Phosphatase News and Research

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Scientists use new drug discovery system to target Huntington’s Disease

Scientists have used a new drug discovery system to specifically target phosphatases in Huntington's, which were previously thought to be undruggable.

27 Jul 2018

Scientists use new drug discovery system to target Huntington’s Disease

Scientists have used a new drug discovery system to specifically target phosphatases in Huntington's, which were previously thought to be undruggable.

27 Jul 2018

New drug discovery system allows scientists to target ‘undruggable’ enzymes

A new drug discovery system allows scientists to specifically target members of an important family of enzymes, called phosphatases, which were previously considered mostly "undruggable".

27 Jul 2018

Protein researchers identify several new potential targets for cancer

In a new study based on mouse cells internationally leading protein researchers have identified several new potential targets using state-of-the-art technology, many of which could be employed for future treatment of different types of cancers and diseases.

14 May 2018

OCA treatment stabilizes or reverses fibrosis/cirrhosis in patients with primary biliary cholangitis

The first results from the POISE biopsy sub-study have today confirmed that long-term treatment with obeticholic acid leads to the reversal or stabilization of fibrosis/cirrhosis in patients with primary biliary cholangitis who have had an incomplete response to ursodeoxycholic acid.

13 Apr 2018

Salk scientists discover protein that 'turns off' uncontrolled liver cancer growth

Salk Institute scientists, together with researchers from Switzerland's University of Basel and University Hospital Basel, discovered a protein called LHPP that acts as a molecular switch to turn off the uncontrolled growth of cells in liver cancer.

29 Mar 2018

Study finds first evidence of delayed aging among Americans

Americans may be aging more slowly than they were two decades ago. A new study by University of Southern California and Yale University researchers suggests that at least part of the gains in life expectancy over recent decades may be due to a change in the rate of biological aging, rather than simply keeping ailing people alive.

16 Mar 2018

InSysBio evaluates tau protein phosphorylation related targets for treatment of AD

InSysBio continues to investigate the mechanisms underlying Alzheimer's disease using the quantitative systems pharmacology modeling approach. The part of QSP model describing tau protein was published in the PLOS ONE journal. This is one of more than dozen InSysBio publications in AD area during last seven years.

28 Feb 2018

Highly sensitive ELISA method for analysis of CET in plasma samples

This article explores the development, full optimization and validation study of a highly sensitive and selective ELISA for determination of cetuximab (CET) in human plasma samples.

23 Feb 2018

Research project succeeds in palliating kidney disease caused by diabetes in mice

Diabetes has become a major health problem worldwide; some estimates suggest that in twenty years' time there will be around 600 million diabetics. The disease is caused by impaired insulin secretion, which in turn hinders cell glucose uptake; as a result, sugar levels in the bloodstream remain excessively high.

8 Feb 2018

Researchers uncover novel therapeutic target for type 2 diabetes

Researchers from Kanazawa University and the National Center for Global Health and Medicine in Tokyo report, in Nature Communications, a new mechanism for regulating glucose uptake by the liver which has implications for type 2 diabetes and its treatment.

6 Feb 2018

Researchers identify potential enzyme as therapeutic target for type 2 diabetes

Abnormalities in glucose uptake by the liver (or hepatic glucose uptake; HGU) cause elevations in blood glucose levels following meals, a state that is known as postprandial hyperglycemia.

27 Jan 2018

New recommendations aim to improve diagnosis of liver disease, prevent unnecessary tests

New recommendations, led by experts at the University of Birmingham, have been published to improve the use of liver blood tests.

20 Dec 2017

UNIGE scientists unravel key role played by the liver in onset of type-2 diabetes

Affecting as many as 650 million people worldwide, obesity has become one of the most serious global health issues. Among its detrimental effects, it increases the risk of developing metabolic conditions, and primarily type-2 diabetes.

28 Nov 2017

Stem cells do not participate directly in cartilage regeneration but serve to ‘animate’ the process

Stem cell therapy has great potential for curing cartilage damage. However, it has remained unclear whether stem cells are responsible for regeneration or whether they trigger the process.

31 Oct 2017

Rutgers scientists shed light on fat-regulating enzyme’s role in human health

It had already been known that the enzyme known as phosphatidic acid phosphatase plays a crucial role in regulating the amount of fat in the human body. Controlling it is therefore of interest in the fight against obesity.

20 Sep 2017

Pfizer receives FDA approval for new therapy to treat adults and children with AML

Pfizer Inc. today announced that the U.S. Food and Drug Administration approved MYLOTARG (gemtuzumab ozogamicin) for adults with newly diagnosed CD33-positive acute myeloid leukemia (AML), and adults and children 2 years and older with relapsed or refractory CD33-positive AML.

1 Sep 2017

Coffee consumption connected to a longer life

At the European Society of Cardiology, ESC Congress 1 last weekend, Spanish researchers working as part of the long term project Seguimiento Universidad de Navarra (SUN) Project, presented their new study that suggests coffee intake might be tied to a longer life. The study included around 20,000 Spanish participants.

28 Aug 2017

New strategy allows researchers to identify potential treatments for altered levels of MeCP2

Having twice the normal amount of the protein MeCP2, a condition called MECP2 duplication syndrome, causes severe progressive neuropsychiatric disorders that include intellectual disability, autism spectrum disorders, motor dysfunction and other medical complications.

24 Aug 2017

Biomedical scientist receives $1.83 million NIH grant for inflammatory bowel disease research

A biomedical scientist at the University of California, Riverside has received a $1.83 million grant to identify how the loss of a protective barrier in the intestine contributes to inflammatory bowel disease (IBD).

11 Aug 2017

Phosphatase News and Research

Scientists use new drug discovery system to target Huntington’s Disease

Scientists use new drug discovery system to target Huntington’s Disease

New drug discovery system allows scientists to target ‘undruggable’ enzymes

Protein researchers identify several new potential targets for cancer

OCA treatment stabilizes or reverses fibrosis/cirrhosis in patients with primary biliary cholangitis

Salk scientists discover protein that 'turns off' uncontrolled liver cancer growth

Study finds first evidence of delayed aging among Americans

InSysBio evaluates tau protein phosphorylation related targets for treatment of AD

Highly sensitive ELISA method for analysis of CET in plasma samples

Research project succeeds in palliating kidney disease caused by diabetes in mice

Researchers uncover novel therapeutic target for type 2 diabetes

Researchers identify potential enzyme as therapeutic target for type 2 diabetes

New recommendations aim to improve diagnosis of liver disease, prevent unnecessary tests

UNIGE scientists unravel key role played by the liver in onset of type-2 diabetes

Stem cells do not participate directly in cartilage regeneration but serve to ‘animate’ the process

Rutgers scientists shed light on fat-regulating enzyme’s role in human health

Pfizer receives FDA approval for new therapy to treat adults and children with AML

Coffee consumption connected to a longer life

New strategy allows researchers to identify potential treatments for altered levels of MeCP2

Biomedical scientist receives $1.83 million NIH grant for inflammatory bowel disease research

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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