Preclinical News and Research

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Researchers examine role of high cholesterol in prostate cancer

Current research suggests that lowering cholesterol may block the growth of prostate tumors.

23 Feb 2009

Statins can stimulate cardiac muscle cell regeneration, improve heart function

Statins, used widely to treat elevated cholesterol, have been shown to prevent progression of coronary narrowing and to have other beneficial effects on the heart, such as reducing inflammation, that are independent of cholesterol.

23 Feb 2009

Bavarian Nordic updates on breast cancer vaccine studies

Bavarian Nordic today provided updated data from its clinical studies with its breast cancer vaccine, MVA-BN(R)-HER2, in development as therapy of metastatic breast cancer patients whose tumours over-express HER2.

23 Feb 2009

Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu

Scientists have identified a small family of lab-made proteins that neutralize a broad range of influenza A viruses, including the H5N1 avian virus, the 1918 pandemic influenza virus and seasonal H1N1 flu viruses.

22 Feb 2009

Neuralstem's ALS trial on hold

Neuralstem, Inc. has announced its spinal cord stem cell trial to treat Amyotrophic Lateral Sclerosis (ALS) is on clinical hold and that the Federal Drug Administration (FDA) has provided the Company with specific comments, questions and recommendations for modifications to its protocol.

22 Feb 2009

A stem cell bandage for your knee

Building on his previous work, Hollander and his team, which included Dr Wael Kafienah and Dr John Tarlton, announced in 2005 they had, for the first time ever, successfully grown human cartilage from a patient's own bone marrow stem cells.

18 Feb 2009

Radioimmunotherapy shows promise for HIV infection and viral cancers

Scientists at Albert Einstein College of Medicine of Yeshiva University have piggybacked antibodies onto radioactive payloads to deliver doses of radiation that selectively target and destroy microbial and HIV-infected cells.

16 Feb 2009

New device decreases wait times for patients needing immunotherapy

Researchers from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center have created a device that significantly decreases the time needed to produce genetically manipulated T cells in preclinical tests for leukemia.

16 Feb 2009

Trial of Quadramet (153 Samarium-lexidronam) in combo with Velcade shows positive results

Quadramet (153 Samarium-lexidronam) is a radioactive medication that targets the bone, specifically bone cancer, and is used to treat pain caused by cancer that has metastasized or spread to the bone.

15 Feb 2009

FDA approves clinical studies of novel anti-cancer drug developed by Italian researchers

Nerviano Medical Sciences (NMS) has secured Food and Drug Administration (FDA) approval to conduct for the first time clinical trials of a novel antitumoral agent.

10 Feb 2009

Endo Pharmaceuticals announces research collaborations on novel pain treatments and potential cancer treatments

Endo Pharmaceuticals has announced that it has signed two research collaboration agreements to develop novel treatments for pain and to discover potential treatments for cancer.

10 Feb 2009

Body's defenses may worsen chronic obstructive pulmonary disorder

Although the immune system is designed to protect the body from harm, it may actually worsen one of the most difficult-to-treat respiratory diseases: chronic obstructive pulmonary disorder (COPD), according to new University of Cincinnati (UC) research.

9 Feb 2009

Atorvastatin and lovastatin found to be ineffective for breast cancer prevention

Laboratory work in animals showed limited activity when statins were given to prevent breast cancer, according to a report in the February issue of Cancer Prevention Research , a journal of the American Association for Cancer Research.

8 Feb 2009

Sangamo BioSciences starts trial of CCR5-ZFP therapeutic to treat HIV/AIDS

Sangamo BioSciences, Inc. has announced that its collaborators at the University of Pennsylvania have opened a Phase 1 clinical trial to evaluate SB-728-T for the treatment of HIV/AIDS.

5 Feb 2009

Dry beans reduce risk of mammary cancer

As the world seeks new ways to prevent and treat chronic diseases such as diabetes, heart disease and cancer, more research continues to be conducted on the benefits of certain foods in reducing people's risk of contracting these ailments.

5 Feb 2009

Is rapid transition through menopause linked to earlier onset of heart disease?

An evaluation of 203 women as part of the multifaceted Los Angeles Atherosclerosis Study (LAAS) found that those who transitioned more quickly through menopause were at increased risk for a higher rate of progression of "preclinical atherosclerosis" - narrowing of arteries caused by the thickening of their walls.

29 Jan 2009

Leconotide, an investigative calcium channel blocker, shows potential as pain treatment

Results of a pre-clinical study of leconotide, an investigative calcium channel blocker, shows it has the potential to be safe, selective, and efficacious as a new non-opioid treatment for pain relief. It also holds promise in multiple drug delivery options including nasal spray, transdermal patch, and pills. Data were presented today at the American Academy of Pain Medicine's 25th Annual Meeting.

29 Jan 2009

Medarex announces allowance of IND application for antibody-drug conjugate, MDX-1203

Medarex, Inc. has announced the allowance of an investigational new drug (IND) application filed with the U.S. Food & Drug Administration (FDA) for MDX-1203, the Company's first Antibody-Drug Conjugate (ADC) candidate generated from its proprietary technology.

29 Jan 2009

Stromedix awarded U.S. patent for antibody-based therapeutics

Stromedix, Inc., a biotechnology company focused on innovative therapies for fibrosis and fibrotic organ failure, announced today that the U.S. Patent Office has granted patent number US 7,465,449, which broadly covers monoclonal antibodies to integrin ávâ6, including compositions related to its lead product, STX-100.

23 Jan 2009

Lisofylline drug improves type 2 insulin action; reduces harm of fat in preclinical study

Results of a preclinical study involving DiaKine Therapeutics' lead drug candidate Lisofylline (LSF) indicate the compound may reduce two key risk factors for type 2 diabetes.

23 Jan 2009

Preclinical News and Research

Researchers examine role of high cholesterol in prostate cancer

Statins can stimulate cardiac muscle cell regeneration, improve heart function

Bavarian Nordic updates on breast cancer vaccine studies

Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu

Neuralstem's ALS trial on hold

A stem cell bandage for your knee

Radioimmunotherapy shows promise for HIV infection and viral cancers

New device decreases wait times for patients needing immunotherapy

Trial of Quadramet (153 Samarium-lexidronam) in combo with Velcade shows positive results

FDA approves clinical studies of novel anti-cancer drug developed by Italian researchers

Endo Pharmaceuticals announces research collaborations on novel pain treatments and potential cancer treatments

Body's defenses may worsen chronic obstructive pulmonary disorder

Atorvastatin and lovastatin found to be ineffective for breast cancer prevention

Sangamo BioSciences starts trial of CCR5-ZFP therapeutic to treat HIV/AIDS

Dry beans reduce risk of mammary cancer

Is rapid transition through menopause linked to earlier onset of heart disease?

Leconotide, an investigative calcium channel blocker, shows potential as pain treatment

Medarex announces allowance of IND application for antibody-drug conjugate, MDX-1203

Stromedix awarded U.S. patent for antibody-based therapeutics

Lisofylline drug improves type 2 insulin action; reduces harm of fat in preclinical study

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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