Ribosome News and Research

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New versions of old antibiotic offers strategy for overcoming drug resistance

Research led by St. Jude Children's Research Hospital scientists has produced new versions of an old antibiotic that are active against difficult-to-treat tuberculosis; offers new strategy for overcoming drug resistance

28 Jan 2014

Researchers develop potential treatment for atherosclerosis

Researchers at Emory and Georgia Tech have developed a potential treatment for atherosclerosis that targets a master controller of the process.

18 Dec 2013

Ribosomal proteins RPL5, RPL11 play essential role in normal cell proliferation

Researchers from the Laboratory of Cancer Metabolism (LCM) led by George Thomas at the Bellvitge Biomedical Research Institute (IDIBELL), the Catalan Institute of Oncology (ICO) and the Division of Hematology/ Oncology, University of Cincinnati, have shown that loss of either one of two tumor suppressors, ribosomal proteins RPL5 or RPL11, fail to induce cell-cycle arrest, but prevent the proliferation of cells as they have a reduced capacity to synthesize proteins.

12 Dec 2013

Advanced cytotoxins help bacteria survive antibiotics treatment

In spite of the fact that the first antibiotics were discovered almost a century ago, infectious diseases such as tuberculosis, encephalitis and meningitis are still serious diseases for humans in the twenty-first century. The World Health Organization (WHO) estimates that there are more than 8 million new cases of tuberculosis per year on a global scale, and that more than 300,000 of these are due to multidrug-resistant strains that are not only difficult to treat, but are also emerging rapidly in regions such as Eastern Europe.

20 Nov 2013

BUSM researchers capture images of channels that direct proteins to right place in cell membranes

Similar to passengers on an urban transit system, every protein made in the cell has a specific destination and function. Channels in cell membranes help direct these proteins to their appropriate target. Researchers at Boston University School of Medicine and their colleagues have now captured images of these channels as they open to allow proteins to pass through a membrane, while the proteins are being made.

24 Oct 2013

Genetic mutation found to restore translational balance in mice

In a biological quirk that promises to provide researchers with a new approach for studying and potentially treating Fragile X syndrome, scientists at the University of Massachusetts Medical School (UMMS) have shown that knocking out a gene important for messenger RNA (mRNA) translation in neurons restores memory deficits and reduces behavioral symptoms in a mouse model of a prevalent human neurological disease.

21 Oct 2013

Elsevier journals currently offers 3D visualization services to authors and readers

Elsevier, a world-leading provider of scientific, technical and medical information products and services, and Kitware, a worldwide leader in developing advanced visualization technologies, today announced that Elsevier journals offer the opportunity to upload 3D datasets when submitting a paper for publication. This way, once published, readers can interactively explore 3D datasets next to the online article on ScienceDirect.

15 Oct 2013

Research findings may lead to new ways to combat cancer

The way cells divide to form new cells - to support growth, to repair damaged tissues, or simply to maintain our healthy adult functioning - is controlled in previously unsuspected ways UC San Francisco researchers have discovered.

12 Oct 2013

Molecular Templates secures $8.5M series C financing plus $10.6M grant from CPRIT

Molecular Templates, Inc., a biopharmaceutical company focused on the discovery and development of a new class of biologic therapeutics, announced today that it recently secured an $8.5M series C financing led by Excel Venture Management. Santé Ventures, an existing investor, also participated in the round.

9 Oct 2013

Scientists unravel secrets of mechanism that snips our genes

Certain diseases such as cystic fibrosis and muscular dystrophy are linked to genetic mutations that damage the important biological process of rearranging gene sequences in pre-messenger RNA, a procedure called RNA splicing.

27 Sep 2013

Study indicates that RNA translation is dictated by translational hotspots

Protein synthesis in the extensions of nerve cells, called dendrites, underlies long-term memory formation in the brain, among other functions. "Thousands of messenger RNAs reside in dendrites, yet the dynamics of how multiple dendrite messenger RNAs translate into their final proteins remain elusive," says James Eberwine, PhD, professor of Pharmacology, Perelman School of Medicine at the University of Pennsylvania, and co-director of the Penn Genome Frontiers Institute.

27 Sep 2013

Researchers develop computational model to accurately simulate complex twists of RNA

A computational model developed by researchers at Rensselaer Polytechnic Institute is the first to accurately simulate the complex twists of a short sequence of RNA as it folds into a critical hairpin structure known as a "tetraloop."

17 Sep 2013

Enanta Gets Additional $9.2M Toward Biodefense Antibiotic Development

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3 Sep 2013

Scientists prove 50-year-old hypothesis of RNA 'higher-order' structure

When Francis Crick and James Watson discovered the double helical structure of deoxyribonucleic acid (DNA) in 1953, it began a genetic revolution to map, study, and sequence the building blocks of living organisms.

27 Aug 2013

UC Davis graduate discovers how eIF4E protein acts upon cancer-promoting mRNA molecules

Researchers have long known that high levels of a specific protein in human cells are linked to tumor growth - but no one has fully understood how.

21 Aug 2013

Cancer-linked mitosis: an interview with Professor Scott Kern, Johns Hopkins University School of Medicine

Mitosis is the process by which a cell gives rise to two daughter cells. It’s the basis behind the growth of the human body, the renewal of the human body as it ages, and unfortunately, the growth of cancers.

7 Aug 2013

Study proposes novel approach for understanding how genome affects biology of the human body

Recent technological developments in genomics have revealed a large number of genetic influences on common complex diseases, such as diabetes, asthma, cancer or schizophrenia. However, discovering a genetic variant predisposing to a disease is only a first step. To apply this knowledge towards prevention or cure, including tailoring treatment to the patient’s genetic profile –also known as personalized medicine – we need to know how this genetic variant affects health.

1 Aug 2013

Montreal scientists develop novel approach for scanning entire genome

Recent technological developments in genomics have revealed a large number of genetic influences on common complex diseases, such as diabetes, asthma, cancer or schizophrenia. However, discovering a genetic variant predisposing to a disease is only a first step. To apply this knowledge towards prevention or cure, including tailoring treatment to the patient's genetic profile -also known as personalized medicine - we need to know how this genetic variant affects health.

1 Aug 2013

Human gene expression mechanism opens new therapeutic strategies against neurological disease

In a study that could change the way scientists view the process of protein production in humans, University of Chicago researchers have found a single gene that encodes two separate proteins from the same sequence of messenger RNA.

4 Jul 2013

Research shows over 50% of tumors have mutations in p53

Researchers of the Cancer Metabolism group at the Bellvitge Biomedical Research Institute (IDIBELL), Catalan Oncology Institute (ICO) and the Division of Hematology-Oncology of the University of Cincinnati, led by George Thomas, have discovered a role for ribosomal 5S RNA in the formation of a complex that regulates the stability of p53.

4 Jul 2013

Ribosome News and Research

New versions of old antibiotic offers strategy for overcoming drug resistance

Researchers develop potential treatment for atherosclerosis

Ribosomal proteins RPL5, RPL11 play essential role in normal cell proliferation

Advanced cytotoxins help bacteria survive antibiotics treatment

BUSM researchers capture images of channels that direct proteins to right place in cell membranes

Genetic mutation found to restore translational balance in mice

Elsevier journals currently offers 3D visualization services to authors and readers

Research findings may lead to new ways to combat cancer

Molecular Templates secures $8.5M series C financing plus $10.6M grant from CPRIT

Scientists unravel secrets of mechanism that snips our genes

Study indicates that RNA translation is dictated by translational hotspots

Researchers develop computational model to accurately simulate complex twists of RNA

Enanta Gets Additional $9.2M Toward Biodefense Antibiotic Development

Scientists prove 50-year-old hypothesis of RNA 'higher-order' structure

UC Davis graduate discovers how eIF4E protein acts upon cancer-promoting mRNA molecules

Cancer-linked mitosis: an interview with Professor Scott Kern, Johns Hopkins University School of Medicine

Study proposes novel approach for understanding how genome affects biology of the human body

Montreal scientists develop novel approach for scanning entire genome

Human gene expression mechanism opens new therapeutic strategies against neurological disease

Research shows over 50% of tumors have mutations in p53

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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