Phosphorylation News and Research

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Researchers find STAT3 as therapeutic target for chronic active EBV infection

Tokyo Medical and Dental University study shows that ruxolitinib-induced inhibition of STAT3 activity blocks survival and reduces pro-inflammatory cytokine production in Epstein-Barr virus (EBV)-infected clonally proliferating T- or NK-cells in Chronic active Epstein-Barr virus infection.

20 Aug 2018

Scientists discover key vulnerability of mixed lineage leukemia

Childhood leukemia is a diagnosis that no family ever wants to endure. While the treatment of most types of leukemia has improved steadily over the years, a few specific types remain very difficult to treat.

13 Aug 2018

Researchers discover molecule essential for guiding axon to its destination

While today's technology is growing increasingly wireless, nature's greatest technology, the human brain, still depends on neurons being directly connected to one another.

9 Aug 2018

Silencing of GULP1 gene expression plays important role in ovarian carcinogenesis

Johns Hopkins researchers in collaboration with Insilico Medicine, a biotechnology company based in Rockville Maryland, identify that silencing of the GULP1 gene expression by methylation plays an important role in ovarian carcinogenesis.

7 Aug 2018

Researchers find ways to render curcumin soluble and deliver it to infected tumors

In India and other countries in Southeast Asia, curcumin is often used as a spice in cooking, particularly chicken or fish. It is known for its therapeutic effect and as a way to kill germs present in raw meet.

7 Aug 2018

Restoring mitochondrial function to reverse aging-related skin wrinkles, hair loss in mice

Wrinkled skin and hair loss are hallmarks of aging. What if they could be reversed?

20 Jul 2018

Scientists demonstrate a new regulation mechanism for skeletal muscles

An international team of scientists from the University of Florence, Italy and the Randall Division in collaboration with the ESRF, the European Synchrotron, Grenoble, France, demonstrated a new regulation mechanism for skeletal muscle.

20 Jul 2018

Study delves into the role played by Protein Kinase C in synaptic plasticity

Inside the brain, is a complex symphony of perfectly coordinated signaling. Hundreds of different molecules amplify, modify and carry information from tiny synaptic compartments all the way through the entire length of a neuron.

17 Jul 2018

Research reveals new gears in the circadian clock

A long-studied factor controlling human sleep cycles actually has two forms, one that keeps a key protein stable and another that promotes its degradation.

12 Jul 2018

Researchers discover mechanism that shuts down cell-to-cell communications pathway

Cellular functions rely on several communications networks that allow cells to rapidly respond to signals affecting the organism.

10 Jul 2018

Scientists discover the molecular trigger of necroptosis

Researchers have uncovered a trigger for an immune-related cell death pathway called necroptosis. The discovery could be used to develop new treatments for cancer and immune disorders.

21 Jun 2018

Study sheds new light on how the food we eat affects biochemical signals in the gut

For years, researchers have studied how the body's microbiome impacts virtually every aspect of human health ranging from the immune system to mental wellness.

5 Jun 2018

Intermittent fasting may increase diabetes risk, shows study

Fasting every other day to lose weight impairs the action of sugar-regulating hormone, insulin, which may increase diabetes risk, according to data presented in Barcelona at the European Society of Endocrinology annual meeting, ECE 2018.

21 May 2018

Scientists discover culprit in reducing effectiveness of insulin

Scientists at Osaka University discovered that Stromal derived factor-1 (SDF-1) secreted from adipocytes reduced the effectiveness of insulin in adipocytes and decreased insulin-induced glucose uptake.

25 Apr 2018

Roswell Park researchers identify driver of cancer-promoting metabolic changes

Roswell Park Comprehensive Cancer Center researchers have identified a potential key player promoting cancer progression through changes in the cell environment that are conducive to metastasis.

17 Apr 2018

Researchers discover potential new therapeutic target for Ewing sarcoma

The sarcoma research group of the Bellvitge Biomedical Research Institute, led by Dr. Òscar Martínez-Tirado, has identified a potential new therapeutic target for Ewing sarcoma, the second most frequent bone cancer in children and adolescents, and a tumor known by its aggressiveness and tendency to metastasize.

5 Apr 2018

New discovery may offer insight into treating sickle cell anemia and other blood disorders

Discovery by Scripps Research scientists may offer insight into treating blood disorders such as sickle cell anemia.

4 Apr 2018

Salk scientists discover protein that 'turns off' uncontrolled liver cancer growth

Salk Institute scientists, together with researchers from Switzerland's University of Basel and University Hospital Basel, discovered a protein called LHPP that acts as a molecular switch to turn off the uncontrolled growth of cells in liver cancer.

29 Mar 2018

InSysBio evaluates tau protein phosphorylation related targets for treatment of AD

InSysBio continues to investigate the mechanisms underlying Alzheimer's disease using the quantitative systems pharmacology modeling approach. The part of QSP model describing tau protein was published in the PLOS ONE journal. This is one of more than dozen InSysBio publications in AD area during last seven years.

28 Feb 2018

International research collaboration finds genetic mutation linked to Crohn's disease

A genetic mutation was found to be associated with Crohn's disease. The discovery was made by international research collaboration and was published in the prestigious journal Science Translational Medicine.

8 Feb 2018