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The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock

In mammals, including humans, a master clock in the brain and subordinate clocks found in organs throughout the body coordinate daily, or circadian, rhythms of behavior and physiology.

8 Aug 2006

Humidified air inhalation for treating croup

For decades, parents and pediatricians have relied on humid air to relieve the barking cough and noisy breathing of croup, a common childhood condition that sometimes sends worried families to the emergency room.

19 Jul 2006

Obesity associated with less favorable outcome after radiation therapy for prostate cancer

Obese men with prostate cancer are at higher risk for treatment failure after primary radiation therapy, according to a new study.

27 Jun 2006

3 new genes implicated in rheumatoid arthritis

Researchers continue to search for genetic clues into rheumatoid arthritis (RA), a chronic inflammatory joint disease.

27 Jun 2006

Doctors who take part in clinical trials usually prescribe the drug

Doctors are often asked by pharmaceutical companies to take part in clinical trials and little is known about the effects of such participation on their prescribing patterns.

21 Jun 2006

Safe for cystic fibrosis patients to stop using inhaled corticosteroids

In comparison to cystic fibrosis (CF) patients who regularly use inhaled corticosteroid, those who did not use these drugs for six months exhibited no positive or negative effects in terms of major disease factors.

18 Jun 2006

Naltrexone relief for Crohn's sufferers

Study suggests that a drug used to ease symptoms of alcohol and drug addiction may also bring relief to people with Crohn's disease, a chronic inflammatory disorder of the intestine that affects an estimated 500,000 Americans.

31 May 2006

Thalomid gets FDA approval to treat multiple myeloma

Thalomid (thalidomide) has been given a new lease of life following the United States Food and Drug Administration (FDA) approval for the drug to be used in combination with the steroid dexamethasone for the treatment of newly diagnosed multiple myeloma.

29 May 2006

Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia

Long-term therapy with some antiepileptic drugs and antibiotics can cause osteomalacia, a condition marked by softening of the bones that is usually the result of vitamin D and calcium deficiency.

16 May 2006

Inhaled corticosteroids can reduce breathing problems in children at high risk for asthma

Studies in older children and adults show that the most effective long-term control medicine for persistent asthma (symptoms more than two days a week or more than twice a month at night) is inhaled corticosteroids, which reduce airway swelling and help prevent asthma symptoms (e.g., asthma attacks).

10 May 2006

$Childhood arthritis increases the risk of fractures$

Childhood arthritis increases the risk of fractures

Childhood arthritis increases the risk of fractures, particularly during adolescence, according to a large study of British patient records. The researchers say that more targeted treatments promoting bone health would benefit patients with childhood-onset arthritis throughout their lifespan.

8 May 2006

The efficacy and safety of Rituximab in patients with active rheumatoid arthritis

Drugs aimed at suppressing inflammation-provoking cytokines--specifically those linked to T-cells--have improved the treatment of rheumatoid arthritis (RA), a chronic, inflammatory autoimmune disease. Still, the frequency of remission achieved by these biologic agents remains below 50 percent.

3 May 2006

Corticosteroids do not improve survival in patients with late-stage acute respiratory distress syndrome

The study is the first multi-center randomized clinical trial to evaluate the effects of moderate doses of steroids in ARDS patients when treatment is started 7 days or more after the onset of the condition.

20 Apr 2006

Inhaled corticosteroids ease asthma symptoms

Adults and children with asthma will breathe deeper and have better control over their asthma with inhaled corticosteroids than with the medicine cromolyn, according to a new review of recent studies comparing the two treatments.

18 Apr 2006

Locally injected steroids may not do much good for chronic headache pain

Locally injected steroids apparently don't enhance treatments for acute headache or migraine pain.

18 Apr 2006

Telithromycin antibiotic may help reduce some symptoms of a bad asthma attack

The researchers however believe the positive effects of the drug may be as a result of its impact on two bacteria - Chlamydophila pneumoniae and Mycoplasma pneumoniae - found present in 61% of patients in the study.

13 Apr 2006

Antibiotic telithromycin is effective at treating acute asthma attacks

Researchers have demonstrated that an antibiotic is effective at treating acute asthma attacks, potentially providing a new way to help asthma sufferers.

13 Apr 2006

Scientists find that growth hormone is produced in the brain

Scientists have found that growth hormone, a substance that is used for body growth, is produced in the brain, according to an article published in the Proceedings of the National Academy of Sciences.

11 Apr 2006

Intrahepatic cholestasis of pregnancy as an indicator of liver and biliary diseases

A retrospective case-control study of 21,008 women in Finland has found that those with intrahepatic cholestasis of pregnancy (ICP), an itchy skin condition when bile gets backed up in the liver, are significantly more likely to suffer other liver diseases later in life.

7 Apr 2006

Targeting the inflamed synovium: The quest for specificity

In the April 2006 issue of Arthritis & Rheumatism, noted rheumatology specialists with Kings College London, Dr. Toby Garrood and Dr. Costantino Pitzalis offer an overview of recent breakthroughs and a preview of future directions in this critical quest for specificity.

4 Apr 2006