Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

MKK4 enzyme may prevent arrhythmias linked with cardiac hypertrophy

Scientists have discovered an important enzyme molecule that may prevent fatal cardiac disorders associated with cardiac hypertrophy - the leading cause of sudden cardiac death in young athletes.

25 May 2011

Obesity and diabetes rates continue to rise despite decline in consumption of sweeteners

A comprehensive review of research focusing on the debate between High Fructose Corn Syrup and other sweeteners presented today finds there is no evidence of any significant variation in the way the human body metabolizes HFCS as opposed to standard table sugar, or any difference in impact on risk factors for chronic disease.

25 May 2011

PET scans can help determine patients' response to treatment for HIV-MDR tuberculosis

With the deficiencies in knowledge of tuberculosis-as well as in the practices, programs and strategies used to combat the disease and co-infection with human immunodeficiency virus-the spread of multidrug-resistant tuberculosis poses a major problem for the health care community.

25 May 2011

Elan, Proteostasis create innovative drug discovery initiative for neurodegenerative disorders

Proteostasis Therapeutics and Elan Corporation today announced a strategic business relationship to advance Proteostasis' platform for the discovery and development of disease-modifying, small molecule drugs and diagnostics for the treatment of neurodegenerative disorders such as Parkinson's, Huntington's, multiple sclerosis and amyotrophic lateral sclerosis, and a broad array of dementia-related diseases including Alzheimer's.

25 May 2011

Idera Pharmaceuticals' preclinical data on novel GSO technology presented at TIDES 2011

Idera Pharmaceuticals, Inc. today announced the presentation of preclinical data of its novel gene-silencing oligonucleotide technology including observations that demonstrate GSOs exert gene-silencing activity through a similar cellular pathway as siRNA.

25 May 2011

BPD expands existing bioprocess and scale-up laboratory in Poway, CA

Biologics Process Development Inc., a wholly-owned subsidiary of Viropro, will double the size of its existing bioprocess- and scale-up laboratory in Poway, CA.

25 May 2011

Leukemia protein plays a role in Alzheimer's disease

After decades of studying the pathological process that wipes out large volumes of memory, scientists at The Feinstein Institute for Medical Research discovered a molecule called c-Abl that has a known role in leukemia also has a hand in Alzheimer's disease.

25 May 2011

Baked, broiled fish consumption linked to reduced heart failure risk in postmenopausal women

The risk of developing heart failure was lower for postmenopausal women who frequently ate baked or broiled fish, but higher for those who ate more fried fish, in a study reported in Circulation: Heart Failure, an American Heart Association journal.

25 May 2011

New combination therapy eradicates acute lymphoblastic leukemia in children, older adults

In a significant breakthrough, investigators at Weill Cornell Medical College and the University of California, San Francisco, have been able to overcome resistance of a form of leukemia to targeted therapy, demonstrating complete eradication of the cancer in cell and animal studies.

25 May 2011

Proteros, IP-K partner for structure-based drug discovery services in the field of infectious diseases

Proteros Biostructures GmbH announced today that it has entered into a service agreement with Institut Pasteur Korea (IP-K) under which Proteros will provide structure-based drug discovery services to IP-K.

25 May 2011

Studies consistently confirm health benefits of fruit consumption

What do apples, blueberries and prunes have in common? If you guessed that they are all fruits you would be correct. However, that would only be scratching the surface. The fact is that studies consistently confirm the benefits of eating a variety of fruit daily. These benefits include better blood profiles, increased bone density and a strong defense against obesity.

24 May 2011

Scientists mimic dyskeratosis congenita through study of undifferentiated iPS cells

A rare genetic disease called dyskeratosis congenita, caused by the rapid shortening of telomeres, can be mimicked through the study of undifferentiated induced pluripotent stem cells, according to new findings from the Stanford University School of Medicine.

24 May 2011

3M, Radius collaborate to develop BA058 for treatment of osteoporosis

Radius Health, Inc. and 3M Drug Delivery Systems today announced an agreement to collaborate on the development of a transdermal delivery option of BA058, Radius' novel, proprietary PTHrP analog, for the treatment of osteoporosis.

24 May 2011

Loss of elasticity and protein breakdown cause pelvic organ prolapse

A gynecologist and a molecular biologist at UT Southwestern Medical Center have collaborated to show for the first time that pelvic organ prolapse - a condition in which the uterus, bladder or vagina protrude from the body - is caused by a combination of a loss of elasticity and a breakdown of proteins in the vaginal wall.

24 May 2011

Researchers discover protein switch that can trigger heart failure

Researchers at the Peter Munk Cardiac Centre discovered a protein switch which can trigger a cascade of events leading to heart failure, pointing to a new direction for drug development.

24 May 2011

Research could pave way toward new anti-bacterial treatments

A group of proteins that act as the body's built-in line of defense against invading bacteria use a molecular trick to induce bacteria to destroy themselves, researchers at the Indiana University School of Medicine have determined. The research could point the way toward new anti-bacterial treatments that could take on bacteria that are resistant to antibiotics.

24 May 2011

Researchers replicate progression of inflammatory gene changes of kidney from mild to severe diabetic nephropathy

University of Louisville researchers have replicated the inflammatory gene changes of a human kidney as it progresses from mild to severe diabetic nephropathy, using a mouse model developed by a UofL researcher, according to an article published today in the journal Experimental Nephrology. Diabetic nephropathy is the foremost cause of kidney failure.

24 May 2011

Probiotic bacterial protein could offer new oral therapeutic option for inflammatory bowel disorders

A protein isolated from beneficial bacteria found in yogurt and dairy products could offer a new, oral therapeutic option for inflammatory bowel disorders, suggests a study led by Vanderbilt University Medical Center researcher Fang Yan, M.D., Ph.D.

24 May 2011

Inotuzumab ozogamicin achieves over 50% response rate against acute lymphoblastic leukemia

An antibody packaged with a potent chemotherapy drug to selectively destroy acute lymphoblastic leukemia (ALL) cells eradicated or greatly reduced the disease for 61 percent of 46 patients in a phase II study. It will be presented at the 47th annual meeting of the American Society of Clinical Oncology in Chicago June 3-7.

24 May 2011

Mount Sinai researchers identify protein signaling hyperactivity in human sarcoma cells

Researchers from Mount Sinai School of Medicine have discovered a protein signaling pathway that becomes hyperactivated in human sarcoma cells, suggesting that medications to inhibit this pathway may be effective in the treatment of human sarcomas. The research is published in the current issue of the journal Cancer Cell.

24 May 2011

Protein News and Research

Further Reading

MKK4 enzyme may prevent arrhythmias linked with cardiac hypertrophy

Obesity and diabetes rates continue to rise despite decline in consumption of sweeteners

PET scans can help determine patients' response to treatment for HIV-MDR tuberculosis

Elan, Proteostasis create innovative drug discovery initiative for neurodegenerative disorders

Idera Pharmaceuticals' preclinical data on novel GSO technology presented at TIDES 2011

BPD expands existing bioprocess and scale-up laboratory in Poway, CA

Leukemia protein plays a role in Alzheimer's disease

Baked, broiled fish consumption linked to reduced heart failure risk in postmenopausal women

New combination therapy eradicates acute lymphoblastic leukemia in children, older adults

Proteros, IP-K partner for structure-based drug discovery services in the field of infectious diseases

Studies consistently confirm health benefits of fruit consumption

Scientists mimic dyskeratosis congenita through study of undifferentiated iPS cells

3M, Radius collaborate to develop BA058 for treatment of osteoporosis

Loss of elasticity and protein breakdown cause pelvic organ prolapse

Researchers discover protein switch that can trigger heart failure

Research could pave way toward new anti-bacterial treatments

Researchers replicate progression of inflammatory gene changes of kidney from mild to severe diabetic nephropathy

Probiotic bacterial protein could offer new oral therapeutic option for inflammatory bowel disorders

Inotuzumab ozogamicin achieves over 50% response rate against acute lymphoblastic leukemia

Mount Sinai researchers identify protein signaling hyperactivity in human sarcoma cells

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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