Sarcopenia News and Research

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PsiOxus completes enrollment in MT-102 Phase II trial on cancer cachexia

PsiOxus Therapeutics, Ltd. (PsiOxus), a development stage biotechnology company, has completed patient enrollment for its Phase II clinical trial to study MT-102, a small molecule therapeutic for the treatment of cancer cachexia.

4 Mar 2013

New review examines role of nutrition in sarcopenia

Sarcopenia, or the gradual loss of muscle mass, is a common consequence of ageing, and poses a significant risk factor for disability in older adults. As muscle strength plays an important role in the tendency to fall, sarcopenia leads to an increased risk of fractures and other injuries.

19 Jan 2013

Physical performance capabilities across the lifespan

Physical performance capabilities, which decline across the lifespan, are strongly associated with daily levels of physical activity. The decrease in physical activity across the lifespan has consequences for health and well-being.

16 Nov 2012

PsiOxus receives UK government grant to initiate ColoAd1 Phase I/II trial for ovarian cancer

PsiOxus Therapeutics, Ltd., a development stage biotechnology company, today announced the award of a £1.7 million ($2.7 million) grant from the UK government-backed Biomedical Catalyst to initiate a Phase I/II clinical trial to assess the use of ColoAd1 in the treatment of platinum-resistant, recurrent ovarian cancer.

5 Nov 2012

Ceramide might play a leading role in muscle deterioration in older adults

As men and women age, increasing quantities of fat tissue inevitably take up residence in skeletal muscle. A small study of older and younger men conducted at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University suggests that a build-up of a fat molecule known as ceramide might play a leading role in muscle deterioration in older adults.

1 Nov 2012

PsiOxus initiates ColoAd1 phase I/II trial in metastatic solid tumours

PsiOxus Therapeutics, Ltd. has treated the first patient in its phase I/II clinical trial of ColoAd1for the treatment of metastatic solid tumours.

26 Sep 2012

Cardiac benefit of exercise proves better late than never

Even individuals who start exercising for 2.5 hours per week in their late 40s and 50s have better cardiovascular health than those who do not adhere to an exercise regimen, say researchers.

15 Aug 2012

Researchers identify myostatin as potential therapeutic target for muscular disorders

The study of muscular system protein myostatin has been of great interest to researchers as a potential therapeutic target for people with muscular disorders. Although much is known about how myostatin affects muscle growth, there has been disagreement about what types of muscle cells it acts upon. New research from a team including Carnegie's Chen-Ming Fan and Christoph Lepper narrows down the field to one likely type of cell.

7 Aug 2012

Osteoporosis and sarcopenia: researchers at UMKC receive $8.3 million to study relationship

The University of Missouri-Kansas City has received a five-year, $8.3 million grant from the National Institute on Aging, part of the National Institutes of Health, to study the relationship between osteoporosis (loss of bone density) and sarcopenia (loss of muscle mass) as people age.

16 Jul 2012

PsiOxus closes Series B round of equity financing

PsiOxus Therapeutics, Ltd. announced that it has closed a Series B round of equity financing totaling £22 million ($34 million).

9 Jul 2012

Scripps Florida scientist to develop new tests for aging and stress-associated diseases

A scientist from the Florida campus of The Scripps Research Institute has been awarded just over $1 million from the National Institutes of Health to develop a range of new tests that could lead to new treatments for a number of stress-associated and degenerative disorders of advancing age.

21 Apr 2012

UK researcher receives IOF-Servier Young Investigator Research Grant

The IOF-Servier Young Investigator Research Grant has been awarded to Dr Mark Edwards, clinical research fellow at the MRC Lifecourse Epidemiology Unit at Southhampton General Hospital in the UK.

27 Mar 2012

Cancer-related fatigue linked to muscle mass and strength

Many patients with advanced cancer suffer from cachexia, a condition also called body-wasting or wasting syndrome, which causes significant weight loss, extreme fatigue and reduces quality of life.

10 Feb 2012

Three-step strategy for healthy bones and strong muscles

For this year's World Osteoporosis Day, the International Osteoporosis Foundation (IOF) is releasing a 24-page report promoting a three-step strategy for healthy bones and strong muscles.

14 Oct 2011

Patients with sarcopenia more likely to have worse outcomes from melanoma

It's not how old but how frail patients are that can predict how well they will fare after a melanoma diagnosis. In fact, young patients in poor health may have worse outcomes than older patients in good shape.

31 Aug 2011

Researchers discover biological mechanism behind sarcopenia

Researchers at Columbia University Medical Center have discovered the biological mechanism behind age-related loss of muscle strength and identified a drug that may help reverse this process.

3 Aug 2011

Muscle mass may influence risk for diabetes: Study

According to a new study greater muscle mass may reduce the odds of developing diabetes. There have been studies that show having less body fat reduces diabetes risk and that exercise can help too, but the new study by UCLA scientists suggests a link between higher muscle mass and a lower risk of diabetes.

29 Jul 2011

Dietary protein reduces hunger and increases fullness in obese men

A new study demonstrates that higher-protein meals improve perceived appetite and satiety in overweight and obese men during weight loss. According to the research, published in Obesity, higher-protein intake led to greater satiety throughout the day as well as reductions in both late-night and morning appetite compared to a normal protein diet.

11 Jul 2011

Dairy Council of California co-hosts June 12 symposium at IFT's food expo

From body builders to baby boomers, more Americans are consuming higher-protein diets for benefits including muscle building and maintenance in later life, satiety, weight loss and more.

10 Jun 2011

Losartan therapy improves muscle injury regeneration and prevents disuse atrophy

Using geriatric mice, a Johns Hopkins research team has shown that losartan, a commonly used blood pressure drug, not only improves regeneration of injured muscle but also protects against its wasting away from inactivity.

12 May 2011