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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Mutation causing light chain amyloidosis identified

Light chain amyloidosis, a deadly protein misfolding disease, is caused by multiple mutations in cells that are intended to protect the body. Instead, the mutations send misfolded bundles of proteins through the bloodstream, potentially destroying the heart, kidneys, liver or other organs. Mayo Clinic researchers have identified one of these mutations and have shown that the molecule's shifting position is as important as its unique shape. The findings appear in the current issue of the journal Structure.

12 May 2010

BioGenes study documents insufficient sensitivity of ELISA-based generic HCP assay

BioGenes GmbH, a supplier of GMP-compliant immunoassays and antibodies, completed a study that documents the insufficient sensitivity of an ELISA-based generic host cell protein assay. The results confirm the observation of several contract manufacturers that generic HCP assays are only of limited use for detection of HCPs during manufacturing processes.

12 May 2010

Biotage extends peptide synthesis research collaboration with University of Copenhagen

Biotage, a leading supplier of tools and technology for medicinal and analytical chemistry, announced an agreement to extend the research collaboration with Professor Knud J. Jensen at the Faculty of Life Sciences, University of Copenhagen, to develop new applications on the Biotage Syro Wave in the field of synthetic peptide and protein chemistry. The collaboration builds on Professor Jensen's previous research in developing novel chemistries for and applications of solid-phase peptide synthesis.

12 May 2010

Response Genetics, GSK sign non-exclusive license agreement for BRAF mutational analysis technology

Response Genetics, Inc., a company focused on the development and sale of molecular diagnostic tests for cancer, today announced it has signed a non-exclusive license agreement with GlaxoSmithKline ("GSK"). Under the terms of the agreement, GSK gains certain rights to Response Genetics' proprietary PCR analysis technology and diagnostic expertise to assess BRAF gene mutations in human tumor samples. Payments will be made to Response Genetics upon achivement of agreed-to milestones.

12 May 2010

OriGene Technologies, ISB to create proteotypic PeptideAtlas and SRM/MRM mass spectrometry standard database

OriGene Technologies, Inc., a leading gene-centric life sciences company, and the Institute for Systems Biology (ISB), announce plans to create a proteotypic PeptideAtlas and develop an SRM/MRM (single reaction monitoring, multiple reaction monitoring) mass spectrometry standard database for 5,000 human proteins. The new collaboration will apply ISB's novel systems biology mass spectrometry expertise to OriGene's large collection of full length human proteins.

12 May 2010

Researchers develop new method for tracing carbon flux

Microbial communities are performing important functions all around us - from the earth in our flowerpots to the human gut. Now researchers have developed a method for studying the metabolic functions of microbial communities in detail.

12 May 2010

Anti-inflammatory drugs help block kidney destruction that occurs with hypertension: Researchers

Anti-inflammatory drugs appear to help block the rapid kidney destruction that can occur with hypertension, Medical College of Georgia researchers report.

12 May 2010

ProBioGen signs contract with Virdante Biopharmaceuticals

ProBioGen AG, a technology and service provider for the development and production of biopharmaceutical drug substances today announced signing a contract with Virdante Biopharmaceuticals, Inc., a US-based biopharmaceutical development company.

12 May 2010

Johns Hopkins Bloomberg School of Public Health awarded Grand Challenges Explorations grant

The Johns Hopkins Bloomberg School of Public Health announced today that it has received a $100,000 Grand Challenges Explorations grant from the Bill & Melinda Gates Foundation. The grant will support an innovative global health research project conducted by Jason Rasgon, PhD, an assistant professor with the Johns Hopkins Malaria Research Institute, and his research to develop an evolution-proof pesticide for eliminating mosquitoes that transmit malaria to humans.

12 May 2010

Adult patients with sickle cell disease may develop cognitive problems: Study

Sickle cell disease may affect brain function in adults who have few or mild complications of the inherited blood disease, according to results of the first study to examine cognitive functioning in adults with sickle cell disease.

12 May 2010

CEVEC, Aragen Bioscience announce strategic license agreement

CEVEC Pharmaceuticals, the developer of a novel human expression system derived from amniocytes, and Aragen Bioscience, Inc., a California based contract research and development organization, announced today the signing of a strategic license agreement. This license enables Aragen Bioscience to offer its clients custom recombinant human cell lines expressing biotherapeutic proteins and antibodies as well as the transient and stable production of preclinical and clinical grade material.

12 May 2010

Compugen discovers CGEN-928 as antibody drug target for treatment of multiple myeloma

Compugen Ltd. announced today the discovery and initial experimental validation of CGEN-928 as a drug target for the treatment of multiple myeloma. In recently completed studies, CGEN-928, a membrane protein which previously had no known function or potential clinical utility, demonstrated broad expression in human multiple myeloma tumor cells, including drug resistant and aggressive primary tumor cell lines.

12 May 2010

New combination therapy may help treat anti-estrogen resistant ER+ breast cancer

A study by researchers from the Georgetown Lombardi Comprehensive Cancer Center at Georgetown University Medical Center (GUMC) identifies a potential new combination therapy to "rescue" treatment sensitivity to fulvestrant in estrogen receptor positive breast cancers.

11 May 2010

SNP biomarker could reduce guesswork associated with prescribing drugs

A tiny gene mutation in human liver cells could one day influence how high or low a dose patients need of about half of the clinically used drugs on the market, new research suggests.

11 May 2010

Progenics Pharmaceuticals reports net loss of $18.6M in first-quarter 2010

Progenics Pharmaceuticals, Inc. today announced its results of operations for the quarter ended March 31, 2010.

11 May 2010

Researchers develop new type of drug to kill non-Hodgkin lymphoma tumor cells

Three researchers who are recipients of a collaborative grant from the Samuel Waxman Cancer Research Foundation have developed a new type of drug designed to kill non-Hodgkin lymphoma tumor cells. The breakthrough could lead to potential non-toxic therapies for cancer patients. The Foundation-funded investigators include Ari Melnick, M.D., of Weill Cornell Medical College, Alexander MacKerell, Ph.D., of the University of Maryland and Gilbert Priv-, Ph.D., of the University of Toronto.

11 May 2010

CrystalGenomics completes European Phase I SAD study of CG400549 antibiotic candidate

CrystalGenomics, Inc., a novel drug R&D company announced today that the Phase I SAD (Single Ascending Dose) study for its novel antibiotic candidate, CG400549, has been successfully completed in Europe.

11 May 2010

Astute Medical completes $26.5 million series B financing

Astute Medical, Inc., a developer of novel, biomarker-based medical diagnostics, today announced completion of a $26.5 million series B financing co-led by Domain Associates and Delphi Ventures. Astute will use the funding to advance research and development aimed at the identification and validation of protein biomarkers with the goal of commercializing high potential diagnostic products.

10 May 2010

MicroStockProfit.com features investment report on ARIAD Pharmaceuticals

MicroStockProfit.com announces an investment report featuring ARIAD Pharmaceuticals Inc.. The report includes financial, comparative and investment analyses, and industry information you need to know to make an educated investment decision.

10 May 2010

AngioDynamics introduces redesigned Centros self-centering chronic hemodialysis access catheter

AngioDynamics announced today it has achieved the national launch of the newly redesigned Centros self-centering, chronic hemodialysis access catheter.

10 May 2010

Protein News and Research

Further Reading

Mutation causing light chain amyloidosis identified

BioGenes study documents insufficient sensitivity of ELISA-based generic HCP assay

Biotage extends peptide synthesis research collaboration with University of Copenhagen

Response Genetics, GSK sign non-exclusive license agreement for BRAF mutational analysis technology

OriGene Technologies, ISB to create proteotypic PeptideAtlas and SRM/MRM mass spectrometry standard database

Researchers develop new method for tracing carbon flux

Anti-inflammatory drugs help block kidney destruction that occurs with hypertension: Researchers

ProBioGen signs contract with Virdante Biopharmaceuticals

Johns Hopkins Bloomberg School of Public Health awarded Grand Challenges Explorations grant

Adult patients with sickle cell disease may develop cognitive problems: Study

CEVEC, Aragen Bioscience announce strategic license agreement

Compugen discovers CGEN-928 as antibody drug target for treatment of multiple myeloma

New combination therapy may help treat anti-estrogen resistant ER+ breast cancer

SNP biomarker could reduce guesswork associated with prescribing drugs

Progenics Pharmaceuticals reports net loss of $18.6M in first-quarter 2010

Researchers develop new type of drug to kill non-Hodgkin lymphoma tumor cells

CrystalGenomics completes European Phase I SAD study of CG400549 antibiotic candidate

Astute Medical completes $26.5 million series B financing

MicroStockProfit.com features investment report on ARIAD Pharmaceuticals

AngioDynamics introduces redesigned Centros self-centering chronic hemodialysis access catheter

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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