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Prefrontal cortex in the brain damaged by both alcoholism and chronic smoking

Alcoholism is commonly associated with chronic smoking, and both alcohol and nicotine are believed to act on the same brain region. Research builds upon previous research that identified four potential alcohol-sensitive genes in the prefrontal cortex, finding that smoking also influences the expression of these genes.

26 Apr 2006

Protein mutated in cancer found to be linked to diabetes

A study published by Nature has defined the function of p110 alpha, the flag-ship molecule of the eight member PI3K family, which is one of the most frequently activated pathways in cancer. The function of p110 alpha in the body has eluded researchers for over a decade but a new approach to generating mouse models, has allowed investigators to solve the mystery and yield important information for planned clinical trials with PI3K inhibitors.

25 Apr 2006

Enzyme research points to better drugs and improved industrial processes

Groundbreaking enzyme research could revolutionise the way drugs are made and have major implications for the industrial sector, including brewing, food processing, domestic cleaning and paper manufacturing.

From The University of Manchester 25 Apr 2006

How much advice on mental illness treatment is influenced by drug companies?

According to new research in the U.S. most of the experts giving advice on the diagnosis and management of mental illness have had financial links to drug makers such as research funding or stock holdings.

23 Apr 2006

Surgical robot makes prostate removal safe for obese men

The use of a robotic system could make surgery for prostate cancer an option for thousands of obese men who might otherwise be turned down, report researchers from the University of Chicago in the April 2006 issue of the journal Urology.

20 Apr 2006

Convictions in $45 million illegal blood diversion scheme

Florida pharmaceutical wholesale distributor, convicted on March 29, 2006, of more than two hundred and forty-seven criminal counts as the result of an extensive OCI investigation of an illegal medical products diversion scheme which defrauded the Medicaid and Medicare programs of more than $45,000,000.

19 Apr 2006

New London based centre for clinical genetic research

The London Genetics Centre will provide access to knowledge and expertise in clinical genetics across London's biomedical institutions, and help position London as the leading European centre for genetic medicine.

19 Apr 2006

Primagen awarded U.S. patent for using mitochondrial DNA quantification as biomarker

Primagen Holding BV has announced that the U.S. Patent and Trademark Office has granted a patent for its Mitox mitochondrial DNA quantification technology as biomarkers for efficacy and adverse events of treatment.

19 Apr 2006

Short acting insulin analogues versus regular human insulin in patients with diabetes mellitus

Fast-acting artificial insulin drugs work just as well as regular human insulin, but it's unclear how they could affect the health of people with diabetes over the long run, according to a new review of recent studies.

18 Apr 2006

Researchers clarify the mechanism by which drugs like Celebrex and Vioxx cause heart problems

Researchers at the University of Pennsylvania School of Medicine have clarified the mechanism by which drugs like Celebrex and Vioxx cause heart problems, in multiple animal models.

18 Apr 2006

Sticky proteins for neuro-chip chat

EU-funded researchers have taken the firsts steps towards future technologies combining silicon circuits and the nervous systems of mammals. Applications could include advanced drug screening and, perhaps one day, implants to help combat neurological disorders.

18 Apr 2006

Osteoporosis drug Raloxifene shown to be as effective as Tamoxifen in preventing invasive breast cancer

Initial results of the Study of Tamoxifen and Raloxifene, or STAR, show that the drug raloxifene, currently used to prevent and treat osteoporosis in postmenopausal women, works as well as tamoxifen in reducing breast cancer risk for postmenopausal women at increased risk of the disease.

18 Apr 2006

First gene therapy human trial in the United States for a form of muscular dystrophy under way

The clinical trial for Duchenne muscular dystrophy (DMD) tests the safety and effectiveness of a therapy that was developed over two decades by scientists at the University of North Carolina Chapel Hill's School of Medicine and the University of Pittsburgh.

16 Apr 2006

Simple screening process opens door to treating rare metabolic diseases such as Tay-Sachs, Fabry and Gaucher syndromes

Rare metabolic diseases such as Tay-Sachs, Fabry and Gaucher syndromes are caused by enzyme deficiencies and typically have crippling, even fatal, consequences starting at very early ages.

13 Apr 2006

Research provides clues to obesity's cause

Hot fudge sundaes and french fries aside, new research suggests obesity is due at least in part to an attraction between leptin, the hormone that signals the brain when to stop eating, and a protein more recently associated with heart disease.

13 Apr 2006

Drug firms in the business of 'diseasemongering'

Australian scientists have accused drug companies of inventing diseases to sell more of their products.

12 Apr 2006

Single dose of stem cells produce robust behavioral recovery in animal models for stroke, cerebral palsy

A single dose of adult donor stem cells given to animals that have neurological damage similar to that experienced by adults with a stroke or newborns with cerebral palsy can significantly enhance recovery from these types of injuries, researchers say.

11 Apr 2006

St. John's wort and Echinacea increase activity of enzyme in the liver and intestine

St. John's wort and Echinacea, two widely-used herbal preparations, have been found to increase activity of a specific enzyme in the liver and intestine, an enzyme involved in the metabolization of roughly one in every four pharmaceutical drugs on the market today, reports a clinical pharmacologist at Indiana University School of Medicine.

11 Apr 2006

Researchers unravel structure of important new drug target that could potentially treat SARS-infected patients

Mesecar said that the knowledge gained from this new atomic structure - the first-ever reported on this class of proteases - has the potential to go beyond the treatment of patients infected with the coronavirus that causes SARS.

11 Apr 2006

Colorimetric screening detects DNA, small molecules and proteins

Using the unusual color properties of gold at the nanoscale, scientists at Northwestern University have developed a "litmus test" for DNA and small molecule binding that eventually could be used by pharmaceutical companies to rapidly identify promising candidates for new anti-cancer drugs.

11 Apr 2006

Pharmaceuticals News and Research

Prefrontal cortex in the brain damaged by both alcoholism and chronic smoking

Protein mutated in cancer found to be linked to diabetes

Enzyme research points to better drugs and improved industrial processes

How much advice on mental illness treatment is influenced by drug companies?

Surgical robot makes prostate removal safe for obese men

Convictions in $45 million illegal blood diversion scheme

New London based centre for clinical genetic research

Primagen awarded U.S. patent for using mitochondrial DNA quantification as biomarker

Short acting insulin analogues versus regular human insulin in patients with diabetes mellitus

Researchers clarify the mechanism by which drugs like Celebrex and Vioxx cause heart problems

Sticky proteins for neuro-chip chat

Osteoporosis drug Raloxifene shown to be as effective as Tamoxifen in preventing invasive breast cancer

First gene therapy human trial in the United States for a form of muscular dystrophy under way

Simple screening process opens door to treating rare metabolic diseases such as Tay-Sachs, Fabry and Gaucher syndromes

Research provides clues to obesity's cause

Drug firms in the business of 'diseasemongering'

Single dose of stem cells produce robust behavioral recovery in animal models for stroke, cerebral palsy

St. John's wort and Echinacea increase activity of enzyme in the liver and intestine

Researchers unravel structure of important new drug target that could potentially treat SARS-infected patients

Colorimetric screening detects DNA, small molecules and proteins

Drug Discovery - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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