Oncogene News and Research

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An oncogene is a gene that, when mutated or expressed at high levels, helps turn a normal cell into a tumor cell.

Johns Hopkins scientists design new cell model of aging-associated colon cancer risk

Johns Hopkins Kimmel Cancer Center researchers say a new study of clusters of mouse cells known as "organoids" has significantly strengthened evidence that epigenetic changes, common to aging, play a essential role in colon cancer initiation.

12 Apr 2019

Researchers develop statistical approach to reveal elusive cancer-promoting genes

Australian and US researchers have developed a way to discover elusive cancer-promoting genes, and have already identified one that appears to promote aggressive breast cancers.

11 Mar 2019

New clinical genomic testing helps identify mutations that drive childhood melanoma

Comprehensive clinical genomic testing of an adolescent patient, including whole genome sequencing, helped researchers identify mutations in a single gene that drive the most common childhood melanoma.

5 Mar 2019

Estrogen can affect surrounding brain cells to promote triple-negative breast cancer metastasis

Triple-negative breast cancers are more likely than other breast cancer types to metastasize and are especially likely to go the brain in younger women. Researchers have tested various hypotheses to explain this danger.

2 Mar 2019

Key to treat deadly cancers could lie deep within complex machinery of human cell

Buried deep within the dazzlingly intricate machinery of the human cell could lie a key to treating a range of deadly cancers, according to a team of scientists at Florida State University.

27 Feb 2019

New research uncovers crucial link between polyamines and MYCN

The MYCN oncogene has long been known to be a key cause of a number of deadly solid tumor cancers, including neuroblastoma, which claims more lives of children under the age of 5 than any other cancer.

4 Feb 2019

Study sheds light on the genetic causes of tumors in salivary glands

Acinic cell carcinoma is the third most common malignant form of salivary gland cancer. These tumors are similar to normal salivary gland tissue and occur most frequently in the parotid gland.

31 Jan 2019

Researchers discover immune regulator that appears to dictate glioblastoma

Researchers at The University of Texas MD Anderson Cancer Center have discovered an immune regulator that appears to dictate glioblastoma progression by shutting down immune surveillance, indicating a potential new area of therapeutic investigation.

28 Jan 2019

Regular use of common pain relief medicines improves survival for head and neck cancer patients

Regular use of a common type of medication, such as aspirin and ibuprofen, significantly improves survival for a third or more patients with head and neck cancer, a new study led by UC San Francisco has found.

25 Jan 2019

Identifying genetic factors that lead to squamous cell carcinoma

Skin cancer is on the rise in the United States. Squamous cell carcinoma, the second most common form of cancer in the U.S., has the highest mortality rate of all non-melanoma skin cancers. In roughly two to five percent of patients, the disease will metastasize and spread throughout the body, making it difficult to treat.

14 Jan 2019

New computer model predicts prostate cancer progression

An international team of cancer researchers from Denmark and Germany have used cancer patient data to develop a computer model that can predict the course of disease for prostate cancer.

11 Dec 2018

Scientists find answers to how cancer spreads

How does cancer spread? While studying human brain tumor cells, a team of scientists at the Research Institute of the McGill University Health Centre found some answers to this crucial, yet so far unanswered question.

10 Dec 2018

Growth and spread of deadly eye tumor suppressed in cells, animals

By comparing genetic sequences in the eye tumors of children whose cancers spread with tumors that didn't spread, Johns Hopkins Medicine researchers report new evidence that a domino effect in cells is responsible for the cancer spreading.

12 Nov 2018

Failed DNA repair triggers chromosomal chaos in cancer cells

Researchers have established the trigger for catastrophic events that occur within the chromosomes of cancer cells and lead to cancer cell death.

12 Nov 2018

CNIO researchers link MASTL protein to origin of thrombocytopenia

The Cell Division and Cancer Group of the Spanish National Cancer Research Centre has discovered that MASTL, the protein whose function in the organism has not yet been sufficiently investigated, plays an important role in controlling the cytoskeleton, the structure that gives shape to the cells, and enables their mobility and capacity for grouping.

1 Nov 2018

Insights into tumor initiation pave way for new skin cancer treatments

Researchers from VIB and KU Leuven uncovered a key vulnerability of melanoma. While studying the role of the melanoma-specific long non-coding RNA SAMMSON in tumor initiation, the researchers found that it boosts protein synthesis in different cellular compartments. Normal cells are alerted by modification in protein synthesis and react to this threat, but only if this process is altered in one compartment at the time.

29 Oct 2018

Aggressive breast cancer hijacks normal protective physiological process to survive

A member of a protein family known for protecting our cells also protects cancer cells in aggressive, metastatic breast cancer, scientists report.

3 Oct 2018

Aggressive breast cancer cells hijack protective protein to aid growth

A new study has revealed that a protein known to protect healthy cells also protects cancer cells in aggressive breast cancer.

2 Oct 2018

Drosophila study shows chromosomal instability promotes invasive behavior in human tumors

Metastatic tumors are characterized by a high degree of chromosomal instability--that is to say a constant change in the number and structure of chromosomes they hold. In spite of this observation, it is unknown whether chromosomal instability contributes to the metastatic process.

26 Sep 2018

Researchers discover novel targeting agents to prevent cancer metastasis

Recently, a research team led by Maurizio Pellecchia at the University of California, Riverside, discovered a way for chemotherapy drug paclitaxel to target migrating, or circulating, cancer cells, which are responsible for the development of tumor metastases.