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Do phthalates in face masks pose health hazards with increased usage during the COVID-19 pandemic?

In a new study, researchers investigated the presence of phthalic acid esters (PAEs) or phthalates in commercially available face masks to assess the health risks associated with the increased use of face masks during the coronavirus disease 2019 (COVID-19) pandemic.

17 Oct 2022

Investigating plasma signatures of platelet-derived proteins in acute pulmonary embolism

In a new study, researchers determined plasma signatures of proteins related to or derived from platelets in acute isolated pulmonary embolism (iPE) and deep vein thrombosis-associated PE (DVT-PE), compared to isolated DVT (iDVT).

17 Oct 2022

Mouse model reveals how RNA splicing defects contribute to neurodegeneration in Alzheimer's disease

Researchers have puzzled over the neurodegenerative disorder Alzheimer's disease for decades, but treatments to stop or reverse the disease's effects on the brain have remained elusive.

13 Oct 2022

Metabolite discovery offers a potential way to address metabolic conditions

"Metabolism" describes the body's chemical changes that create the necessary materials for growth and overall health. Metabolites are the substances made and used during these metabolic processes-;or, as a new discovery out of Scripps Research and its drug development arm, Calibr, indicates, they could also be potent molecules for treating severe diseases.

13 Oct 2022

Key biophysical attributes of a self-amplifying viral RNA vaccine developed for SARS-CoV-2

Researchers used various analytical characterization techniques to determine the biophysical attributes of the Imperial College London self-amplifying viral RNA vaccine (IMP-1) developed for SARS-CoV-2.

5 Oct 2022

Small antiviral molecules termed assembly modulators show therapeutic efficacy against cancer

In a new study, researchers evaluated the anti-cancer therapeutic efficacy of two structurally-unrelated small molecules, PAV-617 and PAV-951.

4 Oct 2022

Stanford researchers discover a sustainable way to produce cancer-fighting compound in the lab

Stanford University researchers have discovered a rapid and sustainable way to synthetically produce a promising cancer-fighting compound right in the lab.

3 Oct 2022

Researchers report aminoadamantanes that block SARS-CoV-2 infection by S-nitrosylation of the host ACE2 protein

Researchers investigated the use of aminoadamantane nitrate compounds as anti-SARS-CoV-2 drugs.

3 Oct 2022

Structural analysis of monkeypox virus to guide the development of broad antiviral agents

In a new study, researchers explored the crystalline structure of the monkeypox (MPX) virus (MPXV) and the complex of VP39, a 2′-O-RNA methyltransferase (MTase) and sinefungin, a pan-MTase inhibitor.

30 Sep 2022

Brazilian study reveals the effects of SARS-CoV-2 infection on the central nervous system

A Brazilian study published in the journal PNAS describes some of the effects infection by SARS-CoV-2 can have on the central nervous system.

30 Sep 2022

Plasma proteome signature predictive of occurrence of persistent symptoms following SARS-CoV-2 infection

In a new study, researchers performed a proteomic multiple-reaction monitoring analysis of 91 pre-selected proteins using the plasma samples of 156 healthcare workers (HCW) in the United Kingdom (UK).

30 Sep 2022

Associations between potential endocrine-disrupting chemicals and female fertility in women attending fertility clinics

Researchers explored the correlation between female fertility and chemical mixtures.

30 Sep 2022

How are diet and exercise in bodybuilders associated with the gut microbiota and metabolites?

A recent study explored the diet-exercise-gut microbiome dynamics in male bodybuilders.

30 Sep 2022

Blood test could predict people's likelihood of developing long Covid

A blood test taken at the time of Covid-19 infection could predict who is most likely to develop long Covid, suggests a new small-scale study led by UCL researchers.

28 Sep 2022

New lab technique could spark a 'paradigm shift' in testing protein-based drugs

New Jersey Institute of Technology researchers have unveiled a new lab technique they say represents a "paradigm shift" in how pharmaceutical laboratories test and produce new protein-based drugs, such as therapeutic monoclonal antibodies being developed to treat a variety of diseases, from cancers to infectious diseases.

27 Sep 2022

Singapore researchers identify protein that transports degraded membrane lipids out of lysosomes

Researchers at Duke-NUS Medical School and colleagues in Singapore have identified a protein that transports degraded membrane lipids out of lysosomes, cellular organelles that are the breakdown factories of cells.

27 Sep 2022

Mutation in newly discovered small protein linked to increase in Alzheimer's disease risk

A mutation in a newly discovered small protein is connected to a significant increase in the risk for Alzheimer's disease, expanding the known gene targets for the disease and presenting a new potential avenue for treatment, according to a new USC study.

21 Sep 2022

Researchers provide critical insights into the molecular mechanisms underlying lysophagy

Autophagy is a self-degradation process that cells use to remove unneeded or damaged components. There are several forms of autophagy, including macroautophagy, which is a bulk degradation system used to target materials in the cell's cytosol to organelles called lysosomes for enzymatic breakdown.

20 Sep 2022

New mechanistic insights on the origin of SARS-CoV-2-induced neurological disorders

Researchers explored the effect of SARS-CoV-2 exposure on the brain.

20 Sep 2022

O-linked sialoglycans affect SARS-CoV-2 spike cleavage

In a recent study posted to the bioRxiv* preprint server, researchers from Spain, the United Kingdom, and the United States used chemical tools to uncover the molecular details of glycan-mediated modulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) processing.

19 Sep 2022

Spectrometry News and Research

Do phthalates in face masks pose health hazards with increased usage during the COVID-19 pandemic?

Investigating plasma signatures of platelet-derived proteins in acute pulmonary embolism

Mouse model reveals how RNA splicing defects contribute to neurodegeneration in Alzheimer's disease

Metabolite discovery offers a potential way to address metabolic conditions

Key biophysical attributes of a self-amplifying viral RNA vaccine developed for SARS-CoV-2

Small antiviral molecules termed assembly modulators show therapeutic efficacy against cancer

Stanford researchers discover a sustainable way to produce cancer-fighting compound in the lab

Researchers report aminoadamantanes that block SARS-CoV-2 infection by S-nitrosylation of the host ACE2 protein

Structural analysis of monkeypox virus to guide the development of broad antiviral agents

Brazilian study reveals the effects of SARS-CoV-2 infection on the central nervous system

Plasma proteome signature predictive of occurrence of persistent symptoms following SARS-CoV-2 infection

Associations between potential endocrine-disrupting chemicals and female fertility in women attending fertility clinics

How are diet and exercise in bodybuilders associated with the gut microbiota and metabolites?

Blood test could predict people's likelihood of developing long Covid

New lab technique could spark a 'paradigm shift' in testing protein-based drugs

Singapore researchers identify protein that transports degraded membrane lipids out of lysosomes

Mutation in newly discovered small protein linked to increase in Alzheimer's disease risk

Researchers provide critical insights into the molecular mechanisms underlying lysophagy

New mechanistic insights on the origin of SARS-CoV-2-induced neurological disorders

O-linked sialoglycans affect SARS-CoV-2 spike cleavage

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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