Pathophysiology News and Research

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Simple, minimally-invasive tool to study nasal airways of cystic fibrosis patients

A paper published today in Science Translational Medicine describes a simple, minimally invasive new tool for viewing differences in the nasal airways of cystic fibrosis patients in vivo at a cellular level.

8 Aug 2019

New blinking eye-on-a-chip can be used for disease modeling and drug testing

People who spend eight or more hours a day staring at a computer screen may notice their eyes becoming tired or dry, and, if those conditions are severe enough, they may eventually develop dry eye disease.

5 Aug 2019

Research uncovers novel connections between liver dysfunction and Alzheimer's disease

New research from the Alzheimer's Disease Metabolomics Consortium and Alzheimer's Disease Neuroimaging Initiative has uncovered novel connections between liver dysfunction and Alzheimer's disease, paving a new path toward a systems level view of Alzheimer's relevant for early detection and ultimately for prevention.

31 Jul 2019

Fungus used in traditional medicine could slow neuron loss in ALS

A Chinese caterpillar fungus that is used in traditional Chinese medicine has been found to minimize motor neuron loss in mice models of ALS.

25 Jul 2019

UTA scientists part of NIH-funded study of precision therapy for HFpEF patients

Nearly half of all heart failure patients do not have effective treatments for their condition, so three researchers at The University of Texas at Arlington are taking a more precise approach.

23 Jul 2019

Study: Treatment of psychosis can be targeted to specific genetic mutation

Treatment of psychosis can be targeted to a specific genetic mutation in patients with psychotic disorders, according to a study in Biological Psychiatry, published by Elsevier.

4 Jul 2019

Targeted treatment offers symptom relief for patients with psychosis

Treatment for individuals who experience psychosis, such as hallucinations and delusions as a result of a psychiatric illness, can be targeted to a specific structural mutation, according to a study published by researchers from McLean Hospital and other institutions in the journal Biological Psychiatry.

3 Jul 2019

Interdisciplinary workgroup outlines what is known and unknown about paradoxical lucidity

It happens unexpectedly: a person long thought lost to the ravages of dementia, unable to recall the events of their lives or even recognize those closest to them, will suddenly wake up and exhibit surprisingly normal behavior, only to pass away shortly thereafter.

29 Jun 2019

Making Bacterial Infections a Thing of the Past for Chronic Respiratory Conditions

In this interview, Prof. Elborn and Dr. Dixon discuss the issues involving chronic lung conditions such as cystic fibrosis and bacterial respiratory infections.

From Neem Biotech 25 Jun 2019

More screening and new treatments needed for sickle cell disease

The promise of new treatments for sickle cell disease, a group of inherited red blood cell disorders, has never been so great, but it will only be realized if there is constant investment in health policies such as programs for screening newborns, especially in sub-Saharan Africa, where most cases occur.

13 Jun 2019

A million a day: STIs are a worldwide epidemic, declares WHO

STIs continue to rise globally, with more than 1 million new STIs of just four types being reported every day, according to a new report from the World Health Organization (WHO). This comes to over 376 million new STIs a year among people between 15 and 49 years.

6 Jun 2019

Scientists highlight advances and uses of organoids in gastroenterology and hepatology

One of the most exciting advancements in stem cell research has been the development of organoid systems, which are organ-like three-dimensional structures that mimic their corresponding organ in vivo.

4 Jun 2019

Five new genetic risk loci associated with maximum habitual alcohol use identified

A genome-wide association study has identified five new genetic risk loci that can pass on risk for harmful alcohol use from parents to children, and confirmed one previously identified risk locus.

28 May 2019

KAIST research team finds cause of sepsis-induced lung injury

A KAIST research team succeeded in visualizing pulmonary microcirculation and circulating cells in vivo with a custom-built 3D intravital lung microscopic imaging system.

7 May 2019

Cannabis, Alcohol and the Epigenome

With the legalization of cannabis in many US states, we explore the epigenetic effects of cannabis, cannabis-derived products, and alcohol.

29 Apr 2019

New research on psychological and neural basis of Post-Traumatic Stress Disorder

Dr. Stephen Maren, University Distinguished Professor in the Department of Psychological & Brain Sciences, recently published significant research on the psychological and neural basis of Post-Traumatic Stress Disorder.

12 Apr 2019

The two-hit model can lead to better understanding of heart failure

Nearly half of current hospital admissions for heart failure are caused by a type of the disease with no treatment options. Cardiology researchers at UT Southwestern Medical Center are changing that reality with a fresh approach, recently published in Nature.

12 Apr 2019

Bronchiectasis patients often display high sensitivity to airborne allergens

An international research team led by Nanyang Technological University, Singapore (NTU Singapore) has found that patients with the lung disease bronchiectasis also often display sensitivity to airborne allergens, and has highlighted the particular role that fungi appear to play.

4 Apr 2019

Study: Pathogenetic downregulation of adenosine linked to restless leg syndrome

Researchers have identified a common mechanism implicating adenosine in the cause of restless leg syndrome symptoms — the periodic limb movements characteristic of RLS and the state of enhanced arousal that both disrupt sleep.

4 Apr 2019

Study identifies gene variant associated with accelerated cellular aging

It is well known that psychiatric stress is associated with accelerated aging. Now, a new study shows that a gene mutation interacts with multiple types of psychiatric stress including post-traumatic stress disorder (PTSD), pain and sleep disturbances in association with cellular aging.

20 Mar 2019