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Study uncovers new immune target to treat atherosclerosis

For the longest time, clinicians have treated cardiovascular disease by focusing on diabetes and blood pressure control, reducing cholesterol using medications like aspirin and statins.

16 Dec 2022

Four genetic mutations linked to progressive multifocal leukoencephalopathy

New research has confirmed a strong link between four genetic mutations and progressive multifocal leukoencephalopathy (PML), a rare but often fatal brain infection that can be triggered by dozens of FDA-approved drugs.

14 Dec 2022

States challenge Biden to lower drug prices by allowing imports from Canada

The Biden administration is facing mounting pressure from states to let them import medicine from Canada to help lower prescription drug costs.

14 Dec 2022

Novel drug shows early potential in combating multiple myeloma

A first-of-its-kind drug known as modakafusp alfa has shown early potential in combating multiple myeloma, a form of bone marrow cancer, in a study presented by researchers from the University of Pennsylvania's Abramson Cancer Center at the 2022 American Society of Hematology Annual Meeting (Abstract 565).

12 Dec 2022

In rural America, deadly costs of opioids outweigh the dollars tagged to address them

Tim Buck knows by heart how many people died from drug overdoses in his North Carolina county last year: 10. The year before it was 12 — an all-time high.

12 Dec 2022

Discovery of cellular uptake pathway for larger molecules can be harnessed to create new drugs

A fundamental challenge in drug development is the balance between optimizing a drug's lock-and-key fit with its target and the drug's ability to make its way across the cellular membrane and access that target.

8 Dec 2022

T-DXd leads to longer overall survival in HER2-positive metastatic breast cancer patients than T-DM1

Second-line treatment with trastuzumab deruxtecan (T-DXd) led to significantly longer overall survival compared with trastuzumab emtansine (T-DM1) in patients with HER2-positive metastatic breast cancer, according to updated results from the DESTINY-Breast03 phase III clinical trial presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

7 Dec 2022

Study reports overall response of HER2-low breast cancer patients to neoadjuvant T-DXd treatment

Patients with localized, hormone receptor-positive, HER2-low breast cancer treated with trastuzumab deruxtecan (T-DXd, Enhertu) in the neoadjuvant setting had an overall response rate of 75 percent in the absence of anastrozole and 63 percent in combination with anastrozole, according to results from the phase II TRIO-US B-12 TALENT trial presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

7 Dec 2022

Paxlovid has been free so far. Next year, sticker shock awaits.

Nearly 6 million Americans have taken Paxlovid for free, courtesy of the federal government. The Pfizer pill has helped prevent many people infected with covid-19 from being hospitalized or dying, and it may even reduce the risk of developing long covid.

7 Dec 2022

Trial shows acoziborole drug clears body of African sleeping sickness parasites

Researchers evaluate the efficacy and safety of an oral antimicrobial drug acoziborole in patients with human African trypanosomiasis.

4 Dec 2022

The business of clinical trials is booming. Private equity has taken notice.

After finding success investing in the more obviously lucrative corners of American medicine — like surgery centers and dermatology practices — private equity firms have moved aggressively into the industry's more hidden niches: They are pouring billions into the business of clinical drug trials.

2 Dec 2022

Watch: The politics of health care in California

KHN senior correspondent Angela Hart joined the nonpartisan group Democracy Winters on Nov. 19 to discuss the politics of health care in California.

2 Dec 2022

KHN’s ‘What the Health?’: Medicaid machinations

The lame-duck Congress is back in Washington with a long list of bills it would like to pass and a short time to do it before Republicans take over the House majority in January.

1 Dec 2022

Research finds higher rate of rare tandem repeats in the genomes of individuals with schizophrenia

In our cells, the language of DNA is written, making each of us unique. A tandem repeat occurs in DNA when a pattern of one or more nucleotides – the basic structural unit of DNA coded in the base of chemicals cytosine (C), adenine (A), guanine (G) and thymine (T) – is repeated multiple times in tandem. An example might be: CAG CAG CAG, in which the pattern CAG is repeated three times.

30 Nov 2022

£12 million awarded to innovative UK regulators to help drive technology and personalized medicine

Science Minister George Freeman has today (30 November) awarded up to £12 million to UK regulators to help drive forward innovation, remove red tape and establish the UK as world leader in technologies of the future - from AI to help treat rare diseases, to drones monitoring safety on construction sites.

30 Nov 2022

New computer-based platform could make drug discovery process more efficient and less expensive

Researchers at The University of Texas at Dallas and Novartis Pharmaceuticals Corp. have devised a computer-based platform for drug discovery that could make the process more effective, more efficient and less costly.

28 Nov 2022

Study: Nearly 1 in 7 Americans regularly experience bloating issues

Nearly 1 in 7 Americans experience bloating on a weekly basis, and most aren't seeking professional care for it, according to a new study led by Cedars-Sinai investigators.

24 Nov 2022

Researchers make an incredible discovery about mammalian brains

In a new breakthrough to understand more about the mammalian brain, University of Copenhagen researchers have made an incredible discovery.

23 Nov 2022

A simple method to prepare carbon isotope-labeled versions of drugs and diagnostics

Dr. Benjamin Rotstein and collaborators unveil an operationally simple method to prepare carbon isotope-labeled versions of drugs and diagnostics.

22 Nov 2022

Unexpected declines in cognitive performance after epilepsy surgery

In severe epilepsies, surgical intervention is often the only remedy - usually with great success. While neuropsychological performance can recover in the long term after successful surgery, on rare occasions, unexpected declines in cognitive performance occur.

22 Nov 2022

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Pharmaceuticals News and Research

Study uncovers new immune target to treat atherosclerosis

Four genetic mutations linked to progressive multifocal leukoencephalopathy

States challenge Biden to lower drug prices by allowing imports from Canada

Novel drug shows early potential in combating multiple myeloma

In rural America, deadly costs of opioids outweigh the dollars tagged to address them

Discovery of cellular uptake pathway for larger molecules can be harnessed to create new drugs

T-DXd leads to longer overall survival in HER2-positive metastatic breast cancer patients than T-DM1

Study reports overall response of HER2-low breast cancer patients to neoadjuvant T-DXd treatment

Paxlovid has been free so far. Next year, sticker shock awaits.

Trial shows acoziborole drug clears body of African sleeping sickness parasites

The business of clinical trials is booming. Private equity has taken notice.

Watch: The politics of health care in California

KHN’s ‘What the Health?’: Medicaid machinations

Research finds higher rate of rare tandem repeats in the genomes of individuals with schizophrenia

£12 million awarded to innovative UK regulators to help drive technology and personalized medicine

New computer-based platform could make drug discovery process more efficient and less expensive

Study: Nearly 1 in 7 Americans regularly experience bloating issues

Researchers make an incredible discovery about mammalian brains

A simple method to prepare carbon isotope-labeled versions of drugs and diagnostics

Unexpected declines in cognitive performance after epilepsy surgery

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Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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