Receptor News and Research

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Angina drug nifedipine safe for long-term use

Calcium antagonists such as nifedipine are used to relieve the symptoms of angina, but there have been doubts about their long-term safety. However, ACTION--A Coronary disease Trial Investigating Outcome with Nifedipine GITS--provides new information on the drug's long-term use. GITS (gastrointestinal therapeutic system) modifies the release of the drug to provide stable long-term concentrations of nifedipine in blood.

30 Aug 2004

New study confirms benefits of rimonabant in weight loss

Phase III clinical study comparing placebo to rimonabant, the first agent in a new therapeutic class known as selective cannabinoid type 1 (CB1) blockers, showed that overweight or obese people taking rimonabant 20mg once daily benefited from a significant reduction in their body weight

29 Aug 2004

Phase 1 clinical trial of new anticancer drug from Human Genome Sciences

Human Genome Sciences has begun dosing patients in a Phase 1 clinical trial of HGS-TR2J, a novel agonistic human monoclonal antibody to TRAIL Receptor 2, in patients with advanced solid malignancies.

25 Aug 2004

Blueberries may lower cholesterol

New research from the U.S. Department of Agriculture shows that blueberries may lower cholesterol as effectively as a commercial drug and have the potential for fewer adverse side effects.

23 Aug 2004

Genmab's HuMax-CD4 receives U.S. orphan drug designation

Genmab has announced that HuMax-CD4 for the treatment of Mycosis Fungoides (MF), which constitutes 75% of all Cutaneous T-cell Lymphomas (CTCL), has been designated an orphan drug by the US Food and Drug Administration (FDA). The US prevalence of MF is estimated at 16,000 to 20,000.

23 Aug 2004

Novel disease mechanism underlying rheumatoid arthritis

Investigators at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) have identified a novel disease mechanism underlying rheumatoid arthritis that may open the door to new therapies for this and other debilitating autoimmune disorders.

23 Aug 2004

Genetic mutation link to sudden infant death syndrome

Researchers at Rush University Medical Center, and colleagues at the University of Pittsburgh have identified mutations in genes pertinent to the autonomic nervous system among babies who died of sudden infant death syndrome (SIDS) that might explain why they died.

21 Aug 2004

Zinc plays a crucial role in blindness

Dartmouth Medical School researchers in their quest to find cures for inherited diseases have found that zinc plays a crucial role in blindness in over one million people worldwide.

18 Aug 2004

Newly discovered protein switch may be key to understanding sleep disorders, anxiety, and depression

University of California researchers have found that a newly discovered protein switch which they named neuropeptide S appears to work in the brain to enhance wakefulness and reduce anxiety in laboratory animals. According to Rainer Reinscheid and his colleagues, the protein could help in the understanding of sleep disorders, anxiety, and depression.

18 Aug 2004

New guidelines urge early and long-term treatment with Aldosterone blockade therapy

Patients who have had a recent heart attack with ST-elevation (ST-Elevation Myocardial Infarction, or STEMI), complicated by heart failure should be treated with aldosterone blockers according to new guidelines issued recently by the American College of Cardiology (ACC) and the American Heart Association (AHA).

17 Aug 2004

Drug developers should take a different approach to snake venom and heart medications

With the help of snake venom and sophisticated laboratory testing, scientists believe they've uncovered the reason why a group of new heart medications were doing some patients more harm than good.

17 Aug 2004

Relationship between brain chemical messenger glutamate and schizophrenia traits

Researchers at the NIH's National Institute of Mental Health (NIMH) have identified a relationship between a small section of one gene, the brain chemical messenger glutamate, and a collection of traits known to be associated with schizophrenia.

15 Aug 2004

Receptor for estrogen in ovarian cells has been shown to suppress tumor growth

An important receptor for estrogen in ovarian cells has been shown to suppress tumor growth, according to a new study published in the August 15 issue of the journal Cancer Research.

15 Aug 2004

Gene responsible for management of glutamate is a promising candidate in determining risk for schizophrenia

Researchers at the National Institute of Mental Health have identified a relationship between a small section of one gene, the brain chemical messenger glutamate, and a collection of traits known to be associated with schizophrenia.

11 Aug 2004

New biotech alliance to focus on diseases of nerve injury and pain

NeuroTargets Ltd, a discovery-led biotechnology company ‘spun-out’ from the University of Bristol, has formed an exciting new alliance with BioFocus plc, a world leader in collaborative drug discovery, to focus on diseases of nerve injury and pain.

11 Aug 2004

Scientists have turned procrastinating primates into workaholics by temporarily suppressing a gene in a brain circuit involved in reward learning

Using a new molecular genetic technique, scientists have turned procrastinating primates into workaholics by temporarily suppressing a gene in a brain circuit involved in reward learning. Without the gene, the monkeys lost their sense of balance between reward and the work required to get it, say researchers at the National Institute of Mental Health .

11 Aug 2004

Important for physicians to identify patients at risk for hyperkalemia and implement corresponding measures when using ACE inhibitors

Some patients with hypertension or other cardiovascular diseases should be closely monitored in order to maintain safe potassium levels in the body when prescribed certain medications, counsels a nephrologist at UT Southwestern Medical Center at Dallas.

11 Aug 2004

New direction for research into Sly Syndrome

Findings by a Saint Louis University research team led by the scientist who discovered Sly Syndrome 32 years ago point to a new direction for research into the rare genetic disorder that can cause bone deformities, vision and hearing loss, mental retardation and death in children.

9 Aug 2004

Carb-conscious dieters may be lowering their risk of breast cancer

Carb-conscious dieters may be lowering their risk of breast cancer while they’re shedding pounds, based on the findings of research published in this month’s edition of the journal Cancer Epidemiology, Biomarkers & Prevention.

9 Aug 2004

Many U.S. surgeons are not doing adequate numbers of operations for primary breast cancer to optimize patient survival

The study, published August 9, 2004 in the online edition of CANCER, a peer-reviewed journal of the American Cancer Society, demonstrates that fewer surgeries per year negatively impacted patient standard of care. A free abstract of the study is available at CANCER Online.

9 Aug 2004

Receptor News and Research

Angina drug nifedipine safe for long-term use

New study confirms benefits of rimonabant in weight loss

Phase 1 clinical trial of new anticancer drug from Human Genome Sciences

Blueberries may lower cholesterol

Genmab's HuMax-CD4 receives U.S. orphan drug designation

Novel disease mechanism underlying rheumatoid arthritis

Genetic mutation link to sudden infant death syndrome

Zinc plays a crucial role in blindness

Newly discovered protein switch may be key to understanding sleep disorders, anxiety, and depression

New guidelines urge early and long-term treatment with Aldosterone blockade therapy

Drug developers should take a different approach to snake venom and heart medications

Relationship between brain chemical messenger glutamate and schizophrenia traits

Receptor for estrogen in ovarian cells has been shown to suppress tumor growth

Gene responsible for management of glutamate is a promising candidate in determining risk for schizophrenia

New biotech alliance to focus on diseases of nerve injury and pain

Scientists have turned procrastinating primates into workaholics by temporarily suppressing a gene in a brain circuit involved in reward learning

Important for physicians to identify patients at risk for hyperkalemia and implement corresponding measures when using ACE inhibitors

New direction for research into Sly Syndrome

Carb-conscious dieters may be lowering their risk of breast cancer

Many U.S. surgeons are not doing adequate numbers of operations for primary breast cancer to optimize patient survival

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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