Pathophysiology News and Research

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Review: Pathophysiology, diagnosis and management of carcinoid heart disease

Announcing a new article publication for Cardiovascular Innovations and Applications journal.

15 Jun 2023

Connecting the inflammatory dots: Obesity, depression, and Alzheimer's linked by neuroinflammation

Obesity-induced neuroinflammation significantly contributes to the pathophysiology of depression and Alzheimer's disease. Targeting midlife stage for intervention is crucial to potentially prevent Alzheimer's pathology.

13 Jun 2023

Spinal neural circuit dysfunction mediates movement symptoms in dystonia

Many neurological conditions that involve involuntary muscle contractions have long been considered as diseases of the brain.

6 Jun 2023

Research sheds new light on the genetic architecture of bipolar disorder

Bipolar disorder (BD) is a major psychiatric condition that afflicts about 1% of people. Symptoms of BD include sudden onset of depressive mood with loss of interest which alternates with a manic state of hyperactivity.

5 Jun 2023

Can adherence to the Mediterranean diet reduce gestational stress and anxiety in pregnant women?

Researchers investigated the influence of structured Mediterranean diet intervention on the anxiety and stress levels.

1 Jun 2023

DIALIVE device may be a disease-modifying therapy for patients with acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) occurs in 30% of hospitalized cirrhosis patients, leading to over one million deaths worldwide each year.

31 May 2023

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

To commemorate World Multiple Sclerosis (MS) Day, we speak to Dr. Cameron McAlpine about his latest research that sought to understand better the proteins and signals that act as messengers between brain and immune cells in MS.

30 May 2023

Unlocking the brain-lung dialogue key to future treatments for critical care patients

Researchers review evidence on the crosstalk between the lung and brain and identified potential areas for further research.

29 May 2023

Insights into the direction and extent of gut microbiome dysbiosis in Alzheimer’s disease and mild cognitive impairment

Researchers performed a meta-analysis to determine the association between intestinal microbiota and Alzheimer’s disease (AD).

26 May 2023

Researchers discover sex-specific genes, molecular pathways that contribute to Alzheimer's disease progression

Alzheimer's Disease (AD) is a complex neurodegenerative illness with genetic and environmental origins.

19 May 2023

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

Researchers derived peptides from the SARS-CoV-2 spike protein to assess COVID-19-associated inflammatory changes using zebrafish models.

19 May 2023

Researchers find that SARS-CoV-2 directly infects hepatocytes that cause hyperglycemia

Researchers investigate whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused hyperglycemia.

18 May 2023

Clinical trial shows efficacy and safety of brepocitinib for treating adults with psoriatic arthritis

Brepocitinib is an oral drug that inhibits certain enzymes involved in inflammation-;called tyrosine kinase 2 and Janus kinase 1-;and is being tested for the treatment of several immunological diseases.

17 May 2023

New insight into mechanisms underlying hippocampal atrophy in individuals at risk for psychosis

Dysregulation of the dopamine neurotransmitter system has long been associated with schizophrenia and other forms of psychosis, but recently researchers have begun to examine the glutamate and GABA systems as well.

12 May 2023

Environmental PAH exposure associated with increased rheumatoid arthritis risk

The amount of environmental exposure to polycyclic aromatic hydrocarbons, or PAH for short, is strongly linked to a person's risk of developing rheumatoid arthritis, suggests research published in the open access journal BMJ Open.

10 May 2023

Boosting gut health with short-chain fatty acids

Research paper provides an overview of short-chain fatty acids (SCFAs) and their role in regulating gut homeostasis. It also discusses SCFA-producing bacteria and potential therapeutic approaches to boost SCFA levels in the gut to treat related diseases.

9 May 2023

Understanding Lupus: an interview with the Garvan Institute

To commemorate World Lupus Day, we spoke to Elissa Deenick, co-lead of the Precision Immunology Program at the Garvan Institute, about the current state of lupus understanding and what needs to happen to make lupus visible.

9 May 2023

Mount Sinai researchers identify a new therapeutic target for MS and other brain disorders

Cross-talk between brain cells and peripheral immune cells can modulate the progression of multiple sclerosis (MS), Mount Sinai researchers have discovered.

8 May 2023

Neuropathic pain study uncovers pathophysiological mechanism and promising therapeutic target

Neuropathic pain -; abnormal hypersensitivity to stimuli -; is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3 percent to 17 percent of adults suffer from neuropathic pain, including a quarter of people with diabetes and a third of people with HIV.

5 May 2023

Team successfully treats aggressive vascular malformation in an infant's brain before birth

In a first, a team from Brigham and Women's Hospital and Boston Children's Hospital successfully treated an aggressive vascular malformation in an infant's brain before birth, avoiding potentially fatal symptoms after delivery.