Nitric Oxide News and Research

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Pulmonary hypertension in children may result from reduced activity of gene regulator

Too little activity by gene regulators called PPARs appears to be a major player in the irreversible lung damage that can occur in children with heart defects, researchers say.

5 Mar 2009

Research looks at protective effects of acupuncture against NSAID-induced ulceration in a rat model

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as anti-inflammatory and analgesic agents.

3 Mar 2009

Aerovance starts trial of Aerovant for uncontrolled asthma

Aerovance Inc. has announced that it has received clearance from the U.S. Food and Drug Administration (FDA) and the U.K. Medicines and Healthcare products Regulatory Agency (MHRA) to initiate Aerovance's Phase IIb clinical trial, AeroTrial(TM), of inhaled dry powder Aerovant in patients with uncontrolled asthma.

3 Mar 2009

Two compounds show great promise for cerebral palsy

Two compounds developed by Northwestern University chemists have been shown to be effective in pre-clinical trials in protecting against cerebral palsy, a condition caused by neurodegeneration that affects body movement and muscle coordination.

25 Feb 2009

Nitric oxide monitoring does not help most children with asthma

The level of nitric oxide (NO) in an asthmatic's exhaled breath can portend worsening asthma symptoms, and may even signify an imminent attack linked to underlying airway inflammation.

7 Jan 2009

Researchers develop natural, nontoxic method for biodegrading carbon nanotubes

University of Pittsburgh researchers have developed the first natural, nontoxic method for biodegrading carbon nanotubes, a finding that could help diminish the environmental and health concerns that mar the otherwise bright prospects of the super-strong materials commonly used in products, from electronics to plastics.

16 Dec 2008

Study to examine how breastfeeding impacts cost of healthcare for very low birth weight babies

The National Institutes of Health (NIH) has awarded nearly $3 million to support Rush University Medical Center's study analyzing how human breast milk impacts the health outcomes and health care cost savings for very low birth weight infants – babies less than 1500 grams.

16 Dec 2008

NicOx signs agreement with DSM for the commercial manufacture of naproxcinod drug substance

NicOx S.A. has announced it has signed an agreement with DSM for the commercial manufacture and supply of naproxcinod drug substance (or API, active pharmaceutical ingredient).

3 Dec 2008

More evidence on why the Mediterranean diet is good for heart

Researchers have discovered one potential mechanism by which briefly cutting off, then restoring, blood flow to arteries prior to a heart attack lessens the damage caused, according to a study published today in the journal Cardiovascular Research.

2 Dec 2008

Nitric oxide can change computational ability of the brain

Research from the Medical Research Council (MRC) Toxicology Unit at the University of Leicester shows that nitric oxide (NO) can change the computational ability of the brain.

26 Nov 2008

Light drinking has certain health benefits, researchers look at why

While the physiological damage and social havoc created by alcohol abuse and dependency are well-known, it is also true that light-to-moderate drinking has certain health benefits.

20 Nov 2008

Variations within three genes associated with lipid peroxidation could increase kidney cancer risk

A team of international scientists has identified three genes associated with the body's processing of fats that may increase susceptibility to kidney cancer.

17 Nov 2008

NicOx's Naproxcinod shows highly significant reduction in daytime blood pressure versus Naproxen

NicOx S.A. has announced that a new analysis of the data from the 104 Ambulatory Blood Pressure Monitoring (ABPM) study for naproxcinod was presented yesterday at the American Heart Association Scientific Sessions 2008, in New Orleans, USA.

12 Nov 2008

Scientists map steps to block enzyme phosphodiesterase 5's action in heart failure

Taking a cue from the way drugs like Viagra put the biological brakes on a key enzyme involved in heart failure, scientists at Johns Hopkins have mapped out a key chemical step involved in blocking the enzyme.

12 Nov 2008

Obesity raises levels of hormone leptin

Obese people who don't have high cholesterol or diabetes might think they're healthy - despite the extra pounds.

11 Nov 2008

Newly discovered protein may help explain tuberculosis' resiliency

Weill Cornell scientists have located a protein produced by the tuberculosis bacterium that may tell researchers more about how the invader lives so resiliently inside of the body.

6 Nov 2008

Parasites that live inside cells use loophole to thwart immune system

St. Jude Children's Research Hospital scientists have discovered a mechanism by which intracellular pathogens can shut down one of the body's key chemical weapons against them: nitric oxide.

4 Nov 2008

Parasites that live inside cells use loophole to thwart immune system

St. Jude Children's Research Hospital scientists have discovered a mechanism by which intracellular pathogens can shut down one of the body's key chemical weapons against them: nitric oxide. The researchers found that the microbes block nitric oxide production by subverting the biochemical machinery used by immune cells called macrophages to produce the chemical.

3 Nov 2008

Persistent bacterial infection exploits killing machinery of immune cells

A new study reveals an important and newly discovered pathway used by disease-causing bacteria to evade the host immune system and survive and grow within the very cells meant to destroy them. This discovery may lead to new treatments and vaccines for tuberculosis (TB) and certain other chronic bacterial and parasitic infections.

3 Nov 2008

Discovery of new pathway used by disease-causing bacteria to evade host immune system and survive

2 Nov 2008

Nitric Oxide News and Research

Pulmonary hypertension in children may result from reduced activity of gene regulator

Research looks at protective effects of acupuncture against NSAID-induced ulceration in a rat model

Aerovance starts trial of Aerovant for uncontrolled asthma

Two compounds show great promise for cerebral palsy

Nitric oxide monitoring does not help most children with asthma

Researchers develop natural, nontoxic method for biodegrading carbon nanotubes

Study to examine how breastfeeding impacts cost of healthcare for very low birth weight babies

NicOx signs agreement with DSM for the commercial manufacture of naproxcinod drug substance

More evidence on why the Mediterranean diet is good for heart

Nitric oxide can change computational ability of the brain

Light drinking has certain health benefits, researchers look at why

Variations within three genes associated with lipid peroxidation could increase kidney cancer risk

NicOx's Naproxcinod shows highly significant reduction in daytime blood pressure versus Naproxen

Scientists map steps to block enzyme phosphodiesterase 5's action in heart failure

Obesity raises levels of hormone leptin

Newly discovered protein may help explain tuberculosis' resiliency

Parasites that live inside cells use loophole to thwart immune system

Parasites that live inside cells use loophole to thwart immune system

Persistent bacterial infection exploits killing machinery of immune cells

Discovery of new pathway used by disease-causing bacteria to evade host immune system and survive

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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