Status Epilepticus News and Research

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AES released list of new fellowship awardees for organization's early-career awards

Today, the American Epilepsy Society (AES) released its list of new fellowship awardees, naming 15 recipients for the organization's early-career awards.

15 Apr 2014

SAGE Therapeutics doses first patient in SAGE-547 Phase 1/2 trial for treatment of SRSE

SAGE Therapeutics, a biopharmaceutical company developing novel medicines to treat life-threatening and rare central nervous system (CNS) disorders, today announced dose initiation of the first patient in a Phase 1/2 clinical trial of SAGE-547, a neuroactive steroid, in super-refractory status epilepticus (SRSE), a critical condition in which the brain is in a state of persistent seizure.

27 Mar 2014

SAGE Therapeutics announces completion of $38 million Series C financing

SAGE Therapeutics, a biopharmaceutical company developing novel medicines to treat specialty, critical and orphan central nervous system (CNS) disorders, today announced the successful completion of a $38 million Series C financing. OrbiMed Advisors, LLC, EcoR1 Capital Management, Foresite Capital Management and two undisclosed blue chip public investment funds joined existing investors Third Rock Ventures and ARCH Venture Partners.

13 Mar 2014

Children with FSE who receive earlier treatment with AEDs experience reduction in duration of seizure

New research shows that children with febrile status epilepticus (FSE) who receive earlier treatment with antiepileptic drugs (AEDs) experience a reduction in the duration of the seizure.

6 Feb 2014

Study shows VEEG telemetry monitoring with early cessation of AED therapy is safe, effective

Patients with epilepsy often undergo evaluation by concurrent video and EEG monitoring (vEEG) for therapeutic planning, including possible epilepsy surgery. Seizures during monitoring increase the diagnostic yield and requires the withdrawal of anticonvulsant drugs (AEDs) to allow seizures to occur.

9 Dec 2013

Prolonged febrile seizures can affect pediatric patients

A long-standing hypothesis holds that prolonged febrile (fever induced) seizures, the most common form of childhood convulsive status epilepticus, cause mesial temporal sclerosis. CSE is a single seizure, or two or more seizures between which consciousness is not regained, lasting for more than 30 minutes.

9 Dec 2013

$Management of refractory convulsive status epilepticus varies at different medical centers$

Management of refractory convulsive status epilepticus varies at different medical centers

The management of refractory convulsive status epilepticus varies at different medical centers and from patient to patient. Rapid success in aborting these non-stop seizures is crucial as the risk of neurological damage is high and, though rare, may result in death depending on seizure duration. By pooling data and analyzing current RCSE management practices, researchers representing a multicenter network of tertiary referral hospitals in the U.S. conducted a study that could lead to improved treatment outcomes for potentially life-threatening seizures.

9 Dec 2013

Duke Medicine researchers identify molecular target to prevent onset of epilepsy

Duke Medicine researchers have identified a receptor in the nervous system that may be key to preventing epilepsy following a prolonged period of seizures.

21 Jun 2013

Targeting particular signaling pathway can help prevent temporal lobe epilepsy, scientists report

Temporal lobe epilepsy, the most common form of epilepsy, is characterized by recurrent seizures throughout life and often behavioral abnormalities, with devastating impacts on patients and their families. Unfortunately, the condition is often not responsive to anticonvulsants. Now scientists report online June 20 in the Cell Press journal Neuron that targeting a particular signaling pathway in mice can prevent the development of temporal lobe epilepsy with just two weeks of treatment, offering hope that researchers will be able to develop effective drugs to mitigate recurrent seizures and the development of epilepsy.

21 Jun 2013

Study examines developmental delays in children within six weeks of CSE

Researchers from the UK determined that developmental delays are present in children within six weeks following convulsive status epilepticus -a seizure lasting longer than thirty minutes.

8 Apr 2013

EEG can be used to identify treatable causes of common disorders in hospital patients, say researchers

EEG Could be More Widely Used to Identify Treatable Causes of Common Disorders in Hospital Patients, Say Researchers in Mayo Clinic Proceedings.

2 Apr 2013

Management of hospital-onset seizures lacks standards

Seizures in patients admitted to hospital for nonseizure reasons – hospital-onset seizures – largely affect those without any history of seizures, often recur, and are linked to a high mortality, according to a study in JAMA Neurology.

21 Jan 2013

UK and U.S.researchers collaborate to determine long-term outcomes of children with epilepsy

In the first study of its kind, researchers from five institutions from the UK and U.S. collaborating to determine the long-term outcomes of children with epilepsy found that outcomes varied despite similar short-term morbidity among the originally surveyed children when they were followed up within 10 years post-occurrence.

4 Dec 2012

$Most refractory status epilepticus patients have poor functional outcome$

Most refractory status epilepticus patients have poor functional outcome

Three-quarters of refractory status epilepticus patients have a poor functional outcome, which is linked to drug-induced coma and severe encephalographic suppression, say US scientists.

30 Oct 2012

Febrile seizures increase hippocampal injury risk

Children with febrile status epilepticus are at risk for hippocampal injury and show abnormalities in the development of this brain area, show findings from a prospective multicenter study.

16 Aug 2012

Roseola virus behind one-third of febrile seizures in young children

Researchers have discovered that infection with two of the roseola viruses, which are responsible for a common childhood rash, appear to increase a child’s risk for prolonged seizures and fever and may increase future temporal lobe epilepsy risk.

20 Jun 2012

Study strengthens link between HHV-6B and mesial temporal lobe epilepsy

A ten-year NIH-funded study has determined that a third of infants with prolonged seizures and fever suffer from either a new or reactivated roseola virus infection. Roseola viruses are the cause of the common childhood rash, but can also cause limbic encephalitis, a condition that frequently progresses to epilepsy. Investigators discovered one of the roseola viruses, human herpesvirus-6B (HHV-6B) in the blood of 32% of 169 infants with prolonged seizures, a condition known as status epilepticus.

15 Jun 2012

Roseola virus accounts for one third of febrile status epilepticus cases

New research shows that human herpesviruses (HHV)-6B and HHV-7, commonly know as roseola virus), account for one third of febrile status epilepticus (FSE) cases. Results of the FEBSTAT prospective study now available in Epilepsia, a journal published by Wiley-Blackwell on behalf of the International League Against Epilepsy (ILAE), suggest that HHV-6B may be involved in the development of epilepsy and further research is urgently needed.

14 Jun 2012

Midazolam autoinjector pen more effective in treating status epilepticus

Results have just been released from an NIH study conducted at multiple sites, including the University of Kentucky, indicating that an autoinjector pen is a faster and possibly more effective way for emergency medical personnel to treat serious seizures.

17 Feb 2012

Intramuscular midazolam effective in treating status epilepticus

Drug delivery directly into muscle using an autoinjector is faster and may be more effective in stopping prolonged seizures, according to a study sponsored by the National Institutes of Health and conducted by a Wayne State University School of Medicine researcher.

17 Feb 2012

Status Epilepticus News and Research

AES released list of new fellowship awardees for organization's early-career awards

SAGE Therapeutics doses first patient in SAGE-547 Phase 1/2 trial for treatment of SRSE

SAGE Therapeutics announces completion of $38 million Series C financing

Children with FSE who receive earlier treatment with AEDs experience reduction in duration of seizure

Study shows VEEG telemetry monitoring with early cessation of AED therapy is safe, effective

Prolonged febrile seizures can affect pediatric patients

Management of refractory convulsive status epilepticus varies at different medical centers

Duke Medicine researchers identify molecular target to prevent onset of epilepsy

Targeting particular signaling pathway can help prevent temporal lobe epilepsy, scientists report

Study examines developmental delays in children within six weeks of CSE

EEG can be used to identify treatable causes of common disorders in hospital patients, say researchers

Management of hospital-onset seizures lacks standards

UK and U.S.researchers collaborate to determine long-term outcomes of children with epilepsy

Most refractory status epilepticus patients have poor functional outcome

Febrile seizures increase hippocampal injury risk

Roseola virus behind one-third of febrile seizures in young children

Study strengthens link between HHV-6B and mesial temporal lobe epilepsy

Roseola virus accounts for one third of febrile status epilepticus cases

Midazolam autoinjector pen more effective in treating status epilepticus

Intramuscular midazolam effective in treating status epilepticus

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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