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Metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 Delta, Alpha, and Omicron variants

Researchers examined how SARS-CoV-2 variants of concern differentially use an additional metalloproteinase-dependent entry pathway to enter the host cells.

24 Feb 2022

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

The role played by the host enzyme TMPRSS2 in infection and cancer is the focus of a new study.

23 Feb 2022

hAELVi cell infection model mimics SARS-CoV-2 Omicron infection in lower respiratory tract of humans

In a recent study posted to the Research Square* preprint server, which is under consideration at Scientific Reports, a team of researchers developed a novel human Alveolar Epithelial Lentivirus immortalized (hAELVi) cell infection model to estimate the replication potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory viruses in the lower respiratory tract of humans.

23 Feb 2022

Surfactant-containing oral mouthwashes target the lipid envelope of SARS-CoV-2

Researchers demonstrated the composition and importance of SARS-CoV-2 lipid envelope and assessed the antiviral potential of oral mouthwashes targeting these lipid envelopes.

21 Feb 2022

Study suggests non-classical inhibition of TBK1/IKKε is protective against severe COVID-19 immunopathology in vivo

A study posted suggested the inhibition of TBK1 and its homolog KKε could decrease the severity of COVID-19.

21 Feb 2022

Mechanisms of IL-6 expression in peripheral monocyte-derived macrophages infected with SARS-CoV-2

Researchers examined the detailed mechanisms of ‘cytokine storm’ that induces ARDS, often resulting in the death of severely ill COVID-19 patients.

21 Feb 2022

Mechanism of fatty-acid coupled adaptive immunity in SARS-CoV-2 revealed

A new study explains how SARS-CoV-2 adapts its immunogenicity to the immune response of the host.

20 Feb 2022

Impact of several ACE2 coding missense variants and their effect on ACE2 protein subcellular localization and trafficking

Researchers investigated the connecting link between viral genetic variability and clinical heterogeneity of COVID-19 by analyzing the effect of several missense mutations on the ACE2 receptor coding sequence.

18 Feb 2022

Characterization of SARS-CoV-2 variants in unvaccinated and vaccinated U.S. military

Researchers discuss the genomic and virological characterization of SARS-CoV-2 variants among unvaccinated and vaccinated U.S military personnel.

16 Feb 2022

Variations in the neutralization of SARS-CoV-2 variants in vaccinated mice and primates

In a new study, researchers demonstrated the variations in the neutralizing antibody responses induced by SARS-CoV-2 vaccines in humans, non-human primates, and mice against the SARS-CoV-2 variants of concern.

14 Feb 2022

mRNA-1273 and mRNA-1273.529 Omicron-specific boosters highly effective in mouse model

In a study posted to the bioRxiv* preprint server, a team of researchers from the United States evaluated the protective effect of the preclinical version of the current Moderna Omicron-targeted mRNA-1273.529 vaccine against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 Omicron infection in mice.

14 Feb 2022

Testes found to be a viral reservoir for SARS-CoV-2 replication

In a recent study posted to the medRxiv* pre-print server, researchers used a suite of methods to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the testis of patients who died from coronavirus disease 2019 (COVID-19) to gain insights into SARS-CoV-2 tropism inside testis and its impact on male fertility.

13 Feb 2022

Screening assays identify TMPRSS2 inhibitors from drug repurposing candidates useful as COVID-19 therapeutic

Researchers used an assay toolset for discovering new transmembrane protease serine 2 inhibiting drug repurposing candidates, that can be useful as therapeutics for COVID-19 treatment.

10 Feb 2022

How SARS-CoV-2 infection progresses throughout the respiratory system

Researchers discuss the progression of SARS-CoV-2 infection throughout the respiratory epithelium.

9 Feb 2022

Discovery shows promise for development of a new non-hormonal contraceptive

A discovery that blocks the normal transition of semen from a thick gel to a liquid shows promise for development of a new form of non-hormonal, over-the-counter contraception.

7 Feb 2022

Study shows chronic alcohol consumption as a potential risk factor for SARS-CoV-2-infection

In a study posted to the bioRxiv* preprint server, a team of researchers from Germany studied the expression data of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-relevant genes such as angiotensin-converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2), and the G-protein coupled receptor Mas in an alcohol-exposed rodent model infected with SARS-CoV-2.

7 Feb 2022

Serine News and Research

Metalloproteinase-dependent entry pathway differentially used by SARS-CoV-2 Delta, Alpha, and Omicron variants

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

hAELVi cell infection model mimics SARS-CoV-2 Omicron infection in lower respiratory tract of humans

Surfactant-containing oral mouthwashes target the lipid envelope of SARS-CoV-2

Study suggests non-classical inhibition of TBK1/IKKε is protective against severe COVID-19 immunopathology in vivo

Mechanisms of IL-6 expression in peripheral monocyte-derived macrophages infected with SARS-CoV-2

Mechanism of fatty-acid coupled adaptive immunity in SARS-CoV-2 revealed

Impact of several ACE2 coding missense variants and their effect on ACE2 protein subcellular localization and trafficking

Characterization of SARS-CoV-2 variants in unvaccinated and vaccinated U.S. military

Variations in the neutralization of SARS-CoV-2 variants in vaccinated mice and primates

mRNA-1273 and mRNA-1273.529 Omicron-specific boosters highly effective in mouse model

Testes found to be a viral reservoir for SARS-CoV-2 replication

Screening assays identify TMPRSS2 inhibitors from drug repurposing candidates useful as COVID-19 therapeutic

How SARS-CoV-2 infection progresses throughout the respiratory system

Discovery shows promise for development of a new non-hormonal contraceptive

Study shows chronic alcohol consumption as a potential risk factor for SARS-CoV-2-infection

Investigating the immunology of COVID-19 infected children

Study links COVID-19 inflammatory manifestations in brain lysates to Alzheimer’s Disease markers

Evaluating effects of D614G and P681R/H mutations on SARS-CoV-2 VOCs

SARS-CoV-2 omicron variant shown to replicate less efficiently in human lungs

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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