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Study finds specific direct targets for lung cancer treatment

A team of researchers at the Salk Institute has found two therapeutic targets for the deadly type of lung cancer, non-small-cell lung carcinomas (NSCLCs), which accounts for 85 percent of all lung cancer cases. They believe that the breakthrough discovery could pave the way for the development of new treatments for a majority of lung cancer patients.

29 Jul 2019

Unexpected discovery could improve treatment of cancer, other diseases

EU-funded researchers have discovered an important new mechanism by which cells flag and repair damage to their DNA - an unexpected finding that could improve the treatment of diseases such as cancer.

23 Jul 2019

Study sheds light on complex caspase-1-induced cell death mechanisms

Most unnecessary or dangerous cells such as virus-infected cells commit suicide by activating an in-built suicide program.

5 Jul 2019

Targeted treatment offers symptom relief for patients with psychosis

Treatment for individuals who experience psychosis, such as hallucinations and delusions as a result of a psychiatric illness, can be targeted to a specific structural mutation, according to a study published by researchers from McLean Hospital and other institutions in the journal Biological Psychiatry.

3 Jul 2019

UAB scientists identify new target for drug intervention in Alzheimer's disease

Scientists at the University of Alabama at Birmingham have identified an enzyme in the brain that may be an intriguing target for interventions against Alzheimer's disease and other dementias.

26 Jun 2019

Dietary supplement improves neuronal function of a patient with atypical Rett syndrome

A multicentric translational research study carried out by groups of the Bellvitge Biomedical Research Institute, Sant Joan de Déu Hospital, the University of Barcelona, Hospital Clínic, the University of Vic, Sant Pau i la Santa Creu Hospital, the Rare Diseases Networking Biomedical Research Centre and the Commissariat à l'Énergie Atomique, has demonstrated the potential of the amino acid L-serine - administered as a dietary supplement - to improve the neuronal function of a patient with a mutation of glutamate receptors associated with atypical Rett syndrome with severe encephalopathy.

19 Jun 2019

Scientific discovery may lead to a treatment for lupus

A team of scientists has uncovered the structure of a regulatory complex that is involved in the release of cytokines and can be inhibited to treat lupus.

31 May 2019

Researchers find new molecular targets for fighting autoimmunity

BRCA--the family of DNA-repair proteins associated with breast, ovarian prostate, and pancreatic cancers--interacts with a multipart, molecular complex that is also responsible for regulating the immune system.

30 May 2019

Inhibition of CRMP2 phosphorylation promotes axonal regeneration after optic nerve injury

A new study by Professor Toshio Ohshima of Waseda University has found that the inhibition of phosphorylation of collapsing response mediator protein 2, a microtubule-binding protein, suppresses degeneration of nerve fibers and promotes its regeneration after optic nerve injury.

22 May 2019

Scientists create bacteria with man-made DNA

In a landmark research study, a living organism (E. coli) has been made using entirely human-made DNA.

21 May 2019

Blocking protein-digesting enzyme may help improve metabolic health

Blocking the action of an enzyme involved in protein digestion may improve metabolic health, according to a new study published ahead of print in the American Journal of Physiology--Gastrointestinal and Liver Physiology.

8 May 2019

Synthesizing Modified and Pharmaceutically Relevant Peptides

In this interview, CEM Corporation talks to News-Medical Life Sciences about using their product the Liberty Blue for Automated High-Efficiency Solid Phase Peptides Synthesis of Modified and Pharmaceutically Relevant Peptides.

From CEM Corporation - Life Science 24 Apr 2019

Study offers novel insights into how a major tumor suppressor pathway becomes deactivated

The Hippo pathway is an important biological tumor suppressor program that controls cell growth and organ size in humans.

5 Apr 2019

Scientists cast new light on function of long-mysterious PCSK9 mutation

High levels of low-density lipoproteins, parcels of lipids and protein that carry cholesterol, are a leading risk factor for heart disease. Many cholesterol medications lower LDL, some of them by targeting the protein PCSK9. In the January issue of the Journal of Lipid Research, scientists at the University of California, San Francisco, report on an investigation into why experiments on PCSK9 give different results in a test tube and in liver cells.

2 Jan 2019

Stress related pathway instrumental in controlling function of immune cells

The immune system is composed of a wide range of different immune cells each with dedicated functions. Natural killer T cells form a specialized immune cell that protects against a variety of diseases such as cancer, autoimmunity, metabolic disease or certain infections such as Lyme disease.

20 Dec 2018

UT Southwestern researchers discover enzyme that promotes tumor growth

UT Southwestern researchers have found that an enzyme on the surface of some lung cancer cells helps feed the cancer, making it a tempting treatment target.

28 Nov 2018

D-serine produced by gut microbiota protects against acute kidney injury, show study

The kidney is an organ not only for excreting body waste by urine but also for maintaining body homeostasis in close cooperation with other organs.

27 Nov 2018

New discovery confirms central importance of PINK1-Parkin pathway in Parkinson's patients

Researchers at the Faculty of Medicine, University of Helsinki, make an unexpected and vital contribution to an international collaborative effort in Parkinson's disease research.

7 Nov 2018

Researchers study significance of water in a promising cancer biomarker

The UPV/EHU's Department of Physical Chemistry and the Biofísika Institute have conducted a multidisciplinary study of the Tn antigen that appears in 90% of cancers. Two variants that appear to be similar but which have very different shapes in water have been studied.

26 Oct 2018

The Lancet Infectious Diseases journal publishes clinical trial results for Shionogi’s cefiderocol

Shionogi & Co., Ltd. announced today that The Lancet Infectious Diseases journal has published clinical results from the pivotal randomized controlled trial evaluating cefiderocol for the treatment of complicated urinary tract infection in patients at risk of multidrug-resistant Gram-negative infections.

26 Oct 2018