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Children born of fathers exposed to nicotine inherit enhanced chemical tolerance, study shows

A father's nicotine use may have a significant impact on children's risk of some diseases. In a study published in the online biomedical sciences journal eLife, Oliver J. Rando, MD, PhD, and colleagues at UMass Medical School, demonstrate that mice born of fathers who are habitually exposed to nicotine inherit enhanced chemical tolerance and drug clearance abilities.

14 Feb 2017

New RNAi treatment safely blocks ocular inflammation in mice

Scientists have developed a new RNA interference therapeutic agent that safely blocked ocular inflammation in mice, potentially making it a new treatment for human uveitis and diabetic retinopathy.

14 Feb 2017

TSRI scientists describe how key molecules in the brain work together to trigger intense anxiety

In a new study, researchers at The Scripps Research Institute have described how two important molecules in the brain work together to trigger intense anxiety.

13 Feb 2017

New study reveals potential drug to combat life-threatening effects of COPD

New research published online in The FASEB Journal reveals a potential drug to combat the life-threatening effects of chronic obstructive pulmonary disease (COPD).

13 Feb 2017

Scientists identify new biomarkers that could guide bowel cancer treatment

Colorectal carcinomas arise in different forms, so all treatments do not work for all patients. OncoTrack, a public-private consortium supported by the Innovative Medicines Initiative Joint Undertaking, has conducted one of Europe's largest collaborative academic-industry research projects to develop and assess novel approaches for identification of new markers for colon cancer.

13 Feb 2017

New discovery could lead to more effective malaria vaccine

A team at the Wellcome Trust Sanger Institute has discovered how a promising malarial vaccine target - the protein RH5 - helps parasites to invade human red blood cells.

11 Feb 2017

Malaria mosquitoes exhibit similar sensitivity to heat and horseradish

Researchers at Lund University in Sweden have taken an important step on the road to understanding the underlying mechanism of how and why animals can feel pain in connection with cold or heat. However, according to the study, temperature is just one triggering factor – horseradish, mustard, cinnamon and wasabi have a similar effect.

10 Feb 2017

Scientists identify gene variants that predispose children to developing Kawasaki disease

Kawasaki disease (KD) is the most common acquired heart disease in children. Untreated, roughly one-quarter of children with KD develop coronary artery aneurysms -- balloon-like bulges of heart vessels -- that may ultimately result in heart attacks, congestive heart failure or sudden death.

9 Feb 2017

Noradrenaline exerts positive effects on vision by binding to b-adrenergic receptors

Noradrenaline is a neuromodulator secreted in the brain depending on behavioral context and physiological states of animal, influencing a wide range of physiological functions by modulating brain activity.

9 Feb 2017

Researchers discover function of olfactory receptors in human heart muscle

Researchers have for the first time identified the function of olfactory receptors in the human heart muscle, such as are also present in the nose. One of the receptors reacts to fatty acids that occur in the blood, in patients with diabetes significantly above the normal range.

8 Feb 2017

Study finds link between breast density and contralateral breast cancer

Breast cancer patients with dense breast tissue have almost a two-fold increased risk of developing disease in the contralateral breast, according to new research from The University of Texas MD Anderson Cancer.

8 Feb 2017

Neuroscientists clarify role of controversial immune system protein in Alzheimer's disease

Leading neuroscientists have clarified the role of a controversial immune system protein in Alzheimer's disease, showing it has opposing effects in early and late stages of the disease.

7 Feb 2017

Researchers identify ion channel required for proper regulation of basal metabolism and body weight

UT Southwestern Medical Center researchers have identified an ion channel required for brain cells to suppress eating behavior in response to the hormone leptin or to the anti-obesity drug lorcaserin.

7 Feb 2017

Scientists show how immune receptor activated by bacteria contributes to diabetic bladder dysfunction

Bladder dysfunction is a reality for about half of patients with diabetes and now scientists have evidence that an immune system receptor that's more typically activated by bacteria is a major contributor.

7 Feb 2017

Scientists identify structure of androgenic receptor essential to fight against prostate cancer

A team led by researchers of the Institute of Biomedicine of the University of Barcelona and the Research Institute of the Hospital de la Santa Creu i Sant Paushows for the first time, the three-dimensional structure of the homodimeric androgen receptor ligand-binding domain, a structure that eluded researchers for years.

6 Feb 2017

Study finds under and misuse of adjuvant endocrine therapy for breast cancer patients

A nationwide cancer registry of almost one million patients treated for hormone-sensitive breast cancer shows that one out of six women who should have received post-surgical treatment known as adjuvant endocrine therapy (AET) did not get this recommended component of care.

3 Feb 2017

Sleep helps recalibrate brain cells responsible for learning and memory, mice study shows

Studying mice, scientists at Johns Hopkins have fortified evidence that a key purpose of sleep is to recalibrate the brain cells responsible for learning and memory so the animals can "solidify" lessons learned and use them when they awaken -- in the case of nocturnal mice, the next evening.

3 Feb 2017

New PET radiotracer effectively detects early and advanced stages of prostate cancer

In the featured article from the February 2017 issue of the Journal of Nuclear Medicine, researchers document the first-in-human application of a new imaging agent to help find prostate cancer in both early and advanced stages and plan treatment.

1 Feb 2017

‘Love hormone’ from insects could be used as drug lead to prevent uterine contractility in preterm labour

In a recent study published in "Scientific Reports", an international team of researchers led by MedUni Vienna report that an oxytocin-like neuropeptide ("inotocin") exhibited a specific pharmacological profile for the human receptors of oxytocin (known as the "love hormone") and vasopressin.

1 Feb 2017

Researchers reveal how soy consumption impacts common breast cancer treatment

Georgetown Lombardi Comprehensive Cancer Center researchers have used animal models to reveal new information about the impact - positive and negative - that soy consumption could have on a common breast cancer treatment.

1 Feb 2017

Receptor News and Research

Children born of fathers exposed to nicotine inherit enhanced chemical tolerance, study shows

New RNAi treatment safely blocks ocular inflammation in mice

TSRI scientists describe how key molecules in the brain work together to trigger intense anxiety

New study reveals potential drug to combat life-threatening effects of COPD

Scientists identify new biomarkers that could guide bowel cancer treatment

New discovery could lead to more effective malaria vaccine

Malaria mosquitoes exhibit similar sensitivity to heat and horseradish

Scientists identify gene variants that predispose children to developing Kawasaki disease

Noradrenaline exerts positive effects on vision by binding to b-adrenergic receptors

Researchers discover function of olfactory receptors in human heart muscle

Study finds link between breast density and contralateral breast cancer

Neuroscientists clarify role of controversial immune system protein in Alzheimer's disease

Researchers identify ion channel required for proper regulation of basal metabolism and body weight

Scientists show how immune receptor activated by bacteria contributes to diabetic bladder dysfunction

Scientists identify structure of androgenic receptor essential to fight against prostate cancer

Study finds under and misuse of adjuvant endocrine therapy for breast cancer patients

Sleep helps recalibrate brain cells responsible for learning and memory, mice study shows

New PET radiotracer effectively detects early and advanced stages of prostate cancer

‘Love hormone’ from insects could be used as drug lead to prevent uterine contractility in preterm labour

Researchers reveal how soy consumption impacts common breast cancer treatment

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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