Pathophysiology News and Research

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Early sepsis detection: molecular immune markers show limited impact in screening tools

Researchers evaluated the additional predictive value of molecular immune markers with the Predict Sepsis screening tools developed previously by the same research team.

13 Sep 2023

How COVID-19 targets the pancreas revealed

The study uncovers the role of the PLAC8 protein in making the human pancreas vulnerable to SARS-CoV-2 infection, leading to pancreatic injury and complications in severe COVID-19 cases. The findings open up new avenues for understanding how the virus affects multiple organ systems and offer a potential target for future treatments.

12 Sep 2023

SARS-CoV-2 infection can exacerbate production of auto-antibodies relating to auto-immune diseases

An article published in NPJ Aging, a Springer Nature journal, reveals that natural production of auto-antibodies increases with age and that infection by SARS-CoV-2 can exacerbate production of auto-antibodies relating to auto-immune diseases, helping to explain why aging increases the chances of developing severe COVID-19.

12 Sep 2023

Psoriasis vs. atopic dermatitis: New study reveals surprising inflammatory differences in age-specific groups

The hematological parameters and serum biomarkers of inflammation and immunity in patients with atopic dermatitis and psoriasis.

12 Sep 2023

Unlocking the genetic code of blood sugar reveals new diabetes risks and lung complications

The study used a genome-wide association study (GWAS) to analyze random glucose levels in nearly half a million non-diabetic subjects, uncovering 150 distinct genetic signals, including 53 new ones, linked to glycemic traits and type 2 diabetes. The research also discovered a causal effect of random glucose and type 2 diabetes on lung function, identifying lung dysfunction as a new diabetes complication.

10 Sep 2023

Is DNA methylation the missing link in diagnosing and treating psoriasis and psoriatic arthritis?

Researchers across Europe have delved into the DNA methylation patterns in CD4+ T-cells of psoriasis and psoriatic arthritis (PsA) patients, unveiling potential new biomarkers for these conditions. Their study suggests that these unique profiles could serve as both diagnostic and prognostic tools, although further validation is needed for real-world clinical application.

10 Sep 2023

3D bioprinting methods for fabricating bioengineered blood vessel models

A review paper by scientists at the Chonnam National University summarized the recent research on bioprinting methods for fabricating bioengineered blood vessel models.

8 Sep 2023

Ketogenic diet shows promise in addressing hormonal imbalance associated with PCOS

Researchers performed a meta-analysis on the impact of ketogenic diets on polycystic ovary syndrome (PCOS).

8 Sep 2023

Onset and prognosis of post-COVID-19 condition: A 2-Year observational study

Researchers conducted a prospective cohort analysis over two years.

8 Sep 2023

'Growing pains' in children may indicate the presence or risk of migraines

New research published in Headache reveals that, in children and adolescents, pain in the lower limbs-;what are often called "growing pains" by clinicians and are commonly attributed to rapid growth-;may indicate the presence or risk of migraines.

7 Sep 2023

Scientists elucidate mechanism behind early loss of vaccination protection in people with autoimmune disease

People who are treated with TNF-α inhibitors for their autoimmune disease such as Crohn's disease or rheumatoid arthritis lose their vaccination protection significantly earlier than average.

7 Sep 2023

Gut feeling: How your microbiome could be shaping your mental health

Researchers in Biological Psychiatry delve into the complex relationship between the gut microbiome and mental health disorders like depression and bipolar disorder. The study explores how not just gut bacteria, but also lesser-known gut microorganisms such as viruses, fungi, and parasites, play a pivotal role in mood disorders.

5 Sep 2023

How SARS-CoV-2 hijacks Fragile X proteins to fuel infection: New clues in COVID-19 and genetic disorders

Study explores the interaction between SARS-CoV-2's non-structural protein 3 (NSP3) and proteins related to Fragile X mental retardation (FMRPs), shedding light on COVID-19 pathophysiology. The research suggests that the virus exploits these host cell proteins for effective infection and possibly interferes with antiviral defense mechanisms, offering new insights into the genetic basis of Fragile X syndrome.

5 Sep 2023

Gut microbes play a starring role in insulin resistance, opening doors for new diabetes treatments

The study reveals a strong association between gut microbial carbohydrate metabolism and insulin resistance, pointing to gut microbes as a key player in metabolic syndrome and type 2 diabetes. Targeting these microbial activities could offer a new therapeutic pathway for improving insulin resistance and overall metabolic health.

4 Sep 2023

The efficacy and safety of anti-androgens in the management of hormonal and clinical features of PCOS

The safety and efficacy of anti-androgens in managing polycystic ovary syndrome (PCOS).

1 Sep 2023

Maternal high-fat diet may alter airway nerves in offspring, leading to asthma

New research points to a novel potential mechanism behind eating a high-fat diet during pregnancy and asthma in the offspring.

31 Aug 2023

Novel non-invasive model may help predict preeclampsia before symptoms

Researchers developed a novel clinical diagnostic screening test to identify pregnancies at risk of developing preeclampsia.

31 Aug 2023

Anesthesiologists can play a greater role in managing patients with substance use disorders

As use and misuse of alcohol, opioids, and psychostimulants continues to increase, anesthesiologists can become a more integral part of the care team managing patients with a Substance Use Disorder (SUD), according to a series of three articles published in the September issue of Anesthesia & Analgesia, the official journal of the International Anesthesia Research Society.

24 Aug 2023

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Researchers described the preclinical profile of JT002, a novel and orally bioavailable small molecule inhibitor of the NLRP3 inflammasome.

24 Aug 2023

Alcohol-associated bowel disease: A review of the literature

Alcohol consumption is a significant risk factor for gastrointestinal diseases, including cancer. Alcohol can damage the gastrointestinal tract in several ways.

21 Aug 2023

Pathophysiology News and Research

Early sepsis detection: molecular immune markers show limited impact in screening tools

How COVID-19 targets the pancreas revealed

SARS-CoV-2 infection can exacerbate production of auto-antibodies relating to auto-immune diseases

Psoriasis vs. atopic dermatitis: New study reveals surprising inflammatory differences in age-specific groups

Unlocking the genetic code of blood sugar reveals new diabetes risks and lung complications

Is DNA methylation the missing link in diagnosing and treating psoriasis and psoriatic arthritis?

3D bioprinting methods for fabricating bioengineered blood vessel models

Ketogenic diet shows promise in addressing hormonal imbalance associated with PCOS

Onset and prognosis of post-COVID-19 condition: A 2-Year observational study

'Growing pains' in children may indicate the presence or risk of migraines

Scientists elucidate mechanism behind early loss of vaccination protection in people with autoimmune disease

Gut feeling: How your microbiome could be shaping your mental health

How SARS-CoV-2 hijacks Fragile X proteins to fuel infection: New clues in COVID-19 and genetic disorders

Gut microbes play a starring role in insulin resistance, opening doors for new diabetes treatments

The efficacy and safety of anti-androgens in the management of hormonal and clinical features of PCOS

Maternal high-fat diet may alter airway nerves in offspring, leading to asthma

Novel non-invasive model may help predict preeclampsia before symptoms

Anesthesiologists can play a greater role in managing patients with substance use disorders

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Alcohol-associated bowel disease: A review of the literature

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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