Nucleotides News and Research

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New high-resolution data on intact ribosome

A new, sharper picture of the nano-machine that translates our genetic program into proteins promises to help researchers explain how some types of antibiotics work and could lead to the design of better ones.

7 Nov 2005

Analytical method to trace the lineage trees of cells

Some fundamental outstanding questions in science - "Where do stem cells originate?" "How does cancer develop?" "When do cell types split off from each other in the embryo?" - might be answered if scientists had a way to map the history of the body's cells going back to the fertilized egg.

30 Oct 2005

Gene involved in B-cell development might play a role in multiple sclerosis

The results of a large study published today in the open access journal BMC Neurology reveal that multiple sclerosis (MS) patients are more likely to carry two specific genetic variations in the Early B-cell factor gene (EBF-1), than healthy individuals.

30 Oct 2005

HapMap will give clues to many common diseases

Researchers say that they have completed a map that charts patterns of human genetic variation in the world population, to better understand human biology, evolution and how to diagnose diseases.

27 Oct 2005

New insights into how genetic mutations arise

Researchers at Stanford University have created a larger-than-normal DNA molecule that is copied almost as efficiently as natural DNA.

27 Oct 2005

Study provides insight into cellular defenses against genetic mutation

With their latest discovery, researchers have significantly advanced the understanding of how human cells protect themselves from constant and potentially destructive changes in gene expression.

25 Oct 2005

Newly discovered role of MECP2 gene in Rett Syndrome

Huda Zoghbi, of Baylor College of Medicine and the Howard Hughes Medical Institute and Juan Young, also of Baylor and colleagues report in the online Early Edition of the Proceedings of the National Academy of Science, posted the week of October 17, 2005, that the Rett Syndrome gene, MECP2, regulates RNA splicing.

18 Oct 2005

Hormone responsible for types of high blood pressure could also cause preeclampsia

Researchers at the University of Cincinnati (UC) Academic Health Center have found evidence of a hormone they say is responsible for certain types of high blood pressure (hypertension), and could also cause preeclampsia, a potentially dangerous condition that occurs during pregnancy.

17 Oct 2005

Protein called CPSF73 performs a necessary step in the production of human chromosomes

The study found that a protein called CPSF73 acts like scissors to cut strands of histone messenger RNA (mRNA) in the cell nucleus. This cutting action produces the mRNA needed to create histone proteins that combine with DNA to form chromosomes.

12 Oct 2005

Most comprehensive picture to date of how influenza viruses evolve and are transmitted

In the first large-scale effort of its kind, researchers have determined the full genetic sequence of more than 200 distinct strains of human influenza virus.

5 Oct 2005

Research on cartilage erosion and bone abnormalities

While characteristic of osteoarthritis (OA), a degenerative joint disease that affects some 20 million Americans, cartilage erosion and bone abnormalities are also associated with many rare hereditary conditions.

3 Oct 2005

Possibility of tailored treatments for addiction based on how a person's genes behave

Scientists have learned how a genetic variation long suspected in making some people susceptible to alcoholism and narcotic drug addiction actually does so.

27 Sep 2005

First large-scale whole genome map of genetic variability associated with Parkinson's disease

Mayo Clinic researchers in collaboration with scientists at Perlegen Sciences, Inc. and funded by the Michael J. Fox Foundation for Parkinson's Research have produced the first large-scale whole genome map of genetic variability associated with Parkinson's disease.

19 Sep 2005

Significant advance in the study of small ribonucleic acids

Scientists from the University of Delaware have made a significant advance in the study of small ribonucleic acids (RNAs), discovering 10 times more small RNAs in the plant Arabidopsis than previously had been identified. The advance is reported in the Sept. 2 issue of Science magazine.

5 Sep 2005

Rett Syndrome gene discovery

Adrian Bird of the University of Edinburgh and colleagues report in the online issue of Molecular Cell that the "Rett Syndrome protein", MeCP2, only binds to genes with a specific sequence of nucleotide bases. This knowledge will aid in the identification of the genes that are regulated by the gene MECP2

4 Sep 2005