Ribosome News and Research

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Research provides first evidence for a possible cause of familial ALS

Amyotrophic lateral sclerosis (ALS) is a degenerative disease. The neurons responsible for movement begin to die and muscle control is progressively lost, leading to a fatal outcome.

22 Mar 2024

Unraveling the complex cellular composition of aldosterone-producing adenomas

Researchers from Tokyo Medical and Dental University (TMDU) find that the cells that make up aldosterone-producing adenomas become more transcriptionally active and express higher levels of genes linked to hormone production over intratumoral differentiation.

1 Mar 2024

Breakthrough gene therapy method utilizes bird retrotransposon for safe gene insertion

The recent approval of a CRISPR-Cas9 therapy for sickle cell disease demonstrates that gene editing tools can do a superb job knocking out genes to cure hereditary disease.

20 Feb 2024

Novel synthetic antibiotic effective against drug-resistant bacteria

A new antibiotic created by Harvard researchers overcomes antimicrobial resistance mechanisms that have rendered many modern drugs ineffective and are driving a global public health crisis.

15 Feb 2024

New approach to Parkinson's treatment focuses on stopping toxic protein production

Like the Greek mythological beast with a snake's tail and two ferocious heads, a potential Parkinson's medicine created in the lab of chemist Matthew Disney, Ph.D., is also a type of chimera bearing two heads.

9 Jan 2024

$153,000 grant fuels research on new approaches to inhibit STAT3 and develop novel cancer treatments

With an estimated 1.9 million new cases and more than 600,000 deaths each year, cancer remains the second most common cause of death in the U.S., trailing only heart disease. And while there are more than 200 types of cancer, the abnormal synthesis of a protein known as STAT3 is unique to the majority of tumors.

13 Dec 2023

A step forward in vaccine technology: Exploring the effects of N1-methylpseudouridine in mRNA translation

Researchers explored how the incorporation of N1-methylpseudouridine (1-methylΨ) into mRNAs affects ribosomal frameshifting and the overall fidelity of mRNA translation.

7 Dec 2023

Design modifications offer promise for safer and more effective mRNA therapeutics

Researchers have discovered that misreading of therapeutic mRNAs by the cell's decoding machinery can cause an unintended immune response in the body.

6 Dec 2023

New discovery unveils an additional layer of the CRISPR-Cas antiviral defense system

The recent publication in Science by Mogila, Tamulaitiene et al. represents a continuation of the successful scientific research conducted by Gintautas Tamulaitis' group.

4 Dec 2023

Molecular trap offers hope for ALS treatment

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects neurons in the brain and spinal cord causing loss of muscle control.

16 Nov 2023

Stellaromics secures $25 million in series a funding to advance 3D spatial multi-omic profiling

Stellaromics today announced that the company has raised $25 million in a Series A financing round.

7 Nov 2023

Researchers study how cells adapt to stressful and complex environments

Imagine the life of a yeast cell, floating around the kitchen in a spore that eventually lands on a bowl of grapes. Life is good: food for days, at least until someone notices the rotting fruit and throws them out.

16 Oct 2023

Stress-induced ribosome dysregulation may underlie depression

A group of ribosomal protein genes connects animal models of depression to human patients with major depressive disorder.

10 Oct 2023

Antibiotics can sometimes benefit bacteria

Scientists have found a surprising effect of some antibiotics on certain bacteria – that the drugs can sometimes benefit bacteria, helping them live longer.

25 Sep 2023

Unlocking the secret drivers of deadly pancreatic cancer: New target offers hope for treatment

Researchers identify a super-enhancer-regulated RNA-binding protein cascade that drives the growth of pancreatic ductal adenocarcinoma, a deadly form of pancreatic cancer. The discovery offers a promising new avenue for targeted therapy, potentially sidestepping severe side effects associated with other treatments.

10 Sep 2023

Ribosome News and Research

Research provides first evidence for a possible cause of familial ALS

Unraveling the complex cellular composition of aldosterone-producing adenomas

Breakthrough gene therapy method utilizes bird retrotransposon for safe gene insertion

Novel synthetic antibiotic effective against drug-resistant bacteria

New approach to Parkinson's treatment focuses on stopping toxic protein production

$153,000 grant fuels research on new approaches to inhibit STAT3 and develop novel cancer treatments

A step forward in vaccine technology: Exploring the effects of N1-methylpseudouridine in mRNA translation

Design modifications offer promise for safer and more effective mRNA therapeutics

New discovery unveils an additional layer of the CRISPR-Cas antiviral defense system

Molecular trap offers hope for ALS treatment

Stellaromics secures $25 million in series a funding to advance 3D spatial multi-omic profiling

Researchers study how cells adapt to stressful and complex environments

Stress-induced ribosome dysregulation may underlie depression

Antibiotics can sometimes benefit bacteria

Unlocking the secret drivers of deadly pancreatic cancer: New target offers hope for treatment

Stowers researchers reveal why certain anti-cancer drugs can cause unexpected side effects

Scientists capture first images of ribosome-modifying enzymes in action

How conversion between different types of cell death contributes to disease

Researchers discover how ribosomes regulate protein production

Study suggests anxiety increases the risk of subsequent cognitive progression in non-dementia elderly

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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