Preclinical Testing News and Research

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A new vaccine shows promise in protecting people from rabies, Lassa fever

A novel vaccine designed to protect people from both Lassa fever and rabies showed promise in preclinical testing, according to new research published in Nature Communications.

12 Oct 2018

Otago scientists make a breakthrough in monkey malaria research

A breakthrough in monkey malaria research by University of Otago scientists encouraged the Bill & Melinda Gates Foundation to fund a special meeting in Dunedin recently.

11 Oct 2018

CIRM approves $1.6M grant to help bring human islet-like organoids to diabetic patients

Approximately 1.25 million Americans are living with type 1 diabetes, with an additional 40,000 people newly diagnosed every year.

27 Sep 2018

Comprehensive analysis reveals weaknesses to target in common pediatric solid tumor

St. Jude Children's Research Hospital investigators have completed the most comprehensive analysis yet of a common pediatric solid tumor, identifying weaknesses to target and a promising precision medicine that is now in clinical trials.

23 Aug 2018

Researchers develop and test new MRI coil for preclinical studies

Researchers from ITMO University developed and tested an MRI coil providing high-resolution imaging of the whole body of a mouse.

9 Aug 2018

Scientists identify drug that could reverse pulmonary arterial hypertension

Scientists at Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago took a major step toward developing a new treatment for pulmonary arterial hypertension, a severe lung disease with a five-year survival rate of 50 percent.

9 Aug 2018

Regenacy Pharmaceuticals partners with CMTA to advance ricolinostat for treating hereditary neuropathy

Regenacy Pharmaceuticals, LLC, a clinical-stage biopharmaceutical company developing breakthrough treatments for diabetic and other peripheral neuropathies, today announced a collaboration with the Charcot-Marie-Tooth Association, a registered non-profit organization serving the hereditary neuropathy patient community, to validate the role of HDAC6 in multiple forms of Charcot-Marie-Tooth disease and evaluate the efficacy of ricolinostat, a selective HDAC6 inhibitor, in animal models.

2 Aug 2018

MODEL-AD Center releases eight new mouse models for Alzheimer's research

The MODEL-AD Center, an ambitious project to develop and distribute precise mouse models of late-onset Alzheimer's disease (AD), has released eight new models carrying genetic mutations found in patients.

23 Jul 2018

NF-κB1 gene known to drive cancer development is critical for preventing stomach cancers

Melbourne researchers have made the surprise discovery that the 'odd one out' in a family of proteins known to drive cancer development is instead critical for preventing stomach cancers.

24 Apr 2018

MIT engineers develop new technology that could improve drug evaluation

MIT engineers have developed new technology that could be used to evaluate new drugs and detect possible side effects before the drugs are tested in humans.

14 Mar 2018

Clinical trial shows safety of promising TSRI stroke drug

A preliminary Phase 2 clinical trial has demonstrated that patients with acute ischemic stroke, the most common type of stroke, can safely tolerate high doses of 3K3A-APC, a promising anti-stroke drug invented at The Scripps Research Institute.

20 Feb 2018

Researchers evaluate potential of stem cells, therapeutic agents in neurodegenerative diseases

As the brain has limited capability for self-repair or regeneration, stem cells may represent the best therapeutic approach for counteracting damage to or degeneration of brain tissue caused by injury, aging, or disease.

24 Oct 2017

Triple-action antibody to be tested as HIV vaccine

Scientists from the National Institutes of Health (NIH) in collaboration with the pharmaceutical company Sanofi have engineered a three-pronged antibody that protected monkeys from two strains of Human Immunodeficiency Virus (HIV) better than the equivalent naturally occurring antibodies.

22 Sep 2017

Simultaneous treatment with anti-PD1 and anti-OX40 cancer therapies may have detrimental effect

Concurrent administration of the T-cell stimulating anti-OX40 antibody and the immune checkpoint inhibitor anti-PD1 antibody attenuated the effect of anti-OX40 and resulted in poor treatment outcomes in mice.

28 Aug 2017

Study may lead to new therapy options for treatment resistant, relapsed endometrial cancer

A team of Cleveland Clinic researchers have discovered a key pathway that leads to recurrence and treatment resistance in endometrial cancer, providing the potential for much needed new therapies for women with limited options.

24 Aug 2017

Novel mussel-inspired glue could one day save lives of youngest patients

Whether to perform surgery on a fetus is a heart-wrenching decision. This type of surgery involves penetrating the highly delicate amniotic sac, increasing health risks to the fetus.

21 Aug 2017

Biologic substance APOSEC shows promise for healing dermal wounds

APOSEC is a substance obtained from white blood corpuscles and was developed by a research group led by thoracic surgeon Hendrik Jan Ankersmit, Head of the Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration at MedUni Vienna.

3 Aug 2017