Optogenetics News and Research

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Cortex plays a key role in fear learning

The study, initiated by the Swiss researchers and published in Nature, constitutes ground-breaking work in exploring emotions in the brain.

12 Dec 2011

Scientists seek to prove beta oscillations of the cortex

Before she could seek to convince the world that her computer model of a key brain circuit explains a fundamental, 80-year-old mystery of neuroscience with potential relevance to Parkinson's disease, Stephanie Jones sought to convince Christopher Moore.

29 Nov 2011

New collaboration reinforces Sanofi's translational discovery platform for retinal diseases

The Max Planck Society (Max-Planck-Gesellschaft), Germany's leading basic research organization, announced today that it has signed with Fovea Pharmaceuticals, the Ophthalmology Division of Sanofi, a research collaboration and license agreement to identify and develop innovative solutions for restoring vision in patients suffering from diseases affecting the retina.

16 Sep 2011

Scientists identify brain-circuit defect that triggers absence seizures

Researchers at the Stanford University School of Medicine have identified a brain-circuit defect that triggers absence seizures, the most common form of childhood epilepsy.

23 Aug 2011

Researchers demonstrate a way to control excitation and contraction in cardiac muscle cells

By employing optogenetics, a new field that uses genetically altered cells to respond to light, and a tandem unit cell (TCU) strategy, researchers at Stony Brook University have demonstrated a way to control cell excitation and contraction in cardiac muscle cells, the details of which are published in the early online edition of Circulation: Arrhythmia & Electrophysiology: "Stimulating Cardiac Muscle by Light: Cardiac Optogenetics by Cell Delivery."

19 Aug 2011

Researchers influence activity of nerve cells with laser light

Unlike conventional methods, with the so-called optogenetics, the researchers are able to target one cell type. "We are now going to use this method to find out exactly what goes wrong in the nerve cells in movement disorders such as ataxias", said Prof. Dr. Stefan Herlitze.

21 Jul 2011

UNC study uses optogenetics to tweak brain wiring responsible for drug addiction behaviors

Using a combination of genetic engineering and laser technology, researchers at the University of North Carolina at Chapel Hill have manipulated brain wiring responsible for reward-seeking behaviors, such as drug addiction.

30 Jun 2011

Invention of optogenetics sheds light on how brain works

Commenting on Edward Boyden's article, Ben Barres, Head of the Neuronal & Glial Cell Biology Section of Faculty of 1000 and Professor at Stanford University School of Medicine said: "There will probably be a Nobel prize for optogenetics someday as it has revolutionized our attempts to understand how the brain works. This article provides a fascinating insight into the birth of optogenetics and the roles of the major players."

4 May 2011

Stanford professor receives AFER Ludwig von Sallman Clinician-scientist Award

Karl Deisseroth, MD, PhD, has been named the first recipient of the Ludwig von Sallman Clinician-scientist Award, presented by the ARVO Foundation for Eye Research to a clinician-scientist under age 40.

30 Mar 2011

New study sheds 'light' on intricate brain cell connections responsible for anxiety

A new study sheds light--both literally and figuratively--on the intricate brain cell connections responsible for anxiety.

10 Mar 2011

Scientists suggest that lateral habenula can be a prime locus of human depression

A team of neuroscientists at Cold Spring Harbor Laboratory, Brookhaven National Laboratory and UC San Diego has collected evidence suggesting that a previously overlooked portion of the brain could be a prime locus of human depression.

24 Feb 2011

Guide star and time-reversal mirror in biomedical imaging

Astronomers have a neat trick they sometimes use to compensate for the turbulence of the atmosphere that blurs images made by ground-based telescopes. They create an artificial star called a guide star and use its twinkling to compensate for the atmospheric turbulence.

11 Feb 2011

Video game-based technologies allow new insight into memory, perception and motor control

New tools inspired by video games are revealing how the brain senses and responds to its surroundings, finds new human and animal research. Taking advantage of state-of-the art technologies to track and mimic real-life environments, these studies show with new detail how the brain navigates, identifies, and remembers a setting. In additional human research, scientists apply these same technological advances to help people who have experienced strokes regain skills.

17 Nov 2010

Stanford University scientist receives HFSP Nakasone Award for neuronal network study

The first HFSP Nakasone Award has been conferred upon Karl Deisseroth of Stanford University for his pioneering work on the development of optogenetic methods for studying the function of neuronal networks underlying behavior.

12 Nov 2010

Researchers discover how cocaine corrupts brains' reward center

Mount Sinai researchers have discovered how cocaine corrupts the brain and becomes addictive. These findings-the first to connect activation of specific neurons to alterations in cocaine reward-were published in Science on October 15. The results may help researchers in developing new ways of treating those addicted to the drug.

19 Oct 2010

New tool could help researchers understand the neural basis of olfaction

Harvard University neurobiologists have created mice that can "smell" light, providing a potent new tool that could help researchers better understand the neural basis of olfaction.

18 Oct 2010

Optogenetics helps to restore optimal movement in people with physical disabilities

Researchers at Stanford University were able to use light to induce normal patterns of muscle contraction, in a study involving bioengineered mice whose nerve-cell surfaces are coated with special light-sensitive proteins.

28 Sep 2010

Brain stimulation with ultrasound may enhance cognitive function

The ability to diagnose and treat brain dysfunction without surgery, may rely on a new method of noninvasive brain stimulation using pulsed ultrasound developed by a team of scientists led by William "Jamie" Tyler, a neuroscientist at Arizona State University. The approach, published in the journal Neuron on June 9, shows that pulsed ultrasound not only stimulates action potentials in intact motor cortex in mice but it also "elicits motor responses comparable to those only previously achieved with implanted electrodes and related techniques," says Yusuf Tufail, the lead author from ASU's School of Life Sciences.

10 Jun 2010

Blood-flow fMRI to be used to study brain-wide impact of neural circuitry changes

Like a motorist who knows that the "check engine" light indicates something important but ill-defined is happening, neuroscientists have relied heavily on an incompletely understood technology called functional magnetic resonance imaging to show them what the brain is doing when people respond to different stimuli.

17 May 2010

Researchers use new tools to study how brain responds when injury occurs

Researchers at four institutions, led by Stanford University and Brown University, have begun an effort with more than $14 million of federal funding to learn both how the brain and its microcircuitry react to sudden physiological changes and what can be done to encourage recovery from injury.

6 May 2010