Pathophysiology News and Research

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What are the major findings of long COVID research?

Researchers explored existing literature on long coronavirus disease (COVID). They highlighted key immunological findings, similarities with other diseases, symptoms, and associated pathophysiological mechanisms, and diagnostic and therapeutic options, including COVID-19 vaccinations.

17 Jan 2023

Acquired mutations in 'Guardian of the Genome' accelerate the development of atherosclerosis

A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), working in collaboration with institutes in the USA, has demonstrated that acquired mutations in the gene encoding the protein p53 contribute to the development of atherosclerotic cardiovascular disease.

16 Jan 2023

Protein heat shock transcription factor 1 may be a viable therapeutic target for hepatoblastoma

Although rare compared to adult liver cancers, hepatoblastoma is the most common pediatric liver malignancy, and its incidence is increasing.

16 Jan 2023

New blood test tracks neurodegenerative changes specifically in Alzheimer's disease

A new blood test that can track and follow the neurodegeneration in Alzheimer's disease - and exclude other dementias.

16 Jan 2023

The impact of early life microbial colonization and respiratory diseases on the respiratory microbiome

Researchers reviewed the impact of the interactions between the respiratory microbiota and the immune system.

13 Jan 2023

IBS-related changes revealed using real time recording with a wearable device

Irritable bowel syndrome (IBS) is a difficult disease to treat, characterized by chronic abdominal pain related to bowel movements, of which there are four types: diarrheal, constipation, mixed, and unclassifiable.

12 Jan 2023

2022: a year in MIS-C research

In a recent review published in Nature Reviews Rheumatology, researchers reviewed existing data on the multisystem inflammatory syndrome in children (or MIS-C).

11 Jan 2023

Study suggests many symptoms are more common after COVID-19 infection, but only a few are commonly associated with a long COVID diagnosis

Researchers compared symptoms in patients with and without prior COVID-19 history and investigated symptoms associated with long COVID diagnosis in the UK.

11 Jan 2023

Sugar appears to play a role in polycystic kidney disease, study finds

A study of kidney organoids in a novel lab environment might have downstream implications for the treatment of polycystic kidney disease (PKD), an incurable condition that affects more than 12 million people worldwide.

5 Jan 2023

Study assesses microbiome of male genital mucosa

A new study in the journal Microorganisms aimed to identify and analyze studies on the composition of the microbial community on different parts of the healthy and diseased male genital mucosa.

4 Jan 2023

Physicians reveal main risk factors for sudden death from a colloid cyst

RUDN University physicians investigated known cases of sudden death from a colloid cyst. After analyzing the data, the authors named the main risk factors and told what to look for. The results are published in the Journal of Clinical Neuroscience.

22 Dec 2022

Experts provide first framework for treating hypercalcemia of malignancy in adults

Experts provide the first framework for treating a common and life-threatening metabolic complication of cancer known as hypercalcemia of malignancy in the Endocrine Society's new Clinical Practice Guideline.

21 Dec 2022

Review on nanoparticles usage for treating thrombosis induced by SARS-CoV-2 infections

Researchers provided an overview of nanomedicine strategies to treat coronavirus disease 2019 (COVID-19)-induced thrombosis.

21 Dec 2022

Exposure to blue-green algae toxin shown to wreak havoc on gut bacteria and cause liver damage

Exposure to a specific type of blue-green algae toxin known as cylindrospermopsin has shown to wreak havoc on gut bacteria and an increased probability of irritable bowel syndrome, inflammatory bowel disease, celiac disease, type 1 diabetes, obesity and inflammation of the liver – a precursor to liver cancer – according to a study led by the University of California, Irvine.

20 Dec 2022

New support for a serotonin deficit in depression

Since the 1960s, researchers have postulated that major depression stems from disruptions in the serotonin neurotransmitter system, but the evidence for that idea, though plentiful, was indirect.

16 Dec 2022

Researchers develop transgenic mice with the FRET biosensor for in vivo observation of necroptosis

Necroptosis is a form of regulated cell death (RCD) similar to apoptosis, the most commonly studied type of RCD. In contrast to apoptosis, plasma membrane rupture in necroptotic cells occurs at early time points.

9 Dec 2022

Genetic predisposition to ADHD can predict risk of late-onset Alzheimer's disease

Genetic predisposition to attention-deficit/hyperactivity disorder (ADHD) can predict cognitive decline and Alzheimer's disease later in life, revealed an analysis published today in Molecular Psychiatry by University of Pittsburgh School of Medicine researchers.

8 Dec 2022

Machine learning analysis suggests that there are four sub-phenotypes of long COVID

Researchers identified PASC [post-acute sequelae of coronavirus disease 2019 (COVID-19)] sub-phenotypes depending on conditions diagnosed within 1 to 3 months of acute infection by SARS-CoV-2.

6 Dec 2022

Study explores histopathological, serological, and clinical characteristics of PASC in patients with mild COVID-19

Researchers investigated the clinical, histopathological, imaging, and serological characteristics of post-acute sequelae of coronavirus disease 2019 (COVID-19) (PASC) in patients with mild COVID-19.

5 Dec 2022

Comparison of blood plasma protein expression in mild, moderate, and severe COVID-19 identifies novel disease severity biomarkers

Researchers evaluated blood plasma proteins to identify new targets for COVID-19 treatment approaches and prevent complications associated with severe illness.

5 Dec 2022

Pathophysiology News and Research

What are the major findings of long COVID research?

Acquired mutations in 'Guardian of the Genome' accelerate the development of atherosclerosis

Protein heat shock transcription factor 1 may be a viable therapeutic target for hepatoblastoma

New blood test tracks neurodegenerative changes specifically in Alzheimer's disease

The impact of early life microbial colonization and respiratory diseases on the respiratory microbiome

IBS-related changes revealed using real time recording with a wearable device

2022: a year in MIS-C research

Study suggests many symptoms are more common after COVID-19 infection, but only a few are commonly associated with a long COVID diagnosis

Sugar appears to play a role in polycystic kidney disease, study finds

Study assesses microbiome of male genital mucosa

Physicians reveal main risk factors for sudden death from a colloid cyst

Experts provide first framework for treating hypercalcemia of malignancy in adults

Review on nanoparticles usage for treating thrombosis induced by SARS-CoV-2 infections

Exposure to blue-green algae toxin shown to wreak havoc on gut bacteria and cause liver damage

New support for a serotonin deficit in depression

Researchers develop transgenic mice with the FRET biosensor for in vivo observation of necroptosis

Genetic predisposition to ADHD can predict risk of late-onset Alzheimer's disease

Machine learning analysis suggests that there are four sub-phenotypes of long COVID

Study explores histopathological, serological, and clinical characteristics of PASC in patients with mild COVID-19

Comparison of blood plasma protein expression in mild, moderate, and severe COVID-19 identifies novel disease severity biomarkers

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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