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What is the association between interferon genes and complement regulatory protein expressions in SARS-CoV-2 infections?

Researchers investigated the expression of complement regulatory proteins (CRPs) in coronavirus disease 2019 (COVID-19) to identify potential dysregulated CRP patterns and investigate whether they contribute to COVID-19 pathogenesis.

13 Oct 2022

Researchers report the first RT-qPCR for simultaneous detection and discrimination of Omicron sub-variants

Researchers developed a RT-qPCR system to identify SARS-CoV-2 Omicron variants of concern.

12 Oct 2022

Antibody response trajectories among solid organ transplant recipients in association with mycophenolate mofetil administration

Researchers explored the trajectory of antibody (Ab) titers after coronavirus disease 2019 (COVID-19) vaccination among solid organ transplant recipients (SOTs) with or without mycophenolate mofetil (MMF), or withdrawn from MMF.

11 Oct 2022

Researchers explore drug-repurposing candidates acting against nucleotide-binding pockets of multiple SARS-CoV-2 proteins

In a new study, researchers pursued direct-acting severe acute respiratory syndrome coronavirus-2 drugs that compete for nucleotide-binding pockets (NBPs) of SARS-CoV-2 proteins.

11 Oct 2022

What is the association of SARS-CoV-2 vaccination with the risk of PASC in patients with SARDs?

Findings of a new study depicted that fully vaccinated patients suffering from systemic autoimmune rheumatic diseases harbor a lower propensity to developing long COVID symptoms compared to SARDs patients who are not fully vaccinated.

11 Oct 2022

The association of BNT16B2b2 mRNA COVID-19 vaccine with thrombocytopenia and pneumonitis: A case report

The case report of a patient who developed pneumonitis and thrombocytopenia concurrently after being administered the COVID-19 vaccine.

11 Oct 2022

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

A new paper reviews current knowledge of RdRp inhibitors that could be developed further to provide broadly effective antivirals against SARS-CoV-2 in particular and CoVs in general.

10 Oct 2022

Chronic liver disease in COVID-19 patients

A recent study summarizes the clinical outcomes of COVID-19 patients with chronic liver disease.

10 Oct 2022

Effect of COVID-19 mRNA vaccination on COVID-19 severity during Omicron BA.4 and BA.5 predominance periods

In a new study, researchers estimated the association of first-generation messenger ribonucleic acid (mRNA) vaccines (BNT162b2, mRNA-1273) with coronavirus disease 2019 (COVID-19)-related medical encounters.

10 Oct 2022

The effect of ORF3c, a SARS-CoV-2 accessory protein, on cellular innate immune responses, autophagy, and lung cell mitochondrial metabolism

Researchers explored the role of the ORF3c, a SARS-CoV-2 accessory protein not so extensively studied as yet.

7 Oct 2022

Neonatal mice-based model established that allows for the transmission of clinical SARS-CoV-2 isolates

Researchers established a neonatal mice model that enabled SARS-CoV-2 transmission.

7 Oct 2022

Study using human and animal-derived cell lines suggests human origin of SARS-CoV-2 Omicron variant

Researchers examined the replicative capacity of seven SARS-CoV-2 isolates in 17 cell lines to understand their phenotypic variations and host range.

7 Oct 2022

COVID‐19 pathology across different tissues

Researchers investigated COVID-19 pathophysiology in multiple tissues, including the lungs, kidneys, heart, and brain, for a deeper understanding of its acute and long‐term symptoms.

7 Oct 2022

Exploring the biomarker profiles in severe COVID-19

In new research, researchers estimated the D-dimer levels and characterized lymphocyte subsets and cytokine profiles in severe coronavirus disease 2019 (COVID-19) patients.

7 Oct 2022

Study suggests an immunological benefit of combining previous natural infection with vaccination against COVID-19 using a combination of different vaccine platforms

Researchers explored SARS-CoV-2-targeted immune responses among COVAC1 participants who received a novel saRNA vaccine followed by the mRNA BNT162b2 vaccine BNT162b2 vaccine, with or without prior COVID-19 history.

7 Oct 2022

The involvement of minor intron-containing gene-encoded proteins in viral infections

Researchers explored the role of the minor intron-containing gene (MIG)-encoded proteins (MIG-Ps) depending on minor spliceosome-MiG excision to be expressed in infections by pathogenic viruses.

6 Oct 2022

Researchers create a clinical scoring system to predict viable viral shedding after COVID-19 infection

A recent study published in the Journal of Clinical Virology developed an individualized scoring system to predict the shedding of viable SARS-CoV-2 from COVID-19 positive patients, which would help to determine personalized isolation strategies.

6 Oct 2022

Intranasal vaccine represents an effective broad-spectrum COVID-19 vaccine strategy

Researchers evaluated the efficacy of dNS1-RBD, a novel intranasal COVID-19 vaccine.

6 Oct 2022

$The immune responses and safety of fractional third-doses of heterologous COVID-19 vaccines after CoronaVac primary series$

The immune responses and safety of fractional third-doses of heterologous COVID-19 vaccines after CoronaVac primary series

Researchers evaluated the vaccine effectiveness of half-doses of AZD1222 or BNT162b2 COVID-19 vaccines as a booster dose following primary series vaccination with CoronaVac.

6 Oct 2022

Three-dimensional in vitro model to reproduce COVID-19-induced endothelial dysfunction

In a new study, researchers developed a three-dimensional (3D) in vitro tissue model to assess the effects of SARS-CoV-2 on the vascular endothelial cells.

5 Oct 2022

Ribonucleic Acid News and Research

What is the association between interferon genes and complement regulatory protein expressions in SARS-CoV-2 infections?

Researchers report the first RT-qPCR for simultaneous detection and discrimination of Omicron sub-variants

Antibody response trajectories among solid organ transplant recipients in association with mycophenolate mofetil administration

Researchers explore drug-repurposing candidates acting against nucleotide-binding pockets of multiple SARS-CoV-2 proteins

What is the association of SARS-CoV-2 vaccination with the risk of PASC in patients with SARDs?

The association of BNT16B2b2 mRNA COVID-19 vaccine with thrombocytopenia and pneumonitis: A case report

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

Chronic liver disease in COVID-19 patients

Effect of COVID-19 mRNA vaccination on COVID-19 severity during Omicron BA.4 and BA.5 predominance periods

The effect of ORF3c, a SARS-CoV-2 accessory protein, on cellular innate immune responses, autophagy, and lung cell mitochondrial metabolism

Neonatal mice-based model established that allows for the transmission of clinical SARS-CoV-2 isolates

Study using human and animal-derived cell lines suggests human origin of SARS-CoV-2 Omicron variant

COVID‐19 pathology across different tissues

Exploring the biomarker profiles in severe COVID-19

Study suggests an immunological benefit of combining previous natural infection with vaccination against COVID-19 using a combination of different vaccine platforms

The involvement of minor intron-containing gene-encoded proteins in viral infections

Researchers create a clinical scoring system to predict viable viral shedding after COVID-19 infection

Intranasal vaccine represents an effective broad-spectrum COVID-19 vaccine strategy

The immune responses and safety of fractional third-doses of heterologous COVID-19 vaccines after CoronaVac primary series

Three-dimensional in vitro model to reproduce COVID-19-induced endothelial dysfunction

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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