanine hydrochloride (cicletanine), an oral agent in development for the treatment of pulmonary arterial hypertension (PAH).

24 Mar 2009

Coenzyme rare to bacteria critical to Mycobacterium tuberculosis survival

Coenzyme F420, a small molecule that helps certain enzymes transfer electrons, is found in microorganisms known as methane-producing archaea, some of which thrive in extreme environments.

23 Mar 2009

Male diabetics found to have lower levels of hydrogen sulfide in their blood

Hydrogen sulfide (H2S) is commonly associated with smell of rotten eggs, stink bombs and blocked drains but lower blood levels of the gas are possibly linked to cardiovascular complications in some male patients with type II diabetes, according to research recently presented by researchers at the Peninsula Medical School in the South West of England at the Annual Diabetes UK Professional Conference in Glasgow this week and published in Diabetic Medicine.

16 Mar 2009

Stem cell infusion and hyperbaric oxygen treatment improve islet function in diabetes

A study to determine if patients with type 2 diabetes can benefit from a combination of autologous (patient self-donated) stem cell infusions (ASC) and hyperbaric (above the normal air pressure of ) oxygen treatment (HBO) before and after ASC has found "significant benefits" in terms of "improvements in glycemic control" along with "reduced insulin requirements."

12 Mar 2009

Estrogen activates critical lung genes to improve lung function following preterm birth

Estrogen may be a new postnatal therapy to improve lung function and other outcomes in preterm infants, researchers at UT Southwestern Medical Center have found in an animal study.

12 Mar 2009

Estrogen may be a new postnatal therapy to improve lung function and other outcomes in preterm infants

"Ironically, a hormone that has received great attention as a potential means to optimize the health of older women may be a beneficial treatment for humans during the earliest stages of life," said Dr. Philip Shaul, professor of pediatrics at UT Southwestern and the study's senior author.

12 Mar 2009

Breath or urine analysis with optical gas sensors may detect cancer, diabetes

A future sensor may take away a patient's breath while simultaneously determining whether the patient has breast cancer, lung cancer, diabetes or asthma.

11 Mar 2009

Advances in stem cell research

Scientists at The University of Texas Health Science Center at Houston are on the forefront of stem cell research, developing novel therapies designed to generate heart cells, repair traumatic lung injuries, grow new bone and stanch the spread of cancer cells.

8 Mar 2009

Nitric Oxide News and Research

Scientists investigate health benefits of molecule associated with male sexual arousal

Novel light-sensitive compounds show promise for photodynamic cancer therapy

Being overweight or obese does not worsen asthma, but may reduce response to medications

Discovery of enzyme involved in inflammatory bowel disease

Clues about how blood forms could yield new strategies for treating blood diseases

New evidence of how high glucose damages blood vessels could lead to new diabetes treatments

Obstructive sleep apnea increases risk of heart and vascular disease

Nanoparticles applied to skin offer hope for erection problems

Alzheimer's disease linked to mitochondrial damage

Electroacupuncture protects acetylsalicylic acid-induced acute gastritis in rats

Aerovance starts phase IIb clinical trial with Aerovant for uncontrolled asthma

Missing enzyme GNSOR conveys major heart protection in pre-clinical work

Gilead commences phase II trial of Cicletanine for pulmonary arterial hypertension

Coenzyme rare to bacteria critical to Mycobacterium tuberculosis survival

Male diabetics found to have lower levels of hydrogen sulfide in their blood

Stem cell infusion and hyperbaric oxygen treatment improve islet function in diabetes

Estrogen activates critical lung genes to improve lung function following preterm birth

Estrogen may be a new postnatal therapy to improve lung function and other outcomes in preterm infants

Breath or urine analysis with optical gas sensors may detect cancer, diabetes

Advances in stem cell research

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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