Nucleotides News and Research

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Detailed portrait of 700 proteins that help maintain DNA integrity

Cells have the remarkable ability to keep track of their genetic contents and -- when things go wrong, to step in and repair the damage before cancer or another life-threatening condition develops.

28 May 2007

Groundbreaking research on type 1 congenital myotonic dystrophy

Each year, the parents of an estimated one in 20,000 newborns are shocked to learn their child has type 1 congenital myotonic dystrophy (CDM1), a progressive and crippling genetic disorder.

24 May 2007

Scientists discover molecular mechanism that keeps HSV-1 activation restricted to a single gene for months or even years

By adulthood, most people have suffered at least one bout of painful cold sores brought on by the Herpes simplex virus 1, also known as HSV-1.

4 May 2007

Unicellular microRNA discovery

In the May 15th issue of Genes & Development, an international collaboration of researchers, led by Dr. Yijun Qi (National Institute of Biological Sciences, China), report on their discovery of microRNAs in the unicellular green alga, Chlamydomonas reinhardtii.

30 Apr 2007

Researchers find clear genetic risk factors for type 2 diabetes

Scientists from the Broad Institute of Harvard and MIT, Lund University and Novartis have announced the discovery of three unsuspected regions of human DNA that contain clear genetic risk factors for type 2 diabetes, and another that is associated with elevated blood triglycerides.

27 Apr 2007

microRNAs can function as tumor suppressors

University of Virginia researchers have discovered that microRNAs, a form of genetic material, can function as tumor suppressors in laboratory studies.

26 Apr 2007

New biotech company develops UD-patented technologies for repairing genes

OrphageniX Inc., a new biotechnology company founded by University of Delaware researchers, has been established in Wilmington to develop and commercialize UD-patented technologies for repairing genes that cause rare, hereditary diseases such as sickle cell anemia and spinal muscular atrophy.

25 Apr 2007

Discovery of important clue to the susceptibility of individuals to Crohn's disease

Crohn's disease is a chronic relapsing inflammatory disorder of the intestinal tract that affects an estimated 0.15% of people in the developed world. Common symptoms include abdominal pain and diarrhea, but the disorder is often associated with debilitating clinical complications.

21 Apr 2007

Discovery of molecular mechanism that alters strength of higher brain network connections

Yale School of Medicine and University of Crete School of Medicine researchers report in Cell April 20 the first evidence of a molecular mechanism that dynamically alters the strength of higher brain network connections.

21 Apr 2007

Avalon Pharmaceuticals announces results of AVN944 biomarker study

Avalon Pharmaceuticals has announced the results of an AVN944 biomarker study that utilized Avalon's proprietary AvalonRx technology to identify gene signatures that may be useful for patient stratification.

18 Apr 2007

New genetic risk factors for Crohn's disease

An international research team , including investigators from Massachusetts General Hospital (MGH) and the Broad Institute of Harvard University and Massachusetts Institute of Technology, has identified several novel genetic variations associated with the risk of Crohn's disease.

16 Apr 2007

Health disparities in access to healthcare

Minority individuals are much more likely to develop and die from cancer than the general U.S. population.

16 Apr 2007

Analysis of Rhesus monkey genome provides new clues to primate biology

An international consortium of researchers has published the genome sequence of the rhesus macaque monkey and aligned it with the chimpanzee and human genomes.

12 Apr 2007

Calories from fat, carbohydrate, and protein may interact with genes

We observed an interaction between APOA5 and dietary fat intake, but we did not see an interaction between APOA5 and carbohydrate or protein intake for any genetic variants of APOA5,” says Ordovas, who is corresponding author of the study.

10 Apr 2007

Protein alpha synuclein plays important role in regulation of dopamine function

SNCA mutations can lead to significant problems, such as the neurodegenerative disorder Parkinson's disease, which is caused by a substantially reduced production of dopamine.

3 Apr 2007

Critical genetic factor identified in the control of heart form and function

Researchers at the Gladstone Institute of Cardiovascular Disease (GICD) announced they have identified a critical genetic factor in the control of many aspects of heart form and function.

2 Apr 2007

Multiple genetic risk factors for prostate cancer found

A study led by researchers at the Keck School of Medicine of the University of Southern California (USC) and Harvard Medical School has identified seven genetic risk factors DNA sequences carried by some people but not others that predict risk for prostate cancer.

2 Apr 2007