Receptor News and Research

RSS

Whole-genome omics data can improve accuracy of breast cancer survival predictions

Precise predictions of whether a tumor is likely to spread would help clinicians and patients choose the best course of treatment. But current methods fall short of the precision needed.

6 Jul 2016

Researchers use FRET to make activation of AMPA receptors optically visible

Our brain is a high-performance computer. One of the key players in this complex system is the AMPA-type glutamate receptor. It ensures that neurotransmission proceeds at a breakneck pace from cell to cell.

6 Jul 2016

Alnylam reports new results from investigational RNAi therapeutic programs

Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), the leading RNAi therapeutics company, announced today preliminary results from its ongoing Phase 2 open-label extension (OLE) studies with patisiran and revusiran, both investigational RNAi therapeutics targeting transthyretin (TTR) for the treatment of hereditary TTR-mediated amyloidosis (hATTR amyloidosis).

6 Jul 2016

Necitumumab drug shows minor added benefit in patients with metastatic NSCLC

The monoclonal antibody necitumumab has been approved since February 2016 for the treatment of patients with locally advanced or metastatic epidermal growth factor receptor (EGFR) expressing non-small cell lung cancer (NSCLC) who have not received prior chemotherapy for this condition.

5 Jul 2016

Study demonstrates role of leukocyte activation receptor CD69 in development of psoriasis

Scientists at the Centro de Investigaciones Cardiovasculares Carlos III have defined the key role of an immune-system receptor in the development of psoriasis, suggesting that it could serve as a therapeutic target for the control of this disease.

5 Jul 2016

Researchers uncover sensing mechanism of food poisoning bacteria found in shellfish

UT Southwestern Medical Center researchers have uncovered a mechanism that a type of pathogenic bacteria found in shellfish use to sense when they are in the human gut, where they release toxins that cause food poisoning.

5 Jul 2016

New test strip can rapidly, cost-effectively detect disease pathogens

At present, bacteria, fungi or viruses can generally only be detected with certainty by way of elaborate laboratory tests or animal experiments. The food and pharmaceutical industries would like to have faster tests to check their products.

4 Jul 2016

New strategy treats fatal autoimmune disease without outward off-target effects

In a study with potentially major implications for the future treatment of autoimmunity and related conditions, scientists from the Perelman School of Medicine at the University of Pennsylvania have found a way to remove the subset of antibody-making cells that cause an autoimmune disease, without harming the rest of the immune system.

4 Jul 2016

Neoadjuvant endocrine therapy 'a reasonable option' for ER-positive breast cancer

Endocrine therapy should be reconsidered as a potential option in the neoadjuvant setting for localised oestrogen receptor-positive breast cancer, say the authors of a meta-analysis.

1 Jul 2016

Study links proteins involved in cell division to insulin signaling

Proteins that play key roles in the timing of cell division also moonlight in regulating blood sugar levels, UT Southwestern Medical Center researchers have found.

1 Jul 2016

AHR plays role in modulating the body's innate immune response to viral infections

A receptor, first known for its role in mediating the harmful effects of the environmental pollutant dioxin in our body, is now understood to play other important roles in modulating the innate immune response.

1 Jul 2016

Kataegis linked to better prognosis for breast cancer patients

Kataegis is a recently discovered phenomenon in which multiple mutations cluster in a few hotspots in a genome. The anomaly was previously found in some cancers, but it has been unclear what role kataegis plays in tumor development and patient outcomes.

1 Jul 2016

Researchers uncover how dysfunction of brain circuit may contribute to memory loss

Two interconnected brain areas - the hippocampus and the entorhinal cortex - help us to know where we are and to remember it later.

30 Jun 2016

New study may help develop effective medication for severe pain

The nerve cells that transmit pain signals in the body are called nociceptors. When activated they release pro-inflammatory neuropeptides. In order to recognise harmful external influences, nociceptors are equipped with a wide range of receptors.

30 Jun 2016

Appetite hormone CART helps increase insulin secretion, reduce glucagon production

The study shows that the appetite hormone CART not only controls the sensation of satiety, but it also helps increase insulin secretion and decrease glucagon production.

30 Jun 2016

Using NMR to investigate intrinsically disordered proteins: an interview with Dr Isabella Felli

“IDPs” is now a widely used acronym that stands for “intrinsically disordered proteins.” It is the term generally used by the scientific community to refer to a wide variety of proteins that do not have a stable 3D structure and are instead characterized by a high extent of local mobility, disorder and many conformers that are accessible at room temperature.

From Bruker BioSpin - NMR, EPR and Imaging 30 Jun 2016

Researchers examine effect of GluD2 receptor on parallel fibre regeneration

Nerves in the central nervous system of adult mammals do not usually regenerate when injured. The granule cell, a nerve cell located in the cerebellum, is different.

30 Jun 2016

New AAV 3.0 program to create next-generation viral vectors for better treatment of inherited diseases

The Perelman School of Medicine at the University of Pennsylvania has launched a new program, called AAV 3.0, to create new viral vectors to find quicker and better treatments for an array of diseases. James M. Wilson, MD, PhD, a professor of Medicine and director of the Orphan Disease Center, will lead an interdisciplinary team of over 30 scientists to create this new technology platform with support provided by the University of Pennsylvania Health System.

30 Jun 2016

Researchers find main cause of necrotizing enterocolitis-related lung damage in preemies

Johns Hopkins researchers report they have figured out a root cause of the lung damage that occurs in up to 10 percent of premature infants who develop necrotizing enterocolitis, a disorder that damages and kills the lining of the intestine.

29 Jun 2016

Study links dopamine D2 receptor to long-term episodic memory

A European study led by Umea University Professor Lars Nyberg, has shown that the dopamine D2 receptor is linked to the long-term episodic memory, which function often reduces with age and due to dementia.

29 Jun 2016

Receptor News and Research

Whole-genome omics data can improve accuracy of breast cancer survival predictions

Researchers use FRET to make activation of AMPA receptors optically visible

Alnylam reports new results from investigational RNAi therapeutic programs

Necitumumab drug shows minor added benefit in patients with metastatic NSCLC

Study demonstrates role of leukocyte activation receptor CD69 in development of psoriasis

Researchers uncover sensing mechanism of food poisoning bacteria found in shellfish

New test strip can rapidly, cost-effectively detect disease pathogens

New strategy treats fatal autoimmune disease without outward off-target effects

Neoadjuvant endocrine therapy 'a reasonable option' for ER-positive breast cancer

Study links proteins involved in cell division to insulin signaling

AHR plays role in modulating the body's innate immune response to viral infections

Kataegis linked to better prognosis for breast cancer patients

Researchers uncover how dysfunction of brain circuit may contribute to memory loss

New study may help develop effective medication for severe pain

Appetite hormone CART helps increase insulin secretion, reduce glucagon production

Using NMR to investigate intrinsically disordered proteins: an interview with Dr Isabella Felli

Researchers examine effect of GluD2 receptor on parallel fibre regeneration

New AAV 3.0 program to create next-generation viral vectors for better treatment of inherited diseases

Researchers find main cause of necrotizing enterocolitis-related lung damage in preemies

Study links dopamine D2 receptor to long-term episodic memory

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Latest News