Platelets News and Research

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Decitabine improves myelodysplastic syndrome treatment

A potent member of a new class of drugs increases survival in some patients with myelodysplastic syndrome (MDS), and may become the new standard of therapy for this group of pre-cancer disorders

14 Mar 2006

Decitabine improves patient outcomes in myelodysplastic syndromes

Decitabine, a new drug undergoing Phase III efficacy trials, provides palliative therapy for patients with the bone marrow disease called Myelodysplastic Syndrome (MDS), according to a new study.

14 Mar 2006

SSRI use associated with increased risk for heart patients

In a surprising finding, patients with coronary artery disease who take commonly used antidepressant drugs may be at significantly higher risk of death, Duke University Medical Center researchers have found.

7 Mar 2006

New device to boost supply and quality of blood platelets

Cancer and open-heart surgery patients, disaster victims, organ or bone marrow transplant recipients, and others who require life-saving blood platelet transfusions will benefit from equipment invented by a researcher at the University of British Columbia's Centre for Blood Research (CBR).

21 Feb 2006

Polyphosphate speeds blood clotting and helps clots last longer

A serendipitous comparison prompted by an old scientific image and involving an ancient but understudied molecule may lead to a new treatment strategy for injuries or illnesses in which blood clotting is paramount to survival.

9 Jan 2006

Misdosing anti-clotting drugs leads to heart attack symptoms

Because of inaccuracies in prescribing, 42 percent of patients rushed to emergency rooms with symptoms of a heart attack received doses of powerful drugs intended stop clotting in coronary arteries outside of the recommended range, a new analysis by Duke Clinical Research Institute (DCRI) cardiologists has found.

28 Dec 2005

New treatment for chronic Immune Thrombocytopenic Purpura

Data from a Phase II study of eltrombopag, an oral investigational drug that increases the production of platelets, demonstrate that the compound was effective in increasing platelet counts in patients with chronic Immune Thrombocytopenic Purpura (ITP), a disorder characterized by episodes of frequent spontaneous bruising, mucosal bleeding, and in severe cases intracranial hemorrhage, and acute episodes of severe bleeding.

12 Dec 2005

Physicians slow to prescribe newer heart drugs

An analysis of the treatment received by more than 100,000 heart patients has shown that physicians' prescription practices for drugs proven effective for treating heart disease has shown steady improvement over the past three years, cardiologists at the Duke Clinical Research Institute (DCRI) have concluded.

7 Dec 2005

Low doses of aspirin increase chance of developing ulcers

Aspirin has long been hailed as one of the most effective, low-cost ways to help guard against a heart attack or stroke. However, international medical researchers caution that low doses of aspirin also increase a patient's chance of developing an ulcer, often without warning signs.

28 Nov 2005

Aspirin advice ignored by those who need it

A daily dose of aspirin is an inexpensive, proven strategy for reducing the likelihood of heart disease among those most at risk for such disorders, yet a new study from the Stanford University School of Medicine shows that aspirin therapy is being used by fewer than one-third of the U.S. outpatients who would benefit from it.

20 Nov 2005

Mixed carbon nanotubes and standard urban particulates suggests a risk of thrombosis from airborne pollution

Carbon nanoparticles - both those unleashed in the air by engine exhaust and the engineered structures thought to have great potential in medical applications - promote blood-clotting, scientists report in an upcoming edition of the British Journal of Pharmacology.

23 Oct 2005

New approaches to counteract platelet shortages

Availability of safe platelets is a fundamental blood transfusion challenge and can be especially problematic in times of emergency. Several studies presented at the annual American Association of Blood Banks (AABB) meeting today demonstrate new approaches to counteract platelet shortages by enhancing the safety of whole blood derived platelets, precluding the need to rely on only those obtained through apheresis.

17 Oct 2005

Gel made from a patient's own blood reduces pain and may improve wound healing

The study, published in the September issue of the Annals of Otology, Rhinology and Laryngology, found that patients who received platelet gel reported an easier recovery than patients who received traditional packing to stop bleeding.

13 Oct 2005

Moderate drinking has effects on blood coagulation, primarily as a "blood thinner"

Population studies have shown that moderate drinkers tend to have lower rates of heart disease but higher rates of bleeding-type strokes than abstainers. A potential mediator of these two contrasting effects of alcohol may be platelet function.

13 Oct 2005

Dental problems caused by radiation, chemotherapy should be treated before a child undergoes immunosuppression as part of bone marrow transplantation therapy

Many children who undergo bone marrow transplantation (BMT) as part of cancer treatment already have dental abnormalities that leave them vulnerable to potentially life-threatening bacterial infections, according to investigators at St. Jude Children's Research Hospital. A report on this study appears in the prepublication online edition of Bone Marrow Transplantation.

29 Aug 2005

Pre-mRNA that codes for inflammatory protein identified

In a discovery that upends a longstanding tenet of human biology, University of Utah School of Medicine researchers have shown that a key process in gene regulation can occur in human platelets, unique cells that are unusual because they don't have a nucleus (anucleate).

11 Aug 2005

Drinking a cup of cocoa can prevent potentially fatal blood clots

Throughout history, cocoa has been described as a medicine for many ailments. New research suggests that cocoa may also have a beneficial effect on heart disease and stroke.

9 Aug 2005

European approval of Temodal (temozolomide) capsules for treatment of glioblastoma multiforme

Schering-Plough announced today that the European Commission has granted approval of Temodal (temozolomide) Capsules for first-line use for the treatment of patients with newly diagnosed glioblastoma multiforme (GBM), the most common and aggressive form of primary brain cancer.

10 Jun 2005

Study shows how COX-2 inhibitors lead to heart disease

University of Pennsylvania School of Medicine researchers have found additional evidence that may help explain how selective inhibitors of COX-2 might predispose individuals to heart disease and stroke.

26 May 2005

Zevalin safe and effective for non-Hogdkin's lymphoma patients

According to a University of Pittsburgh Medical Center (UPMC) study, patients with advanced non-Hodgkin's lymphoma (NHL) previously treated with chemotherapy and adult stem cell transplantation can safely tolerate Zevalin (ibritumomab tiuxetan), a radiolabeled monoclonal antibody that targets radiation directly to a tumor.

17 May 2005