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S1P1R variation may cause differential patient responses to fingolimod treatment

Multiple sclerosis (MS) is an autoimmune disorder that results in demyelination of neurons. The FDA-approved drug fingolimod (Gilenya, FTY-720) modulates signaling by the bioactive lipid sphingosine-1-phosphate (S1P), which is linked to MS pathogenesis.

16 Jun 2016

Research suggests gonad as vital player in evolutionary process

A pair of studies led by Indiana University researchers provide new evidence that when it comes to evolution, the testes may play a key role.

16 Jun 2016

Novel imaging technique may assist surgeons to improve visualization of ovarian tumors during surgery

A newly devised tumor-specific fluorescent agent and imaging system guided surgeons in real time to remove additional tumors in ovarian cancer patients that were not visible without fluorescence or could not be felt during surgery.

15 Jun 2016

Blood pressure medications can lower stroke, heart attack risk in patients with end-stage renal disease

Two classes of blood pressure medications, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs), are associated with a 16% lower risk of strokes, heart attacks and death in patients with end-stage renal disease who are undergoing peritoneal dialysis, a new study in the journal, Nephrology Dialysis Transplantation, reports.

15 Jun 2016

Excessive AhR signaling helps explain dioxin-induced abnormal behavioral alterations in mice

Dioxins are environmental pollutants that stay in the body for long periods of time because they can accumulate in fat tissue. They are mainly by-products of combustion and industrial processes.

15 Jun 2016

Liraglutide cardioprotective in high-risk Type 2 diabetes patients

Findings of the LEADER trial show that liraglutide treatment may confer a reduced risk of cardiovascular events in patients with Type 2 diabetes and a high vascular risk.

15 Jun 2016

FDG-PET imaging tracks ability of atezolizumab to bolster immunity against NSCLC

Non-small cell lung cancers have a collective reputation for not responding very well to chemotherapy. Researchers at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) are presenting a means of evaluating an immunotherapy that fights off NSCLC by strengthening a patient's own immune system.

14 Jun 2016

Molecular imaging technique could help optimize radiotherapy dose to combat NETs

Aggressive neuroendocrine cancer is something of a dark horse--a rare, elusive and persevering force linked to discouraging long-term survival rates.

14 Jun 2016

CD36 receptor in nasal sensory neurons may be linked to preference for fatty food

A paper by Brazilian researchers published in the journal Scientific Reports describes a study showing that a subgroup of olfactory neurons in the nasal cavity express a cellular receptor specializing in the transport of lipid molecules.

14 Jun 2016

New receptor discovery could lead to novel mosquito repellents

Major rainfall across most of Texas triggering hordes of mosquitos coupled with seemingly constant mosquito-related Zika virus media reports from around the globe may have set the stage perfectly for what one researcher deems as a very significant discovery in man's war against earth's leading human disease carrier.

14 Jun 2016

Genetic blood test can help predict patient’s respone to neuroendocrine cancer therapy

Malignant neuroendocrine tumors (NETs) are relatively rare, notoriously difficult to treat, and associated with poor long-term survival. According to research presented at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, an investigative blood test could predict how patients will respond to peptide receptor radionuclide therapy (PRRT) before they commit to a course of treatment.

14 Jun 2016

PET imaging can help identify autoimmune inflammation in MS

The triggers of autoimmune inflammation in multiple sclerosis (MS) have eluded scientists for many years, but molecular imaging is bringing researchers closer to identifying them, while providing a means of evaluating next-generation therapies for MS, say researchers introducing a study at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging.

14 Jun 2016

PET/CT imaging technique may provide way to break perpetual cycle of alcohol abuse

Alcoholism is a devastating disorder that too often leads to a perpetual cycle of abuse. An emerging molecular imaging technique may provide a way to break that cycle.

14 Jun 2016

Age no barrier to vorapaxar use in ACS

The protease-activated receptor 1 inhibitor vorapaxar offers the same benefits to older and younger patients with non-ST segment elevation acute coronary syndromes, shows further analysis of the TRACER trial.

14 Jun 2016

Griffith researchers move one step closer to understanding cause of Chronic Fatigue Syndrome

A new finding in the cause of Chronic Fatigue Syndrome has been identified by researchers at Griffith University who say they are getting much closer to a complete understanding of this disabling condition.

13 Jun 2016

Study opens up possibility of developing potential hormone therapies for SSc skin disease

The results of a study presented today at the European League Against Rheumatism Annual Congress showed for the first time a beneficial effect of oestrogens in experimental models of skin fibrosis that are representative of the disease process in systemic sclerosis (SSc).

13 Jun 2016

New research offers more insights into development of Kennedy's disease

Kennedy's disease leads to progressive muscle wastage. It is a condition that affects only men and it appears between 40 and 50 years of age. There is no specific treatment available.

13 Jun 2016

Liraglutide enhances high-dose insulin treatment in Type 2 diabetes

The addition of the glucagon-like peptide 1 receptor agonist liraglutide improves short-term outcomes and treatment satisfaction in patients who have uncontrolled Type 2 diabetes despite high doses of insulin, shows a randomised trial.

12 Jun 2016

Dr. Pinchas Tsukerman earns prestigious Kaye Innovation Award for research on cancer immunotherapy

The importance of the body's immune system in protecting against the creation of cancerous tumors has been known for a long time. But despite the existence of a competent immune system, some individuals develop tumors, in part because tumors have ways to evade destructive immunity or induce immune-suppression.

9 Jun 2016

New mathematical model helps examine metabolism of breast epithelium

Researchers have built a model to investigate the metastasis of cancer by examining the metabolism of breast epithelial cells and look at the role of signaling. This research, published in PLOS Computational Biology, may contribute to the development of cell specific anti-cancer interventions.

8 Jun 2016

Receptor News and Research

S1P1R variation may cause differential patient responses to fingolimod treatment

Research suggests gonad as vital player in evolutionary process

Novel imaging technique may assist surgeons to improve visualization of ovarian tumors during surgery

Blood pressure medications can lower stroke, heart attack risk in patients with end-stage renal disease

Excessive AhR signaling helps explain dioxin-induced abnormal behavioral alterations in mice

Liraglutide cardioprotective in high-risk Type 2 diabetes patients

FDG-PET imaging tracks ability of atezolizumab to bolster immunity against NSCLC

Molecular imaging technique could help optimize radiotherapy dose to combat NETs

CD36 receptor in nasal sensory neurons may be linked to preference for fatty food

New receptor discovery could lead to novel mosquito repellents

Genetic blood test can help predict patient’s respone to neuroendocrine cancer therapy

PET imaging can help identify autoimmune inflammation in MS

PET/CT imaging technique may provide way to break perpetual cycle of alcohol abuse

Age no barrier to vorapaxar use in ACS

Griffith researchers move one step closer to understanding cause of Chronic Fatigue Syndrome

Study opens up possibility of developing potential hormone therapies for SSc skin disease

New research offers more insights into development of Kennedy's disease

Liraglutide enhances high-dose insulin treatment in Type 2 diabetes

Dr. Pinchas Tsukerman earns prestigious Kaye Innovation Award for research on cancer immunotherapy

New mathematical model helps examine metabolism of breast epithelium

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Expanding research and clinical options for children with cancer

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