Programmed Cell Death News and Research

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Light-driven bacteria could be used to target and kill cancer cells

Targeting malignant tumors with high precision is challenging for biomedical researchers. However, this scenario is likely to witness a paradigm shift in the near future, through the use of specially engineered bacteria, that can eliminate malignant cells efficiently.

29 Aug 2023

The potential of targeting mitochondria-associated programmed cell death for age-related disease treatment

The review summarized the involvement of mitochondria in age-related disease progression and highlighted its potential as a therapeutic target of these diseases.

28 Aug 2023

UAB researchers show beneficial effect of verapamil for patients with Type 1 diabetes

In 2012, University of Alabama at Birmingham researcher Anath Shalev, M.D., reported that a decades-old blood pressure medication called verapamil completely reversed diabetes in animal models.

25 Aug 2023

New targeted therapy zolbetuximab extends survival for patients with advanced gastric cancer

An international phase 3 clinical trial, done in participation with Weill Cornell Medicine and NewYork-Presbyterian, found that a new targeted treatment called zolbetuximab, given in combination with a standard chemotherapy, extended survival for patients with advanced gastric or gastroesophageal junction cancer that overexpressed a specific biomarker.

23 Aug 2023

New prognostic risk signature for kidney renal clear cell carcinoma identified

Announcing a new publication for Acta Materia Medica journal. Cuproptosis is a newly identified specific form of programmed cell death.

22 Aug 2023

Regulation of cytotoxic T-cell differentiation and exhaustion by mTOR signaling

Researchers describe molecular signalling regulated by mTOR among memory and exhausted cytotoxic CD8+ T lymphocytes.

18 Aug 2023

How conversion between different types of cell death contributes to disease

Researchers elucidate the role of cell death in the pathogenesis of different diseases.

10 Aug 2023

Nutrition meets cancer therapy: How gut microbiome and diet impact immunotherapy success

Researchers investigated the complex relationship between gut bacteria, diet, and patient nutrition.

4 Aug 2023

Phase 1 clinical trial underway to test City of Hope-developed cancer treatment

Researchers at City of Hope, one of the largest cancer research and treatment organizations in the United States, today published a new study explaining how they took a protein once thought to be too challenging for targeted therapy, proliferating cell nuclear antigen (PCNA), and developed a targeted chemotherapy that appears to annihilate all solid tumors in preclinical research.

1 Aug 2023

Tumor-derived GDF-15 suppresses immunotherapy response

Researchers evaluate the impact of tumor-derived GDF-15 on responses to anti-PD-1 immunotherapy.

26 Jul 2023

Pyroptosis: A potential therapeutic target for lung cancer

Lung cancer, one of the most aggressive forms of cancer, continues to be a leading cause of death worldwide. Although several new therapies have been developed for this disease, it has a poor prognosis in its advanced stages.

28 Jun 2023

Circulating cell-free mitochondrial DNA could be useful biomarkers for aging and inflammation

In an eight-year study of more than 600 community-dwelling older adults, Johns Hopkins Medicine researchers say they have further linked levels of cell-free DNA (DNA fragments resulting from cell death) circulating in the blood to chronic inflammation and frailty.

21 Jun 2023

New embryonic cell type that self-destructs to protect the developing fetus discovered

Scientists studying gene activity data of the early human embryo have discovered an overlooked type of cell which self-destructs within days of forming, as part of a quality control process to protect the developing fetus.

20 Jun 2023

Study identifies a promising target for development of vaccine against spotted fever

A protein found in cells of the hard tick Amblyomma sculptum, the main vector of the bacterium that causes Brazilian spotted fever (also known as Rocky Mountain spotted fever), is essential to the tick's survival while feeding, making it a promising target for development of a vaccine, according to an article published in the journal Parasites & Vectors.

7 Jun 2023

Innovative probe could deepen the understanding of key cellular messenger and lead to new drug discoveries

A ground-breaking study by Loughborough University and the University of Oxford has led to the development of a small molecule probe that could deepen our understanding of a crucial cellular messenger and lead to the development of new therapeutic drugs.

5 Jun 2023

Programmed Cell Death News and Research

Light-driven bacteria could be used to target and kill cancer cells

The potential of targeting mitochondria-associated programmed cell death for age-related disease treatment

UAB researchers show beneficial effect of verapamil for patients with Type 1 diabetes

New targeted therapy zolbetuximab extends survival for patients with advanced gastric cancer

New prognostic risk signature for kidney renal clear cell carcinoma identified

Regulation of cytotoxic T-cell differentiation and exhaustion by mTOR signaling

How conversion between different types of cell death contributes to disease

Nutrition meets cancer therapy: How gut microbiome and diet impact immunotherapy success

Phase 1 clinical trial underway to test City of Hope-developed cancer treatment

Tumor-derived GDF-15 suppresses immunotherapy response

Pyroptosis: A potential therapeutic target for lung cancer

Circulating cell-free mitochondrial DNA could be useful biomarkers for aging and inflammation

New embryonic cell type that self-destructs to protect the developing fetus discovered

Study identifies a promising target for development of vaccine against spotted fever

Innovative probe could deepen the understanding of key cellular messenger and lead to new drug discoveries

Researchers characterize a unique molecular mechanism of early stages of programmed cell death

Innovative probe could deepen our understanding of crucial cellular messenger and pave way for new therapeutic drugs

Curcumin can suppress metastasis of colorectal cancer cells by activating a specific signaling pathway

Study explores the role of dynamin protein DYN-1 in regenerative axonal fusion

Mechanism to protect the liver from destruction in case of obesity revealed

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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