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Treatment resistance in triple-negative breast cancers linked to softer tissue environment

Researchers at the University of California, San Francisco, have discovered that aggressive, triple-negative breast cancers (TNBCs) can evade treatment by reorganizing and softening the collagen matrix that surrounds the cancer cells.

3 Apr 2021

Exposure to endocrine-disrupting chemicals may increase likelihood of postpartum depression

Endocrine-disrupting chemicals may influence hormonal shifts during pregnancy as well as contribute to postpartum depression, according to a small study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

1 Apr 2021

Taking progestogens during high-risk pregnancy could reduce preterm birth

Taking progestogens - steroid hormones - during pregnancy could reduce the risk of preterm birth in high-risk single baby pregnancies, research has shown.

31 Mar 2021

Stem cell depletion could be an important factor behind miscarriage

Depletion of a certain type of stem cell in the womb lining during pregnancy could be a significant factor behind miscarriage, according to a study released today in STEM CELLS.

27 Mar 2021

YAP inhibitors could facilitate targeted treatment of basal-like breast cancer

Targeted treatment of basal-like breast cancer could be facilitated by YAP inhibitors in the future. As reported by an MDC team headed by Walter Birchmeier in the scientific journal Cancer Research, this type of cancer requires the support of the YAP protein to stimulate the growth of cancer stem cells.

22 Mar 2021

Male fertility and androgen production may be impacted by COVID-19

An interesting new study has appeared online in the journal Hormones that discusses the effects of COVID-19 on the male and female gonads.

22 Mar 2021

Progesterone therapy may improve clinical outcomes for male COVID-19 patients

COVID-19 disproportionately affects men compared with women, raising the possibility that a hormone like progesterone may improve clinical outcomes for certain hospitalized men with the disease.

18 Mar 2021

Study evaluates effectiveness of hormone therapies in managing postmenopausal nocturia

As women age, they are more likely to wake up in the middle of the night to pass urine. The loss of estrogen during the menopause transition accelerates this problem, which is known as nocturia.

17 Mar 2021

High levels of progesterone can reduce stress after concussion, speed recovery in females

Could birth control pills help young female athletes recover faster from concussions and reduce their symptoms?

16 Mar 2021

Unbalanced progesterone may cause preterm or prolonged labor in some pregnant women

New research by the National Institutes of Health found that unbalanced progesterone signals may cause some pregnant women to experience preterm labor or prolonged labor.

11 Mar 2021

Study uncovers mechanism to help explain how maternal stress causes idiopathic preterm birth

Preterm birth is a leading cause of infant deaths and illness in the U.S. -- yet its underlying molecular causes remain largely unclear. About 40 to 50% of preterm births, defined as births before 37 weeks of pregnancy, are estimated to be "idiopathic," meaning they arise from unexplained or spontaneous labor.

9 Mar 2021

Using decision theory for precise choice of breast cancer treatment

The precise choice of treatment for breast cancer depends upon the status of the hormone receptors (for oestrogen and progesterone). Their conventional determination by means of immunohistochemistry (IHC) is associated with a certain error rate, which can be reduced by adding genomic data.

8 Mar 2021

Study illuminates the role of HAND2 gene in timing of human labor

A new study illuminates how a gene called HAND2 may have a hand in the timing of human labor.

22 Feb 2021

Study uses computational framework to identify tamoxifen resistance markers in ER+ breast cancer

One common challenge of cancer therapy is when cancer cells don't respond to a drug that is usually able to kill or weaken them, known as treatment resistance.

26 Jan 2021

Researchers develop a tiny, yet effective method for preventing premature birth

In a study in mice and human cells, Johns Hopkins Medicine researchers say that they have developed a tiny, yet effective method for preventing premature birth.

13 Jan 2021

Understanding traumatic brain injury in women

Analysis from a workshop convened by the National Institute of Neurological Disorders and Stroke (NINDS) in 2017 reveals gaps in and opportunities for research to improve understanding of the effects of traumatic brain injury (TBI) in women.

7 Jan 2021

Surgery may increase length of survival for metastatic breast cancer patients

Surgery, in addition to treatments like chemotherapy and radiation therapy, may increase the length of survival for metastatic breast cancer patients, according to Penn State College of Medicine and Penn State Cancer Institute researchers.

28 Dec 2020

Surgery associated with better survival in metastatic breast cancer patients

22 Dec 2020

New tool aids in the discovery of RNA medicines for undruggable diseases

Imagine trying to throw a bullseye when the dartboard lies buried within a crumpled box. That's the challenge faced by scientists working to make new medicines for some "undruggable" diseases, including a type of metastatic breast cancer.

15 Dec 2020

Combination therapy places no greater burden on early-stage breast cancer patients

Adding an immune checkpoint inhibitor to the standard chemotherapy regimen for patients with early-stage breast cancer places no greater burden on patients' ability to perform day-to-day activities than chemotherapy alone, new research by Dana-Farber/Brigham and Women's Cancer Center investigators shows.

10 Dec 2020