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Potential new treatment for fragile X syndrome

Researchers at Vanderbilt University Medical Center, in collaboration with Seaside Therapeutics in Cambridge, Mass., have achieved a milestone in the development of a potential new treatment for fragile X syndrome, the most common genetic cause of autism.

16 Sep 2011

U of C researchers create new model of obsessive-compulsive disorder

A new model of obsessive-compulsive disorder (OCD) that mirrors both symptoms of the disease and the timing of its treatment in humans has been created by University of Chicago researchers, according to a new study.

16 Sep 2011

OXTR gene associated with optimism, self-esteem and mastery

UCLA life scientists have identified for the first time a particlular gene's link to optimism, self-esteem and "mastery," the belief that one has control over one's own life - three critical psychological resources for coping well with stress and depression.

15 Sep 2011

Enrollment commences in ConjuChem's CJC-1134-PC Phase 2 trial for Type 2 diabetes

ConjuChem, LLC, a biotechnology company dedicated to the discovery of novel therapeutics, today announced it has initiated patient enrollment for its Phase 2 clinical trial of its proprietary GLP-1 receptor agonist drug, CJC-1134-PC, in patients with Type 2 diabetes mellitus who are receiving metformin monotherapy.

15 Sep 2011

Natural S-equol supplement does not increase risk of estrogen-sensitive breast cancer

Consuming the soy germ-based compound Natural S-equol and the supplement SE5-OH containing Natural S-equol did not increase the risk of estrogen-sensitive breast cancer, according to a study in the September issue of the peer-reviewed journal Food and Chemical Toxicology.

14 Sep 2011

Lignans lower risk of death in women with breast cancer

Phytoestrogens are plant compounds which, in the human body, can attach to the receptors for the female sexual hormone estrogen and which are taken in with our daily diet. A number of findings have attributed a cancer protective effect to these plant hormones. At DKFZ, a team headed by Prof. Dr. Jenny Chang-Claude summarized the results of several studies in a meta-analysis last year and showed that a diet rich in phytoestrogens lowers the risk of developing breast cancer after menopause.

14 Sep 2011

UC Berkeley scientists offer treatment hope for patients with tinnitus

Neuroscientists at the University of California, Berkeley, are offering hope to the 10 percent of the population who suffer from tinnitus - a constant, often high-pitched ringing or buzzing in the ears that can be annoying and even maddening, and has no cure.

13 Sep 2011

Sanofi's Lyxumia achieves primary efficacy endpoint in study of patients uncontrolled on metformin

Sanofi announced today that Lyxumia (lixisenatide), a once-daily GLP-1 receptor agonist under development for type 2 diabetes, achieved its primary efficacy endpoint of significant HbA1c reduction vs. placebo in patients uncontrolled on metformin.

12 Sep 2011

Spinifex announces new data from EMA401 pre-clinical study on diabetic neuropathy

Spinifex Pharmaceuticals, an Australian pain drug development company, today announces the presentation of new data from a study of EMA401 in a model of diabetic neuropathy.

12 Sep 2011

Heart attack patients with psoriasis more likely to die from cardiovascular disease

Heart attack patients with psoriasis are 26 per cent more likely to die from cardiovascular disease, or suffer from recurrent heart attacks or strokes, and are 18 per cent more likely to die from all causes than those without the inflammatory skin disease.

12 Sep 2011

USC team produces world's first high-resolution images of α7 neuroreceptor

For the first time, USC scientists have mapped out a neuroreceptor. This scientific breakthrough promises to revolutionize the engineering of drugs used to treat ailments such as Alzheimer's disease and schizophrenia.

12 Sep 2011

Chemical biology researchers to meet at Scientific Oktoberfest in München

The "Scientific Oktoberfest" will be this year's meeting point for some of the internationally most distinguished researchers in the field of Chemical Biology. The so-called "CIPSM Fest of Chemical Biology" will be held from the 15th to the 16th of September in the Department of Chemistry of the Ludwig-Maximilians-Universität (LMU) München.

9 Sep 2011

Bristol-Myers Squibb acquires Amira Pharmaceuticals

Bristol-Myers Squibb Company announced today that it has completed its previously announced acquisition of privately held Amira Pharmaceuticals, Inc., a small-molecule pharmaceutical company focused on the discovery and early development of new drugs to treat inflammatory and fibrotic diseases.

9 Sep 2011

Scientists discover backup circuits in cetuximab-resistant cancer cells

Scientists at Dana-Farber Cancer Institute and colleagues overseas have discovered a pair of backup circuits in cancer cells that enable the cells to dodge the effect of a widely used cancer drug.

8 Sep 2011

Abnormal levels of lysophosphatidic acid can trigger congenital hydrocephalus

Scientists at The Scripps Research Institute have found what may be a major cause of congenital hydrocephalus, one of the most common neurological disorders of childhood that produces mental debilitation and sometimes death in premature and newborn children.

8 Sep 2011

APS sponsors 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels

The American Physiological Society is sponsoring the 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels, being held September 18-22 at the Asilomar Conference Grounds in Pacific Grove, Calif. This scientific conference explores the connection between fluid balance in the body and hypertension, a growing global health concern.

8 Sep 2011

Study: Protein's structural arrangement can change its signaling function

In a joint study, scientists from the California and Florida campuses of The Scripps Research Institute have shown that changes in a protein's structure can change its signaling function and they have pinpointed the precise regions where those changes take place.

8 Sep 2011

Loss of estrogen receptor alpha protein may lead to metabolic syndrome

UCLA researchers demonstrated that loss of a key protein that regulates estrogen and immune activity in the body could lead to aspects of metabolic syndrome, a combination of conditions that can cause Type 2 diabetes, atherosclerosis and cancer. Called estrogen receptor alpha, this protein is critical in regulating immune system activity such as helping cells suppress inflammation and gobble-up debris.

7 Sep 2011

IBCRF awards TGen $50,000 to discover genetic origins of inflammatory breast cancer

The Inflammatory Breast Cancer Research Foundation (IBCRF) has awarded $50,000 to the Translational Genomics Research Institute (TGen) to discover the genetic origins of this rare and most deadly form of breast cancer.

7 Sep 2011

Scientists discover two opposing neuronal regulatory circuits for generation, elimination of fear

Emotional balance is regulated by molecular factors behind stress response. When healthy people are faced with threatening situations, they react with a suitable behavioural response and do not descend into a state of either panic or indifference, as is the case, for example, with patients who suffer from anxiety.

7 Sep 2011

Receptor News and Research

Potential new treatment for fragile X syndrome

U of C researchers create new model of obsessive-compulsive disorder

OXTR gene associated with optimism, self-esteem and mastery

Enrollment commences in ConjuChem's CJC-1134-PC Phase 2 trial for Type 2 diabetes

Natural S-equol supplement does not increase risk of estrogen-sensitive breast cancer

Lignans lower risk of death in women with breast cancer

UC Berkeley scientists offer treatment hope for patients with tinnitus

Sanofi's Lyxumia achieves primary efficacy endpoint in study of patients uncontrolled on metformin

Spinifex announces new data from EMA401 pre-clinical study on diabetic neuropathy

Heart attack patients with psoriasis more likely to die from cardiovascular disease

USC team produces world's first high-resolution images of α7 neuroreceptor

Chemical biology researchers to meet at Scientific Oktoberfest in München

Bristol-Myers Squibb acquires Amira Pharmaceuticals

Scientists discover backup circuits in cetuximab-resistant cancer cells

Abnormal levels of lysophosphatidic acid can trigger congenital hydrocephalus

APS sponsors 7th International Symposium on Aldosterone and the ENaC/Degenerin Family of Ion Channels

Study: Protein's structural arrangement can change its signaling function

Loss of estrogen receptor alpha protein may lead to metabolic syndrome

IBCRF awards TGen $50,000 to discover genetic origins of inflammatory breast cancer

Scientists discover two opposing neuronal regulatory circuits for generation, elimination of fear

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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