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Breast-feeding associated with reduced risk of ER/PR-negative breast cancer

Breast-feeding reduces the risk for estrogen receptor-negative and progesterone receptor-negative breast cancer, according to a study conducted at Columbia University's Mailman School of Public Health.

19 Oct 2012

Liver x receptor plays an important role in diabetic nephropathy

Researchers have discovered a new therapeutic target for diabetic nephropathy, the leading cause of kidney failure.

19 Oct 2012

Study explains link between infertility and hyperprolactinaemia

One of the most frequent is the existence of tumours that induce an over-secretion of this hormone. These women present with chronic infertility due to anovulation. Thanks to the work of the Inserm researchers from unit 693 "Steroid receptors: endocrinian and metabolic physiopathology", the intimate mechanism of the hyperprolactinaemia alterations affecting reproduction in mice has been discovered.

19 Oct 2012

Lupus investigators receive LRI's first $1 million research grants

The Lupus Research Institute (LRI) today announced the first $1 million research grants given to lupus investigators by a private research organization.

19 Oct 2012

Researchers identify brain mechanisms that regulate cocaine-seeking behavior

Researchers from the University of Wisconsin-Milwaukee (UWM) have identified mechanisms in the brain responsible for regulating cocaine-seeking behavior, providing an avenue for drug development that could greatly reduce the high relapse rate in cocaine addiction.

19 Oct 2012

SSRI use linked to brain hemorrhage

Use of selective serotonin reuptake inhibitors is associated with an increased risk for brain hemorrhage, particularly intracerebral bleeding, suggest meta-analysis findings.

18 Oct 2012

Genetic clues for responders to heart failure drug identified

Researchers have identified genetic signatures that predict which patients respond to the beta blocker bucindolol.

18 Oct 2012

Hereditary genes responsible for pain severity after motor vehicle collisions

Two studies presented at the ANESTHESIOLOGY 2012 annual meeting found that hereditary genes were responsible for the amount and type of pain experienced after a motor vehicle collision (MVC).

17 Oct 2012

Brain’s biological mechanisms may contribute to diet-related disorders

Studies released today explore the neurological component of dietary disorders, uncovering evidence that the brain's biological mechanisms may contribute to significant public health challenges - obesity, diabetes, binge eating, and the allure of the high-calorie meal. The findings were presented at Neuroscience 2012, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news about brain science and health.

17 Oct 2012

UMass professor receives $1 million LRI grant for lupus research

The Lupus Research Institute (LRI) has named University of Massachusetts Medical School Professor of Medicine Ann Marshak-Rothstein, MD, one of two recipients of the first LRI Distinguished Innovator Awards.

17 Oct 2012

Positive results from PROLOR's Rpeg preclinical toxicology study

PROLOR Biotech, Inc. today announced positive results from a preclinical toxicology study designed to assess the safety and tolerability of PROLOR's proprietary long-acting reversible-pegylation technology.

17 Oct 2012

First report of androgen-dependence of exercise on nerve regeneration

A study by researchers from Emory University and Indiana University found that the beneficial effects daily exercise can have on the regeneration of nerves also require androgens such as testosterone in both males and females. It is the first report of both androgen-dependence of exercise on nerve regeneration and of an androgenic effect of exercise in females.

16 Oct 2012

Enrollment complete in Idera's IMO-3100 Phase 2 trial for psoriasis

Idera Pharmaceuticals today announced that it had completed patient enrollment in its randomized, double-blind, placebo-controlled Phase 2 trial of IMO-3100 in patients with moderate-to-severe plaque psoriasis. IMO-3100 is an antagonist of specific Toll-like Receptors (TLRs) that the Company is developing for the treatment of psoriasis and other autoimmune diseases.

15 Oct 2012

AAPS recognizes top scientists in pharmaceutical sciences

During the Opening Session of the 2012 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, AAPS President David Y. Mitchell, Ph.D., presented the following ground-breaking researchers with awards commemorating their contributions to the pharmaceutical sciences:

15 Oct 2012

Scientists resolve new molecular circuit controlling cellular metabolism

Cancer, diabetes, and excess body weight have one thing in common: they alter cellular metabolism. Scientists from the Max Planck Institute of Immunobiology and Epigenetics in Freiburg and the Medical University of Vienna together with an international research team have jointly resolved a new molecular circuit controlling cellular metabolism.

15 Oct 2012

Downregulated protein could be revascularization target in critical limb ischemia

Levels of calcium-sensor protein, S100A1, are downregulated in patients with critical limb ischemia, say researchers who believe the protein could be a potential therapeutic target to promote revascularization.

12 Oct 2012

Key to eczema’s itch uncovered

An influx of neutrophils that secrete a lipid called leukotriene B4 is responsible for triggering the itching and inflammation of the skin typically seen in patients with eczema, suggest study findings.

12 Oct 2012

Study identifies 21 new gene variants associated with risks of heart disease, metabolic disorders

In the largest-ever genetic study of cholesterol and other blood lipids, an international consortium has identified 21 new gene variants associated with risks of heart disease and metabolic disorders.

12 Oct 2012

Johns Hopkins, Iverson enter licensing agreement for molecular diagnostics

Iverson Genetic Diagnostics, Inc. announced today an exclusive licensing agreement with Johns Hopkins University School of Medicine under which Iverson receives global exclusive commercialization rights for molecular diagnostics that are designed to help physicians to assess cardiovascular risk in men and women and infertility risk in women.

12 Oct 2012

NRG1 gene plays an important role in cannabis dependence

A paper by Shizhong Han and colleagues in the current issue of Biological Psychiatry implicates a new gene in the risk for cannabis dependence. This gene, NRG1, codes for the ErbB4 receptor, a protein implicated in synaptic development and function.

12 Oct 2012