SARS CoV 2 News and Research

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Melatonin synthesized in the lungs acts as a barrier against SARS-CoV-2

Melatonin synthesized in the lungs acts as a barrier against SARS-CoV-2, preventing expression of genes that encode proteins in cells such as resident macrophages in the nose and pulmonary alveoli, and epithelial cells lining the alveoli, all of which are entry points for the virus.

28 Jan 2021

Study provides a detailed look at vulnerable sites on SARS-CoV-2

A new study led by scientists at La Jolla Institute for Immunology (LJI) suggests that T cells try to fight SARS-CoV-2 by targeting a broad range of sites on the virus--beyond the key sites on the virus's spike protein.

27 Jan 2021

New tool offers data-driven, precision medicine approach to help scientists better understand COVID-19

It is called PAGER-CoV, and it promises to be an important tool in finding therapies for COVID-19.

27 Jan 2021

Temperature, latitude correlate with COVID-19 cases and mortality rates

With cities around the globe locking down yet again amid soaring COVID-19 numbers, could seasonality be partially to blame? New research from the University of Illinois says yes.

27 Jan 2021

COVID-19 mortality rates higher in pregnant women than in similarly aged individuals

Contracting COVID-19 while pregnant can have deadly consequences for the mother, a new study published today in American Journal of Obstetrics and Gynecology shows.

27 Jan 2021

Biliverdin shields SARS-CoV-2 from host antibody response, study finds

A team of international scientists has recently revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts with two heme metabolites, bilirubin and biliverdin, to escape the antibody-mediated host immune responses.

27 Jan 2021

Anakinra shows therapeutic potential in critically ill COVID-19 patients

A team of international scientists recently conducted an open-level clinical trial to investigate the effects of personalized immunotherapy on critically ill COVID-19 patients.

27 Jan 2021

CDC researchers back U.S. school re-openings but with strict COVID-19 regulations

As the U.S. continues to grapple with surging cases and the complex logistics of mass vaccination, is the country in a position to fully re-open its schools for in-person learning? Researchers at the Centers for Disease Control and Prevention (CDC) think so – notwithstanding a few very important caveats.

27 Jan 2021

Could spironolactone treat COVID-19-related pneumonia and pulmonary fibrosis?

Researchers have described the potential of the drug spironolactone, a potassium-sparing diuretic, and anti-androgen, in preventing or alleviating the severity of COVID-19 pneumonia, and in preventing pulmonary fibrosis.

27 Jan 2021

What do we know about the SARS-CoV-2 vaccines so far?

A new study surveys what we know so far about SARS-CoV-2 vaccine candidates from advanced clinical trials.

27 Jan 2021

Allarity Therapeutics announces plans to test antiviral activity of stenoparib drug

Allarity Therapeutics of Hørsholm, Denmark, today announced plans to further test the antiviral activity of stenoparib, its PARP inhibitor, against SARS-CoV-2 lineage B.1.1.7, also known as Coronavirus Variant B117 (the "British variant"), at the COVID-19 Testing Service Center (CTSC) of Northern Arizona University's Pathogen and Microbiome Institute (PMI), a leading U.S. infectious disease testing center.

27 Jan 2021

New ACR Steering Committee established to guide diagnostic testing during COVID-19 pandemic

The Association for Molecular Pathology (AMP), the premier global, molecular diagnostic professional society, today announced the formation of the AMP COVID Response (ACR) Steering Committee to help coordinate and communicate the organization's continued efforts to guide diagnostic testing during the ongoing COVID-19 pandemic and preparations for future emerging outbreaks.

27 Jan 2021

SARS-CoV-2 spike may impair antigen presentation by CD8 T cells

A new study published on the bioRxiv preprint server aims to identify specific viral epitopes on the spike protein from various regions of the spike protein and the T cell responses they evoke.

27 Jan 2021

Rapid transmission of N501Y variants may be due to favorable effects on host receptor binding

Now, in new research posted to the preprint server bioRxiv*, scientists use an experimental structure of the Spike RBD domain co-crystallized with part of the ACE2 receptor and several in silico methods to analyze the possible impacts of three amino acid replacements (Spike K417N, E484K, N501Y) concerning ACE2 binding.

27 Jan 2021

Remdesivir disrupts SARS-CoV-2 more effectively than other similar drugs

In the treatment of SARS-CoV-2, the virus that causes COVID-19, antiviral drug remdesivir has emerged as a promising candidate.

26 Jan 2021

Pain-free microneedle patch can capture biomarkers from interstitial fluid

Blood draws are no fun. They hurt. Veins can burst, or even roll -; like they're trying to avoid the needle too, Oftentimes, doctors use blood samples to check for biomarkers of disease: antibodies that signal a viral or bacterial infection, such as SARS-CoV-2, the virus responsible for COVID-19, or cytokines indicative of inflammation seen in conditions such as rheumatoid arthritis and sepsis.

26 Jan 2021

Mutations in the SARS-CoV-2 receptor-binding domain analyzed

Using more than 100,000 virus genome sequences uploaded in the GISAID database, researchers found around 9,000 mutations in the virus spike protein RBD.

26 Jan 2021

Rapid reopening crucial in promoting the second wave of COVID-19

The spread of the coronavirus disease 2019 (COVID-19) has affected almost a hundred million people, with over two million deaths being attributed to this illness over the past 12 months or so. The only means to counter this so far has been through non-pharmaceutical interventions (NPIs).

26 Jan 2021

Antibodies and inflammatory markers may help identify COVID-19 cases and predict severity

A new preprint appearing on the medRxiv server describes the changes that occur in numerous antibodies and inflammatory molecules with age and at varying stages, or severity, of the infection and resulting illness. The results may help to predict the risk in individual cases.

26 Jan 2021

Elevated levels of certain immune cells in the blood linked to COVID-19 severity

Individual variations in how the immune system responds to SARS-CoV-2 appear to impact the severity of disease.

26 Jan 2021

SARS CoV 2 News and Research

Melatonin synthesized in the lungs acts as a barrier against SARS-CoV-2

Study provides a detailed look at vulnerable sites on SARS-CoV-2

New tool offers data-driven, precision medicine approach to help scientists better understand COVID-19

Temperature, latitude correlate with COVID-19 cases and mortality rates

COVID-19 mortality rates higher in pregnant women than in similarly aged individuals

Biliverdin shields SARS-CoV-2 from host antibody response, study finds

Anakinra shows therapeutic potential in critically ill COVID-19 patients

CDC researchers back U.S. school re-openings but with strict COVID-19 regulations

Could spironolactone treat COVID-19-related pneumonia and pulmonary fibrosis?

What do we know about the SARS-CoV-2 vaccines so far?

Allarity Therapeutics announces plans to test antiviral activity of stenoparib drug

New ACR Steering Committee established to guide diagnostic testing during COVID-19 pandemic

SARS-CoV-2 spike may impair antigen presentation by CD8 T cells

Rapid transmission of N501Y variants may be due to favorable effects on host receptor binding

Remdesivir disrupts SARS-CoV-2 more effectively than other similar drugs

Pain-free microneedle patch can capture biomarkers from interstitial fluid

Mutations in the SARS-CoV-2 receptor-binding domain analyzed

Rapid reopening crucial in promoting the second wave of COVID-19

Antibodies and inflammatory markers may help identify COVID-19 cases and predict severity

Elevated levels of certain immune cells in the blood linked to COVID-19 severity

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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