Non Steroidal Anti Inflammatory Drug (NSAIDS) News and Research

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Use of the drug etodolac instead of drugs like Celebrex or Bextra could save $40 million annually

People in search of pain relief who take the generic anti-inflammatory etodolac suffer 60 percent fewer gastrointestinal complications than those who take similar drugs, according to researchers at UT Southwestern Medical Center at Dallas and the Dallas Veterans Affairs Medical Center.

14 Nov 2004

Cyclooxygenase (COX) inhibitors tested in both prevention and treatment clinical trials

Numerous compounds are examined by the National Cancer Institute (NCI) for their potential to prevent or treat cancer. One class of compounds, cyclooxygenase (COX) inhibitors, is currently being tested in both prevention and treatment clinical trials.

4 Nov 2004

Allopurinol, a common gout drug may also offer some protection against colorectal cancer

A commonly prescribed drug used to treat gout may also offer some protection against colorectal cancer, according to a new study from researchers at the University of Michigan and in Israel.

25 Oct 2004

COX-2 agents have influenced the way physicians prescribe rheumatology medication

COX-2 agents, with their perceived reduction in side effects, have contributed substantially to a dramatic increase in NSAIDs (non-steroidal anti-inflammatory drugs) prescription utilization and influenced the way physicians prescribe rheumatology medication

18 Oct 2004

Topical nonsteroidal anti-inflammatory drug eases symptoms of osteoarthritis of the knee

Symptoms of primary osteoarthritis of the knee, including pain and stiffness, were significantly improved in patients who used a topical nonsteroidal anti-inflammatory drug (NSAID), according to an article in the October 11 issue of The Archives of Internal Medicine.

11 Oct 2004

Canadian Rheumatology Association issues statement on Vioxx alternatives

The Canadian Rheumatology Association (CRA) has issued a statement to its 350 members and other interested parties, recommending alternative treatment considerations in the wake of the worldwide recall of Merck's rofecoxib, (Vioxx(R)) last week.

7 Oct 2004

U.S. healthcare industry reaction to the withdrawal of Vioxx from the world-wide market

NDCHealth has announced U.S. healthcare industry reaction to the Sept. 30 announcement by Merck & Co. that it was withdrawing its anti-arthritic medication Vioxx from the world-wide market.

5 Oct 2004

Data demonstrate that Celebrex does not increase the risk of heart attack or stroke in patients with arthritis and pain

Pfizer has said that three large long-term Celebrex (celecoxib capsules) studies involving more than 6,000 patients have not shown any significant safety issues and are expected to continue to completion.

4 Oct 2004

HER-2 cell surface receptors tun on genes associated with carcinogenesis

Researchers at The University of Texas M. D. Anderson Cancer Center now have evidence that receptors found on tumors that were believed to function only on the surface of cells can actually switch on genes inside a cell's nucleus, thus promoting cancer development in two distinct ways.

21 Sep 2004

HHS enhances Medicare drug card program to help seniors

Health and Human Services Secretary Tommy G. Thompson today announced new measures to help seniors get the lowest price possible for their medicines by allowing them -- for the first time -- to compare prices for similar drugs used to treat common diseases such as high cholesterol or blood pressure.

15 Sep 2004

Potential new drug for the treatment of sickle cell disease

The results were published in the June 2004 issue of The British Journal of Haematology (BJH). MX-1520 is a prodrug of vanillin, a very popular food additive generally regarded as safe (GRAS) by the FDA.

13 Sep 2004

Stress won't cause stomach ulcers, but it can make them worse

“Stress won't cause stomach ulcers, but it can make them worse,” says Dr. David Graham, professor of medicine and molecular virology and microbiology at Baylor College of Medicine. “Stress causes the body to produce higher amounts of acid, which can irritate preexisting ulcers.”

27 Aug 2004

COX2 inhibitor lumiracoxib could be an effective treatment for osteoarthritis

The use of non-selective non-steroidal anti-inflammatory drugs (NSAIDs) is widespread to reduce the pain associated with osteoarthritis; however the sideeffects of these drugs can be severe, sometimes leading to gastro-intestinal ulcer complications which account for around 7000 US and 1000 UK deaths each year.

21 Aug 2004

First evidence of the molecular link between inflammation and cancer

The investigators found that a gene called I-kappa-B kinase (IKK beta), a pro-inflammatory gene, acts differently in two cell types to cause cancer. When IKK beta was deleted, the cancer incidence and tumor growth in mice was decreased by nearly 80 percent.

5 Aug 2004

New guidelines for water, salt and potassium intake of Americans

Nutrition experts from the Institute of Medicine of the National Academies have released new guidelines for water, salt and potassium intake of Americans.

5 Aug 2004

Using topical non-steroidal anti-inflammatory drugs to relieve the pain of osteoarthritis is only beneficial for the first two weeks

Using topical non-steroidal anti-inflammatory drugs (NSAIDS) to relieve the pain of osteoarthritis is only beneficial for the first two weeks, finds a study available on bmj.com today.

29 Jul 2004

Evidence that new anti-inflammatory drug may sensitize leukemia, and breast and lung cancers to conventional chemotherapy

Ohio researchers have used a recently developed anti-inflammatory drug as a starting point to construct a possible new, targeted anti-cancer agent.

10 Jul 2004

Knee osteoarthritis (OA) is a leading cause of disability in the elderly

Knee osteoarthritis (OA) is a leading cause of disability in the elderly, according to information in the article. Treatment for knee OA, which includes surgery, weight loss, muscle-strengthening exercise, and joint protection techniques, is aimed at improving or maintaining knee function, and targeting symptoms.

29 Jun 2004

Prescription pain medications may slow healing process in shoulder operations

A study of small laboratory animals suggests that prescription pain medications may delay healing in rotator cuff repair, a common shoulder operation, according to a new study by a team of doctors at the Hospital for Special Surgery.

26 Jun 2004

Serious deficiencies in the healthcare provision for people with arthritis / rheumatism

More than 100 million people in Europe are affected by arthritis / rheumatism, making it Europe’s most widespread chronic disease. The condition can have serious consequences, ranging from severe pain to loss of mobility, and delays in diagnosis and treatment have been shown to increase the risk of further joint damage.

15 Jun 2004