Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

Study finds Omicron infection effectively induces immunity against itself and enhances protection against other variants in vaccinated individuals

Researchers investigated the effectiveness of the SARS-CoV-2 Omicron-variant induced immunity, whether it is cross-protective against other variants, and if earlier infection with the SARS-CoV-2 Delta variant offers protection against Omicron.

20 Jan 2022

Direct effect of SARS-CoV-2 on the kidney

Researchers infected human-induced pluripotent-stem-cell (iPSC)-derived kidney organoids with SARS-CoV-2 to study the virus's direct effect on the kidney.

18 Jan 2022

Exploring the relationship between stem cells and COVID-19

Though COVID-19-related stem cell clinical research is still in its infancy, stem cell treatment offers extensive clinical application possibilities and a far-reaching relevance thanks to ongoing exploration of stem cell clinical research and data mining.

14 Jan 2022

Using lab-grown stomachs to shed light on the symptoms of COVID-19

Could lab-grown 'mini-stomachs' be used to look at COVID-19 symptoms in children? In this interview, we speak to Paolo De Coppi to find out more.

13 Jan 2022

Study opens up prospects for using virotherapy to treat central nervous system tumors

In a study conducted at the University of São Paulo's Human Genome and Stem Cell Research Center (HUG-CELL) in Brazil, serial systemic injections of zika virus into mice with brain tumors destroyed the cancer without causing neurological damage or injuring other organs, and increased the animals' survival rate.

11 Jan 2022

Engineered small extracellular vesicles for the neutralization of SARS-CoV-2

Characterizing these engineered sEVs, the researchers demonstrated that the soluble angiotensin-converting enzyme 2 (sACE-2) loaded sEV successfully binds and thus inhibits the entry of wild-type SARS-CoV-2 as well as its variants, protecting against SARS-CoV-2 infection. They also demonstrated the therapeutic efficacy of these engineered sEVs in vivo.

9 Jan 2022

Microgravity likely to contribute to life-saving stem cell advances on Earth

The secret to producing large batches of stem cells more efficiently may lie in the near-zero gravity conditions of space. Scientists at Cedars-Sinai have found that microgravity has the potential to contribute to life-saving advances on Earth by facilitating the rapid mass production of stem cells.

30 Dec 2021

Intestinal organoids used to explain why bats infected with viruses do not succumb to diseases

Experiments attempting to explain why bats can be infected with many viruses at a time without succumbing to diseases such as COVID-19-;knowledge that could help us to reduce the threat to humans of infectious disease-;have struggled until now with the fact that live wild bats make poor research subjects.

30 Dec 2021

Human iPSC-derived fallopian tube organoids reveal the origins of common ovarian cancer

Stem cell scientists have revealed the origins of a common ovarian cancer by modeling fallopian tube tissues, allowing them to characterize how a genetic mutation puts women at high risk for this cancer.

29 Dec 2021

Study suggests spike mutation makes SARS-CoV-2 Omicron milder

The Omicron spike is relatively poorly cleaved and impaired in mediating cell-cell fusion and syncytia formation, contrary to predictions.

28 Dec 2021

SARS-CoV-2-induced kidney damage

Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infects the kidneys and contributes to tissue scarring, as shown by researchers from the RWTH Uniklinik Aachen, Germany, and Radboudumc, The Netherlands. The developed scar tissue in the infected kidneys may suggest a possible impact on kidney outcomes in the long term.

27 Dec 2021

New Omicron variant may be better at evading vaccine-induced antibodies, research shows

The Omicron variant of SARS-CoV-2 may be significantly better than previous variants at evading vaccine-induced antibodies, according to new research from Cambridge - but preliminary evidence suggests it is less likely to cause severe COVID-19 illness in the lungs.

20 Dec 2021

Salk researchers win $250,000 award to study cellular, molecular drivers of pancreatic cancer

Professor Ronald Evans and Assistant Professor Dannielle Engle have been granted a 2021 ASPIRE (Accelerating Scientific Platforms and Innovative Research) award to study the cellular and molecular drivers of pancreatic cancer, one of the deadliest cancers with few effective treatment options.

18 Dec 2021

Major international research center may drive the development of future stem cell-based treatments

A grant from the Novo Nordisk Foundation of up to 300 million euro now enables the establishment of a major international research center focused on stem cell medicine.

17 Dec 2021

Cedars-Sinai researchers discover growth hormone in the colon that influences aging process

Investigators at Cedars-Sinai have identified growth hormone in the colon that increases as the colon ages—a discovery that can help guide the development of a new anti-aging therapy.

16 Dec 2021

Ophthalmology professor receives $75,000 grant to support international collaborations on eye research

Steven DeVries, MD, PhD, the David Shoch, MD, PhD, professor of Ophthalmology, has received an International Research Collaborators Award from Research to Prevent Blindness.

14 Dec 2021

Screening FDA-approved compounds shown to possess antiviral or antimicrobial activity for SARS-CoV-2 inhibition

Researchers have screened several compounds that could show the ability to inhibit SARS-CoV-2.

10 Dec 2021

The antiviral potential of 4′-fluorouridine as an oral treatment against RSV and SARS-CoV-2

New research reports 4’-Fluorouridine (4′-FlU) as an oral antiviral against RSV and SARS-CoV-2.

7 Dec 2021

Mini-stomach organoids could be used to study how SARS-CoV-2 infection affects children

The team, led from Great Ormond Street Hospital (GOSH), UCL Great Ormond Street Institute of Child Health (UCL GOS ICH) and the Istituto Zooprofilattico Sperimentale delle Venezie (Legnaro, Italy), have built on recent advances to grow 'mini-organs' in a laboratory, known as organoids.

2 Dec 2021

SARS-CoV-2 can directly invade human kidney cells, research shows

Up to 25% of patients' COVID-19 cases involve acute kidney injury—the kidneys' equivalent of a heart attack.

29 Nov 2021