Renin News and Research

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Renin, also known as angiotensinogenase, is an enzyme that participates in the body's renin-angiotensin system (RAS) that mediates extracellular volume (i.e., that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. Thus, it regulates the body's mean arterial blood pressure.

Review of six large-scale clinical trials of aliskiren

Hypertension is a serious condition affecting millions.Currently there are seven classes of drugs used to reduce blood pressure. Aliskiren (Tekturna , Rasilez) is the first of a new class of orally active antihypertensive drugs that works by inhibiting renin.

10 May 2007

Dual renin system blocking drug combo provides additional blood pressure-lowering effects

A combination of two medicines that act against the effects of the enzyme renin are more effective in lowering blood pressure than either of the medicines alone, according to a study presented today at the American College of Cardiology's 56th Annual Scientific Session.

2 Apr 2007

Blood pressure control with Clevidipine

Researchers report that an investigational anti-hypertensive therapy may perform better in controlling blood pressure than standard treatments for patients undergoing heart surgery, during a presentation at the American College of Cardiology's 56th Annual Scientific Session.

30 Mar 2007

Tekturna new hypertension drug - first in a decade

The Food and Drug Administration (FDA) in the United States has given it's approval for the use of a new drug to treat hypertension.

7 Mar 2007

FDA approves Tekturna for the treatment of high blood pressure

The U.S. Food and Drug Administration (FDA) today announced the approval of Tekturna (aliskiren) tablets for the treatment of high blood pressure, or hypertension, which affects an estimated 25 percent of Americans and causes increased risk of stroke, heart attack, kidney failure, heart failure and death.

6 Mar 2007

Thermal injury induced insulin resistance is associated with the renin-angiotensin system

Researchers have found a way to prevent insulin resistance in burn-injured rats, a finding that, while still quite preliminary, could eventually save burn victims' lives and speed their recovery.

6 Apr 2006

Enzyme released by cardiac mast cells during heart attack contributes to arrhythmia

In times of cardiac crisis, mast cells in the heart secrete a powerful enzyme, renin, that indirectly triggers dangerous arrhythmias, according to a team of researchers at the Weill Medical College of Cornell University in New York City.

4 Apr 2006

Genetic variations help predict risk for salt-induced high blood pressure

Researchers led by UVa Health System pathologist Robin Felder, Ph.D., have demonstrated that looking for several variations of genes that control blood pressure can predict the risk for high blood pressure caused by high levels of salt.

23 Feb 2006

Chronic heart failure (CHF) is common, deadly, disabling, costly but fortunately - treatable

During the last ten to 15 years, treatment of CHF has been dramatically improved by pharmacological therapy and devices. Treatment also has become more complicated.

5 Sep 2005

Blood pressure enzyme linked to SARS virus, could help fight diseases that cause lung failure

Researchers in Austria say that an enzyme that regulates blood pressure is also involved in the SARS virus, and the discovery could lead to new ways of treating diseases that cause lung failure.

11 Jul 2005

Hormone Replacement Therapy (HRT) has a beneficial impact on cardiovascular health in hypertensive postmenopausal women

Oral Hormone Replacement Therapy (HRT) seems to have a beneficial impact on cardiovascular health in hypertensive postmenopausal women, researchers reported at the American Society of Hypertension Twentieth Annual Meeting held in San Francisco.

16 May 2005

Short-term use of selective COX-2 inhibitors may be safe for patients with cirrhosis of the liver

Short-term use of selective COX-2 inhibitors may be safe for patients with cirrhosis of the liver, according to a recent study that compared the effects of celecoxib, naproxen, and a placebo on cirrhotic patients in a double-blind randomized controlled study.

22 Feb 2005

Olmesartan improves blood supply to kidneys

How do medications that block the renin-angiotensin system (RAS blockers) work to protect against kidney disease in people with diabetes? At least partly by improving the blood supply to the kidneys, suggests a study in the April Journal of the American Society of Nephrology.

17 Feb 2005

Certain blood pressure drugs may slow the deterioration of Alzheimer's disease

Certain blood pressure drugs may slow the deterioration of Alzheimer's disease, according to a study published in the October 12 issue of Neurology, the scientific journal of the American Academy of Neurology.

11 Oct 2004

65 percent of America’s adults are overweight and 31 percent of adults are obese and at risk for chronic diseases

Government and private sector health experts now estimate that 65 percent of America’s adults are overweight and 31 percent of adults are obese and at risk for chronic diseases such as diabetes and hypertension. The link between obesity and hypertension is well known, but the exact nature of the association between the two disorders remains unclear.

11 Jun 2004

Study has important implications for African Americans who suffer from high blood pressure

A new study has important implications for the millions of African Americans who suffer from high blood pressure. The study, AADVANCE, shows Diovan HCT(R) (valsartan and hydrochlorothiazide) lowers blood pressure in African Americans to aggressive recommended target blood pressure goals as effectively as amlodipine.

20 May 2004

Risk of artery plaques increased by use of HIV drugs

An Italian study has provided evidence that HIV drugs called protease inhibitors may increase the risk of artery "plaques."

15 May 2004

A drug that improves function of retinal blood vessels may be able to reduce the risk of stroke

The small study found that endothelial function is abnormal in eye blood vessels of patients who have early-stage hypertension, but that treatment with an angiotensin-receptor blocker (ARB) drug improves endothelial function. The endothelium is the lining of vessel walls and plays a key role in the vessels’ ability to relax and to constrict.

9 Apr 2004