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TSRI scientists develop new dual-targeting drug candidate for treating diabetes and bone disease

In addition to its more obvious ills, type 2 diabetes is a condition closely associated with bone fractures, increasing the risk of fractures twofold. To make matters worse, certain anti-diabetic drugs further increase this risk, particularly in postmenopausal women, severely limiting their treatment options.

28 Jul 2016

Liquid biopsies hold potential for detecting NSCLC EGFR mutations, predicting cancer recurrence

Three manuscripts published in the recent issue of the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer, explored the versatility of liquid biopsies by identifying EGFR mutations using circulating tumor DNA (ctDNA) in urine and plasma and examining circulating tumor cells (CTCs) in plasma to predict the risk of lung cancer recurrence after surgical resection.

26 Jul 2016

New neuroprotective compounds may prevent development of epilepsy

A team led by Nicolas Bazan, MD, PhD, Boyd Professor and Director of LSU Health New Orleans' Neuroscience Center of Excellence, has developed neuroprotective compounds that may prevent the development of epilepsy.

22 Jul 2016

New imaging tool may help detect presence of androgen receptor in prostate cancer patients

Prostate cancer is one of the most common cancers in men. Tumor growth is critically regulated by the androgen receptor, and treatment strategies to lower androgens, such as testosterone, are a mainstay of clinical treatment.

21 Jul 2016

Adding new monoclonal antibody to chemotherapy improves survival in soft-tissue sarcoma patients

Adding a novel monoclonal antibody therapy to traditional chemotherapy increased median survival by nearly a year in patients with advanced sarcoma, a lethal soft-tissue cancer.

21 Jul 2016

Researchers identify stress mechanism in the brain that appears to act as social switch

Meeting new people can be both stressful and rewarding. Research at the Max Planck Institute of Psychiatry, reported today in Nature Neuroscience, suggests that a molecule involved in regulating stress in the brain may also help determine how willing we are to leave the safety of our social group and strike up new relationships.

21 Jul 2016

Researchers develop antibody with potential therapeutic effects against multiple sclerosis

Inserm Unit U919, directed by Prof. Denis Vivien has developed an antibody with potential therapeutic effects against multiple sclerosis.

20 Jul 2016

Bad diet can affect immune system prior to weight gain, new research shows

Australian researchers have discovered that a bad diet has consequences on your immune system even before you notice an increase in body weight.

19 Jul 2016

Researchers discover how Zika virus travels from pregnant mother to fetus

Zika virus can infect numerous cell types in the human placenta and amniotic sac, according to researchers at UC San Francisco and UC Berkeley who show in a new paper how the virus travels from a pregnant woman to her fetus. They also identify a drug that may be able to block it.

19 Jul 2016

Researchers design inhibitory peptide to unleash defence mechanisms against fungal pathogens

For most people, a simple case of thrush or athlete's foot can be quickly and easily treated using over-the-counter anti-fungal creams and pills.

19 Jul 2016

Scientists capture atomic level snapshots of how key enzyme modifies signaling proteins

Scientists have captured atomic level snapshots showing how one key enzyme modifies a protein involved in turning genes on or off inside cells. Understanding this process-which is particularly important when cells are first taking on specialized identities such as nerve cells, muscle, skin, and so on-helps explain how complex organisms can arise from a finite number of genes.

19 Jul 2016

Scientists capture new images of calcium-shuttling molecule linked to aggressive cancers

Scientists have captured new images of a calcium-shuttling molecule that has been linked to aggressive cancers. The three-dimensional structure could help researchers develop novel therapies and diagnostic tools for diseases that are caused by a malfunction in calcium adsorption.

18 Jul 2016

Duke University study provides new mechanistic understanding of OCD

A single chemical receptor in the brain is responsible for a range of symptoms in mice that are reminiscent of obsessive-compulsive disorder (OCD), according to a Duke University study that appears online in the journal Biological Psychiatry.

17 Jul 2016

New treatment may destroy HIV's last refuge

UK scientists may have found a way to destroy HIV's last refuge. A study by Oxford University has confirmed that a treatment developed by a British company can remove the virus in its chosen hiding place, in laboratory conditions, offering hope of a viable treatment.

15 Jul 2016

Study compares aripiprazole and quetiapine for treatment of schizophrenia

Schizophrenia is a common cause of incapacity and is ranked as the third-most-disabling illness subsequent to dementia and quadriplegia.

15 Jul 2016

Scientists uncover structure of cold virus linked to severe asthma, respiratory infections in children

The atomic structure of an elusive cold virus linked to severe asthma and respiratory infections in children has been solved by a team of researchers at the University of Wisconsin-Madison and Purdue University.

14 Jul 2016

Scientists discover novel genetic mutation linked to osteonecrosis of femoral head

Scientists at the Research Institute of McGill University Health Centre have discovered a new genetic mutation linked to osteonecrosis of the hip, specifically the femoral head - the spherical-shaped mass at the top of the femur.

14 Jul 2016

VIB research reveals new insights into ALS

Research into amyotrophic lateral sclerosis (ALS) conducted by VIB-KU Leuven has led to interesting and unexpected conclusions.

14 Jul 2016

Study finds low rates of baseline BMD testing among older women with breast cancer

Aromatase inhibitors (AIs)—drugs that stop the production of estrogen in women—are standard adjuvant therapy for post-menopausal women with hormone-receptor positive breast cancer.

14 Jul 2016

Study finds evidence that PD-1 antibody may benefit men with metastatic prostate cancer

Restoring tumor-specific immunity is a treatment strategy that works well in melanoma and lung cancer patients. Now a new study out of the OHSU Knight Cancer Institute is reviving hope that the approach also may help men with life-threatening prostate cancer.

14 Jul 2016

Receptor News and Research

TSRI scientists develop new dual-targeting drug candidate for treating diabetes and bone disease

Liquid biopsies hold potential for detecting NSCLC EGFR mutations, predicting cancer recurrence

New neuroprotective compounds may prevent development of epilepsy

New imaging tool may help detect presence of androgen receptor in prostate cancer patients

Adding new monoclonal antibody to chemotherapy improves survival in soft-tissue sarcoma patients

Researchers identify stress mechanism in the brain that appears to act as social switch

Researchers develop antibody with potential therapeutic effects against multiple sclerosis

Bad diet can affect immune system prior to weight gain, new research shows

Researchers discover how Zika virus travels from pregnant mother to fetus

Researchers design inhibitory peptide to unleash defence mechanisms against fungal pathogens

Scientists capture atomic level snapshots of how key enzyme modifies signaling proteins

Scientists capture new images of calcium-shuttling molecule linked to aggressive cancers

Duke University study provides new mechanistic understanding of OCD

New treatment may destroy HIV's last refuge

Study compares aripiprazole and quetiapine for treatment of schizophrenia

Scientists uncover structure of cold virus linked to severe asthma, respiratory infections in children

Scientists discover novel genetic mutation linked to osteonecrosis of femoral head

VIB research reveals new insights into ALS

Study finds low rates of baseline BMD testing among older women with breast cancer

Study finds evidence that PD-1 antibody may benefit men with metastatic prostate cancer

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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