Severe Acute Respiratory News and Research

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Next-gen intranasal vaccine takes on measles, mumps, and multiple COVID-19 variants in one shot

Researchers developed an intranasal trivalent measles-mumps-SARS-CoV-2 vaccine that provides robust protection against multiple coronavirus variants. Leveraging the established measles-mumps-rubella platform, this vaccine demonstrates broad and adaptable immune responses, especially against Delta and Omicron variants.

8 Oct 2023

Antigenic cartography decodes the mysteries of SARS-CoV-2 variants and vaccines

Using antigenic cartography, researchers analyzed cross-reactivity patterns of SARS-CoV-2 variants and the effect of spike-protein changes on post-infection and vaccination immune responses. The study illuminated unique neutralization profiles and underscored the evolving defense mechanisms with repeated immunizations.

8 Oct 2023

Decoding the twist: Coronavirus spike proteins reveal their intricate invasion dance

Researchers use cryo-EM and molecular dynamics to reveal conformational changes in the spike proteins of human coronavirus HKU1 upon binding with a receptor. Findings unveil the complexity of beta coronavirus attachment, suggesting a more intricate mechanism of host cell invasion than previously understood.

8 Oct 2023

Novavax vaccine shows resilient defense against symptomatic COVID-19 despite Omicron challenge

Recent study assesses NVX-CoV2373 vaccine's effectiveness against Omicron variant. Findings show decreased efficacy over four months, but stable protection against symptomatic COVID-19.

8 Oct 2023

The potential benefits of ribavirin and pleconaril treatment on type 1 diabetes

Researchers investigate whether ribavirin and pleconaril could stimulate endogenous insulin production among individuals with incident type 1 diabetes.

8 Oct 2023

COVID-19's ripple effect: South African TB diagnostics take a hit

COVID-19 disrupts TB diagnostic services in South Africa's primary health clinics, highlighting the need for robust systems resilient to future pandemics.

8 Oct 2023

Nirmatrelvir and ritonavir combo cuts COVID-19 risks for high-vulnerability groups

Nirmatrelvir and ritonavir treatment significantly reduces the risk of hospitalization and death from COVID-19 in high-risk individuals, according to a recent JAMA Network Open study. However, the treatment's efficacy varied based on the degree of vulnerability, emphasizing tailored approaches for different risk groups.

8 Oct 2023

Protein recombinant vaccine NVX-CoV2373 confers protection during Omicron dominant period in Italy

The NVX-CoV2373 COVID-19 vaccine offers significant protection against symptomatic infections, but its effectiveness against SARS-CoV-2 declines within four months, according to a study in JAMA Network Open using Italian data. However, its protection against symptomatic COVID-19 seems to remain stable during this period.

8 Oct 2023

Inhaled nitric oxide shows promise as treatment for COVID-19 respiratory failure

Inhaled nitric oxide gas widens blood vessels in the lungs and is used to treat severe cardio-pulmonary conditions in newborns and adults.

6 Oct 2023

Why are most Americans skipping the COVID-19 booster?

A study in the journal Vaccine reveals that misinformation and concerns about side effects are leading reasons why over 80% of eligible Americans have skipped the SARS-CoV-2 vaccine booster. The research underscores the need for more public education about the vaccine's benefits in combating severe COVID-19 infections.

5 Oct 2023

Green, matcha, and black tea: Effective weapons against Omicron subvariants, research reveals

The efficacy of tea and its catechins in deactivating the Omicron subvariant.

5 Oct 2023

Could infants' robust immune responses reshape future vaccination strategies?

Utilizing next-gen sequencing techniques, researchers analyzed infants' immune responses to infections, uncovering a predominant innate immune activation unlike adults and older children. This insight could steer child vaccination research and pediatric infection management strategies, potentially revolutionizing infant healthcare.

3 Oct 2023

SARS-CoV-2 infection in coronary vessels linked to cardiovascular complications

Researchers reported that the increased long-term risk of acute cardiovascular complications associated with COVID-19 is linked to SARS-CoV-2 infecting coronary vessels and inducing the formation of plaques.

3 Oct 2023

Could seaweeds be the superfood and medicine of the future?

Researchers consolidate the diverse nutritional and medicinal benefits of seaweeds, touting their potential in food, nutraceuticals, and pharmaceuticals. The study also highlights challenges and opportunities in industrial applications, calling for more research to optimize extraction and refinement processes.

2 Oct 2023

Long COVID unmasked: Patients share varied physical, mental, and social challenges

Patient experiences of the post-acute sequelae of coronavirus disease 2019 (COVID-19) or long COVID.

2 Oct 2023

New study reveals BA.2.86 subvariant's surprising dance with antibodies

Researchers examined the antigenicity of the emerging SARS-CoV-2 subvariant BA.2.86, finding that it is not resistant to neutralizing antibodies from previously infected or vaccinated individuals, although it does show increased binding affinity to the ACE-2 receptor. The study highlights the subvariant's sensitivity and resistance to different classes of monoclonal antibodies, offering insights for future treatment and vaccine development.

2 Oct 2023

Maternal COVID-19 shots significantly lowered infant hospitalizations during Omicron wave

Study found that maternal COVID-19 vaccination during pregnancy significantly reduces the risk of COVID-19-related hospitalizations in infants under six months, particularly boosting protection during the first three months of life. With 78% of the hospitalized infants born to unvaccinated mothers, the research emphasizes the crucial role of maternal vaccination in safeguarding infants too young for vaccination.

2 Oct 2023

New study reveals alarming cardiovascular risks from COVID

The study published in Nature Cardiovascular Research reveals that SARS-CoV-2, the virus causing COVID-19, can directly infect coronary vessels and arterial plaques, heightening the risk of cardiovascular complications like heart attacks and strokes. These findings offer critical insights into the increased long-term cardiovascular risks for COVID-19 survivors and open new avenues for targeted therapies.

1 Oct 2023

Aerosolized ACE2 neutralizes COVID-19 variants in lab and mice tests

Researchers from the University of Texas Southwestern have developed an aerosolized, mutated form of ACE2 that effectively neutralizes various SARS-CoV-2 variants in both cell cultures and mice. The study suggests that this modified ACE2 has promising preventive and therapeutic potential against COVID-19, especially with its easy aerosolized administration.

28 Sep 2023

Primate model unlocks clues to long-COVID's impact on blood sugar, hints at vaccine benefits

The study uses a non-human primate model to explore the link between long-COVID and disruptions in glucose metabolism, finding a positive correlation. Vaccination appeared to improve glycemic control, suggesting a possible role in managing long-COVID symptoms.

28 Sep 2023

Severe Acute Respiratory News and Research

Next-gen intranasal vaccine takes on measles, mumps, and multiple COVID-19 variants in one shot

Antigenic cartography decodes the mysteries of SARS-CoV-2 variants and vaccines

Decoding the twist: Coronavirus spike proteins reveal their intricate invasion dance

Novavax vaccine shows resilient defense against symptomatic COVID-19 despite Omicron challenge

The potential benefits of ribavirin and pleconaril treatment on type 1 diabetes

COVID-19's ripple effect: South African TB diagnostics take a hit

Nirmatrelvir and ritonavir combo cuts COVID-19 risks for high-vulnerability groups

Protein recombinant vaccine NVX-CoV2373 confers protection during Omicron dominant period in Italy

Inhaled nitric oxide shows promise as treatment for COVID-19 respiratory failure

Why are most Americans skipping the COVID-19 booster?

Green, matcha, and black tea: Effective weapons against Omicron subvariants, research reveals

Could infants' robust immune responses reshape future vaccination strategies?

SARS-CoV-2 infection in coronary vessels linked to cardiovascular complications

Could seaweeds be the superfood and medicine of the future?

Long COVID unmasked: Patients share varied physical, mental, and social challenges

New study reveals BA.2.86 subvariant's surprising dance with antibodies

Maternal COVID-19 shots significantly lowered infant hospitalizations during Omicron wave

New study reveals alarming cardiovascular risks from COVID

Aerosolized ACE2 neutralizes COVID-19 variants in lab and mice tests

Primate model unlocks clues to long-COVID's impact on blood sugar, hints at vaccine benefits

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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