Severe Acute Respiratory News and Research

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Novel self-amplifying RNA vaccine confers durable protection against COVID-19, reduces viral shedding in primate study

A self-amplifying replicon RNA vaccine against SARS-CoV-2 can elicit durable and protective immunity in pigtail macaques, even after neutralizing antibody responses have waned to undetectable levels.

23 Apr 2023

Study reveals CMPK-2 protein-coding gene as a potent inhibitor of flaviviruses

CMPK2 identified as a potential pan-flavivirus inhibitor, restricting virus replication and providing a basis for developing new antiviral treatments.

23 Apr 2023

An exploration of the pathophysiological factors and abnormalities of coagulation of long-COVID

Researchers explored the pathophysiological variables and coagulation abnormalities associated with long coronavirus disease (COVID).

21 Apr 2023

Omicron spike N679K mutation acts as a loss-of-function mutation attenuating SARS-CoV-2 in vitro & in vivo

Researchers explored the impact of a loss-of-function mutation in the SARS-CoV-2 Omicron variants on the expression of the spike protein.

20 Apr 2023

Protective mucosal and systemic immunity provided by a single-dose novel live-attenuated intranasal SARS-CoV-2 vaccine candidate

Researchers explored the protective systemic and mucosal immunity provided by a single dose of a live-attenuated SARS-CoV-2 vaccine candidate.

20 Apr 2023

Study indicates that SARS-CoV-2 has evolved to gain increased replicative fitness and become well-adapted in epithelial cells of human airways

Researchers explored increasing replicative fitness of emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants

20 Apr 2023

Protein OCLN found to play crucial role in SARS-CoV-2 cell-to-cell transmission

Research explains how the SARS-CoV-2 virus spreads efficiently by directly infecting neighboring cells through a process called cell-to-cell transmission. The virus uses a protein called occludin (OCLN) to enter the cells and causes syncytium formation, which leads to viral spread.

20 Apr 2023

Combination of fluvoxamine and inhaled budesonide reduces severe COVID-19 in high-risk outpatients

Research reports the results of a randomized, placebo-controlled trial that investigated the effects of combining fluvoxamine and inhaled budesonide for preventing disease progression in high-risk outpatients with COVID-19. The study found that the combination treatment reduced the incidence of severe disease requiring advanced care.

20 Apr 2023

Observational cohort study of long COVID among 2 million elderly adults

Research estimates the incidence of long COVID and long Flu among Medicare patients using the World Health Organization (WHO) consensus definition. The study compares the incidence, symptomatology, and healthcare utilization between long COVID and long flu patients.

20 Apr 2023

Early use of dexamethasone associated with reduced mortality in hospitalized COVID-19 requiring breathing support

In a recent study published in the journal JAMA Network Open, researchers examined the clinical use of dexamethasone for hospitalized patients with coronavirus disease 2019 (COVID-19) respiratory illness and explored the heterogeneity of treatment outcomes across different subgroups.

19 Apr 2023

Can SARS-CoV-2 infection cause diabetes?

This paper reports a population-based cohort study conducted in British Columbia, Canada, which found that SARS-CoV-2 infection is associated with a higher risk of diabetes, particularly among those with severe COVID-19 disease.

19 Apr 2023

Next-generation vaccine strategies to combat current and emerging SARS-CoV-2 variants

Announcing a new article publication for Zoonoses journal. Vaccines are among the most effective medical countermeasures against infectious diseases.

19 Apr 2023

Understanding the probable transmission of SARS-CoV-2 from lion to zookeepers

Researchers explored the possible transmission of SARS-CoV-2 to zoo employees from an African lion.

19 Apr 2023

Assessing the efficacy, safety and tolerability of AXA1125 in long COVID patients

Researchers evaluated the effectiveness of endogenous metabolic modulator, AXA1125.

19 Apr 2023

Adapting for endemic not pandemic: Time to reassess universal masking in healthcare

Researchers discuss the changing context of universal masking in healthcare settings amid the COVID-19 pandemic and argue for a dynamic, adaptable approach to infection prevention policies.

19 Apr 2023

New DCFHP-alum COVID-19 vaccine candidate shows durable, broad-spectrum protection in non-human primates

The newly developed DCFHP-alum COVID-19 vaccine candidate is affordable and effective for mass vaccination.

18 Apr 2023

The impact of SARS-CoV-2 infection in pregnancy on infant growth

Researchers discussed the impact of SARS-CoV-2 infection in pregnancy on infant growth.

18 Apr 2023

Unravelling the factors influencing host tropism of SARS-CoV-2-related bat coronaviruses

Researchers investigated the tropism of SC2r-CoVs infecting Rhinolophus bats.

18 Apr 2023

Was resuming in-person vs virtual instruction for school students associated with differences in COVID-19 incidence?

Researchers assessed whether in-person education increased coronavirus disease 2019 incidence.

18 Apr 2023

A highly efficient platform for detection of SARS-CoV-2 variants

The recent outbreak of the coronavirus disease 2019 (COVID-19) pandemic and the continuous evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have highlighted the significance of new detection methods for global monitoring and prevention.

17 Apr 2023

Severe Acute Respiratory News and Research

Novel self-amplifying RNA vaccine confers durable protection against COVID-19, reduces viral shedding in primate study

Study reveals CMPK-2 protein-coding gene as a potent inhibitor of flaviviruses

An exploration of the pathophysiological factors and abnormalities of coagulation of long-COVID

Omicron spike N679K mutation acts as a loss-of-function mutation attenuating SARS-CoV-2 in vitro & in vivo

Protective mucosal and systemic immunity provided by a single-dose novel live-attenuated intranasal SARS-CoV-2 vaccine candidate

Study indicates that SARS-CoV-2 has evolved to gain increased replicative fitness and become well-adapted in epithelial cells of human airways

Protein OCLN found to play crucial role in SARS-CoV-2 cell-to-cell transmission

Combination of fluvoxamine and inhaled budesonide reduces severe COVID-19 in high-risk outpatients

Observational cohort study of long COVID among 2 million elderly adults

Early use of dexamethasone associated with reduced mortality in hospitalized COVID-19 requiring breathing support

Can SARS-CoV-2 infection cause diabetes?

Next-generation vaccine strategies to combat current and emerging SARS-CoV-2 variants

Understanding the probable transmission of SARS-CoV-2 from lion to zookeepers

Assessing the efficacy, safety and tolerability of AXA1125 in long COVID patients

Adapting for endemic not pandemic: Time to reassess universal masking in healthcare

New DCFHP-alum COVID-19 vaccine candidate shows durable, broad-spectrum protection in non-human primates

The impact of SARS-CoV-2 infection in pregnancy on infant growth

Unravelling the factors influencing host tropism of SARS-CoV-2-related bat coronaviruses

Was resuming in-person vs virtual instruction for school students associated with differences in COVID-19 incidence?

A highly efficient platform for detection of SARS-CoV-2 variants

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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