Proline News and Research

RSS

UB study reveals a mechanism of gene evolution generating mucin function

From the slime coating slugs to the saliva in our mouths, many slippery bodily fluids contain mucus. So how did this marvel of biology evolve?

26 Aug 2022

SARS-CoV-2 mutational spectra based on reconstructed phylogenetic tree

In a new study, researchers assessed the impact of mutagenesis on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome and the effects of mutations in the neutral regions and non-neutral regions of the genome.

25 Aug 2022

The impact of the P681H spike mutation in the SARS-CoV-2 Alpha variant

Researchers demonstrated the relevance of the P681H spike mutation in the SARS-CoV-2 Alpha variant.

17 Aug 2022

Scientists conduct comparative analysis of monkeypox virus profilin-like proteins and human profilin proteins

In a new study, researchers explored monkeypox virus proteomics and structural characteristics of the A42R protein, the only MPXV protein in the RCSB PDB (protein data bank) and the only profilin-like protein of poxviruses with known structure.

10 Aug 2022

Incorporating a coronavirus antigen into MMR vaccine to produce COVID-19 immunity in kids

New research has advanced COVID-19 vaccine work in several ways: using a modified live attenuated mumps virus for delivery, showing that a more stable coronavirus spike protein stimulates a stronger immune response, and suggesting a dose up the nose has an advantage over a shot.

27 Jul 2022

Researchers identify fusion peptide-specific monoclonal antibodies with broad neutralizing activity

Neutralizing mAbs identified in the current study sheds light on ACE2-triggered conformational change that restricts the immunogenicity of the highly conserved FP region.

14 Jul 2022

Moffitt researchers discover how YAP1 protein contributes to angiogenesis in cancers

The formation of new blood vessels, also known as angiogenesis, is critical to the development and progression of cancer.

8 Jul 2022

A full model of the SARS-CoV-2 spike protein for studying its atomic-level dynamics by multiple microsecond simulations

Researchers constructed a full-length SARS-CoV-2 spike structure in its membrane-bound state to study functionally relevant aspects of its global conformational dynamics.

27 Jun 2022

SARS-CoV-2 variants of concern exhibit divergent interactions with host proteases

In a recent study posted to the bioRxiv* preprint server, researchers at Weill Cornell Medical College assessed the cleavability of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) and related coronaviruses by several proteases of the host.

19 Jun 2022

Scientists characterize type I IFN response during SARS-CoV-2 infection

In a recent study posted to the bioRxiv* preprint server, Canadian researchers assessed the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on interferon (IFN) response.

15 Jun 2022

Cryogenic electron microscopy used to determine the structure of fungal ribosome

Most people carry the fungus Candida albicans on their bodies, without this causing many problems. However, a systemic infection with this fungus is dangerous and difficult to treat.

25 May 2022

SARS-CoV-2 mRNA vaccines do not stimulate interferon stimulatory gene expression in Aicardi Goutières Syndrome patients

A new study aimed to evaluate the immunostimulatory potential of mRNA vaccines in AGS patients.

23 May 2022

Phase 1 trial of COVID-19 PTXCOVID19-B vaccine

A new study demonstrated that the SARS-CoV-2 PTXCOVID19-B vaccine was a promising SARS-CoV-2 vaccine option.

12 May 2022

Changes in gut microbiome impact depression

Over the last five years, the effects of the gut microbiome on depression have gained scientific attention, resulting in a significant increase in research papers.

8 May 2022

Evidence of increased intrinsic cleavability of SARS-CoV-2 Omicron spike protein by host cell furin

Researchers conducted an in vitro analysis to assess the host cell furin-mediated cleavability of the spike protein of the SARS-CoV-2 Omicron (B.1.529) variant.

26 Apr 2022

Mutation-acquiring potential of coronaviruses and efficacies of current COVID-19 vaccines against parent and mutant strains of SARS-CoV-2

Researchers reviewed the antibody resistance exhibited by SARS-CoV-2 variants.

18 Apr 2022

Proline News and Research

UB study reveals a mechanism of gene evolution generating mucin function

SARS-CoV-2 mutational spectra based on reconstructed phylogenetic tree

The impact of the P681H spike mutation in the SARS-CoV-2 Alpha variant

Scientists conduct comparative analysis of monkeypox virus profilin-like proteins and human profilin proteins

Incorporating a coronavirus antigen into MMR vaccine to produce COVID-19 immunity in kids

Researchers identify fusion peptide-specific monoclonal antibodies with broad neutralizing activity

Moffitt researchers discover how YAP1 protein contributes to angiogenesis in cancers

A full model of the SARS-CoV-2 spike protein for studying its atomic-level dynamics by multiple microsecond simulations

SARS-CoV-2 variants of concern exhibit divergent interactions with host proteases

Scientists characterize type I IFN response during SARS-CoV-2 infection

Cryogenic electron microscopy used to determine the structure of fungal ribosome

SARS-CoV-2 mRNA vaccines do not stimulate interferon stimulatory gene expression in Aicardi Goutières Syndrome patients

Phase 1 trial of COVID-19 PTXCOVID19-B vaccine

Changes in gut microbiome impact depression

Evidence of increased intrinsic cleavability of SARS-CoV-2 Omicron spike protein by host cell furin

Mutation-acquiring potential of coronaviruses and efficacies of current COVID-19 vaccines against parent and mutant strains of SARS-CoV-2

Injection-free dermally delivered subunit vaccine strongly neutralizes SARS-CoV-2 variants

Study shows that the SARS-CoV-2 envelope protein potently restricts HIV-1 infection

Study evaluates receptor-binding domain antibodies for their ability to bind and neutralize Omicron

A circRNA COVID vaccine with potential to neutralize SARS-CoV-2 variants

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Latest News