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New series of human drug targets available to all researchers

The Structural Genomics Consortium (SGC), an Anglo-Canadian charitable consortium of public and private agencies including Oxford University, announced recently that it has delivered its first 50 human and malaria protein structures into the public domain on budget and two months ahead of schedule.

6 Jun 2005

Gene research may help explain how adorable children become surly teenagers

University of Utah researchers showed that a fruit fly gene is crucial for determining when juveniles begin to mature into adults, and how the transformation initially proceeds. Understanding this process in humans may help explain how adorable children become surly teenagers.

3 Jun 2005

Alarming trends among steroid users

Major findings in a new survey of 500 steroid users reveal specific, alarming trends: most are non-athletes whose sole intention is to improve their physical appearance; users are taking larger doses than previously recorded; and even though nearly all admitted to adverse side effects, health concerns are not enough to deter their steroid use.

2 Jun 2005

Study links TNF to androgen deficiency in rheumatoid arthritis patients and suggest a novel pathway in inflammation

A protein involved in multiple cell functions, tumor necrosis factor (TNF) is perhaps best known for provoking destructive inflammation. Recently, drugs blocking the action of TNF have shown promise in the early treatment of rheumatoid arthritis (RA).

2 Jun 2005

Steroid treatment for prematurity put to the test

Babies whose mothers received steroid injections before giving birth have no higher risk of heart disease at age 30 than those whose mothers received a placebo treatment.

30 May 2005

Stimulating innate immunity helps ease Crohn's disease symptoms

Like throwing oil on a fire or prescribing a high cholesterol diet for heart patients, gastroenterologists traditionally have believed that it would not be a good idea to stoke up the body's immune system to treat Crohn's disease.

26 May 2005

Tragic death of 5 year old asthma patient was avoidable and due to complacency of health professionals

At a fatal accident inquiry a sheriff has hit out at the "complacency" of health professionals and a drugs manufacturer over the safety of an asthma inhaler steroid.

25 May 2005

New Symbicort single inhaler asthma treatment gives much better asthma control

A new asthma treatment regimen promises to deliver a great improvement in key measures of asthma control and should simplify the management of the disease compared with other treatments.

23 May 2005

Study finds benefits, less organ rejection using immunosuppressive combination for heart transplants

A new study led by researchers at the UCLA Heart Transplant Program showed that one particular combination using tacrolimus (TAC or PrografÒ also known as FK506) had significant anti-rejection benefits for heart transplant patients over other combinations.

22 May 2005

New drug fluticasone was just as effective as beclomethasone and budesonide at opening up constricted breathing passages

A new inhaled drug for chronic asthma may improve lung function as much as two older inhaled asthma drugs but at half the dose, a review of recent studies concludes.

19 May 2005

Remicade shows promise in treating ulcerative colitis

Results from two Phase III, placebo-controlled clinical trials found that approximately two-thirds of patients with moderate to severe, active ulcerative colitis (UC) treated with Remicade (infliximab, 5mg/kg) demonstrated a significant improvement in symptoms.

16 May 2005

Hormone Replacement Therapy (HRT) has a beneficial impact on cardiovascular health in hypertensive postmenopausal women

Oral Hormone Replacement Therapy (HRT) seems to have a beneficial impact on cardiovascular health in hypertensive postmenopausal women, researchers reported at the American Society of Hypertension Twentieth Annual Meeting held in San Francisco.

16 May 2005

Changes in certain brain receptors can affect seizures and anxiety during the menstrual cycle

A new UCLA study shows that changes in certain brain receptors can affect seizures and anxiety during the menstrual cycle--findings that could lead to novel therapies for premenstrual dysphoric disorder (PMDD, formerly known as PMS) and other central nervous system symptoms associated with the menstrual cycle.

16 May 2005

Researchers identify mechanism which increases lung inflammation, making Chronic Obstructive Pulmonary Disorder (COPD) more severe

An international team of researchers has identified a mechanism which increases lung inflammation, making Chronic Obstructive Pulmonary Disorder (COPD) more severe, and potentially points towards new treatments.

11 May 2005

Simple and efficient method for creation of novel protein functions in an existing protein scaffold

By designing a molecular bridge, scientists at the University of Illinois at Urbana-Champaign have forged a successful pathway through a complex ocean of barriers: They've changed the function of a protein using a co-evolution approach.

8 May 2005

Modification of surgery used to correct flatfoot deformity may reduce pain and improve outcomes

Virginia Commonwealth University physicians and engineers studying foot and ankle biomechanics have developed a modification to a procedure used to correct adult-acquired flatfoot deformity that may reduce the pressure and pain that often persists after surgery.

2 May 2005

International internet drug ring shattered

Drug Enforcement Administration (DEA) Administrator Karen P. Tandy has announced the results of Operation “Cyber Chase”, a year-long Organized Crime Drug Enforcement Task Force (OCDETF) investigation that targeted international Internet pharmaceutical traffickers operating in the United States, India, Asia, Europe and the Caribbean. These e-traffickers distributed drugs world-wide using “rogue” Internet pharmacies.

23 Apr 2005

High levels of immunosuppressant may lead to tumor recurrence

A new study on the incidence of liver cancer after transplant found that high levels of the immunosuppressant cyclosporine favored tumor recurrence and identified blood levels of the drug that should not be exceeded. Lower levels of cyclosporine levels did not affect rejection rates.

22 Apr 2005

Clinical study of MDX-010/MDX-1379 combination shows durable responses in patients with metastatic melanoma

Medarex, Inc. and Bristol-Myers Squibb Company announced today that complete or partial responses in seven of 56 patients with metastatic melanoma showed durability ranging from four months to the longest still ongoing at over 34 months, with five of the seven responses ongoing for more than two years.

20 Apr 2005

NSAIDs okay for tonsillectomy, new study finds

When children have their tonsils removed, nonsteroidal anti-inflammatory drugs can be used for pain relief with no significant increase in bleeding and with less nausea and vomiting, according to a systematic review of current evidence.

19 Apr 2005

Steroid News and Research

New series of human drug targets available to all researchers

Gene research may help explain how adorable children become surly teenagers

Alarming trends among steroid users

Study links TNF to androgen deficiency in rheumatoid arthritis patients and suggest a novel pathway in inflammation

Steroid treatment for prematurity put to the test

Stimulating innate immunity helps ease Crohn's disease symptoms

Tragic death of 5 year old asthma patient was avoidable and due to complacency of health professionals

New Symbicort single inhaler asthma treatment gives much better asthma control

Study finds benefits, less organ rejection using immunosuppressive combination for heart transplants

New drug fluticasone was just as effective as beclomethasone and budesonide at opening up constricted breathing passages

Remicade shows promise in treating ulcerative colitis

Hormone Replacement Therapy (HRT) has a beneficial impact on cardiovascular health in hypertensive postmenopausal women

Changes in certain brain receptors can affect seizures and anxiety during the menstrual cycle

Researchers identify mechanism which increases lung inflammation, making Chronic Obstructive Pulmonary Disorder (COPD) more severe

Simple and efficient method for creation of novel protein functions in an existing protein scaffold

Modification of surgery used to correct flatfoot deformity may reduce pain and improve outcomes

International internet drug ring shattered

High levels of immunosuppressant may lead to tumor recurrence

Clinical study of MDX-010/MDX-1379 combination shows durable responses in patients with metastatic melanoma

NSAIDs okay for tonsillectomy, new study finds

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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