Toxin News and Research

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UTSW researchers identify the structure of a key cell-surface protein

UT Southwestern researchers have identified the structure of a key member of a family of proteins called nicotinic acetylcholine receptors in three different shapes.

17 Mar 2021

New approach may lead to novel treatments for renal fibrosis

Ageing is a common factor in many diseases. So, what if it were possible to treat them by acting on the causes of ageing or, more specifically, by acting on the shortening of telomeres, the structures that protect chromosomes?

16 Mar 2021

Diphtheria is evolving to become antibiotic-resistant and could lead to vaccine escape

Diphtheria - a relatively easily-preventable infection - is evolving to become resistant to a number of classes of antibiotics and in future could lead to vaccine escape, warn an international team of researchers from the UK and India.

8 Mar 2021

'Miracle poison' can target a variety of different proteins

Researchers prove they can engineer proteins called proteases to find new targets with high selectivity, a critical advance toward potential new treatments for everything from neuro-regeneration to cytokine storm.

25 Feb 2021

Study: Interbacterial toxins may contribute to bacterial genetic diversity

A toxin produced by bacteria as a defence mechanism causes mutations in target bacteria that could help them survive, according to a study published today in eLife.

23 Feb 2021

Could laser-facilitated epicutaneous vaccination for SARS-CoV-2 be an alternative to intramuscular injection?

Scientists at the University of Salzburg and Pantec Biosolutions AG have developed a laser-facilitated epicutaneous immunization against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. The model has induced angiotensin-converting enzyme 2 (ACE2) blocking antibodies in mice.

23 Feb 2021

Vaccine candidate containing tetanus toxoid potentially protective against SARS-CoV-2

Researchers from Cuba, China, and France have demonstrated the potential of coupling a viral antigen with the tetanus toxoid protein as a vaccination approach to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

14 Feb 2021

The Future of Environmental and Food Monitoring

NewsMed interviews Professor Antje Baeumner about the future of food and environmental monitoring, the subject of her 2021 Pittcon presentation.

From Pittcon 12 Feb 2021

Pandemic-fueled alcohol abuse creates wave of hospitalizations for liver disease

As the pandemic sends thousands of recovering alcoholics into relapse, hospitals across the country have reported dramatic increases in alcohol-related admissions for critical diseases like alcoholic hepatitis and liver failure.

10 Feb 2021

New study describes the evolutionary tale of poisonous butterflies

The Atala butterfly (Eumaeus atala) and its five closest relatives in the genus Eumaeus like to display their toxicity.

8 Feb 2021

Study: Brain hormones could improve metabolism and fight obesity

A mitochondrial hormone expressed by cells deep in the brain appears to play a role in improving metabolism and fighting off obesity, according to a new study in mice.

3 Feb 2021

Scientists create new way to detect COVID-19 proteins and antibodies

Scientists have created a new way to detect the proteins that make up the pandemic coronavirus, as well as antibodies against it. They designed protein-based biosensors that glow when mixed with components of the virus or specific COVID-19 antibodies.

29 Jan 2021

Inflammation may contribute to the persistence of C. diff infection, shows study

A new study from North Carolina State University shows that the inflammation caused by Clostridioides difficile (C. diff) infection gives the pathogen a two-fold advantage: by both creating an inhospitable environment for competing bacteria and providing nutrients that enable C. diff to thrive.

19 Jan 2021

Certain snakes evolve a unique genetic trick to avoid venomous snake-eating snakes

Certain snakes have evolved a unique genetic trick to avoid being eaten by venomous snakes, according to University of Queensland research.

15 Jan 2021

New approach to tame botulinum toxin for drug delivery

While rare, botulism can cause paralysis and is potentially fatal. It is caused by nerve-damaging toxins produced by Clostridium botulinum -- the most potent toxins known.

8 Jan 2021

CytoDel successfully delivers neuronal antibody in animal models of botulism

CytoDel, Inc., a privately-held corporation, today announces the publication of preclinical data on the Company's lead product, Cyto-111, in the peer-reviewed journal, Science Translational Medicine. The complete text of the article titled, "Neuronal Delivery of Antibodies has Therapeutic Effects in Animal Models of Botulism," can be found here.

7 Jan 2021

New approach produces strong antidotal efficacy in treating lethal botulism in animals

Related to new research published in the January issue of Science Translational Medicine, Patrick McNutt, PhD, of the Wake Forest Institute for Regenerative Medicine, was part of the research team that demonstrated a new "Trojan horse" approach that produces strong antidotal efficacy in treating lethal botulism in mice, guinea pigs and rhesus macaque monkeys.

7 Jan 2021

Researchers examine the role of Shiga toxin in the immune system

E. coli food poisoning is one of the worst food poisonings, causing bloody diarrhea and kidney damage. But all the carnage might be just an unintended side effect, researchers from UConn Health report in the 27 November issue of Science Immunology.

7 Jan 2021

Non-toxic versions of botulism toxins can deliver therapeutic antibodies to treat botulism

Taking advantage of the chemical properties of botulism toxins, two teams of researchers have fashioned non-toxic versions of these compounds that can deliver therapeutic antibodies to treat botulism, a potentially fatal disease with few approved treatments.

6 Jan 2021

Gut microbe may play a role in the development of breast cancers

A microbe found in the colon and commonly associated with the development of colitis and colon cancer also may play a role in the development of some breast cancers, according to new research from investigators with the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

6 Jan 2021

Toxin News and Research

UTSW researchers identify the structure of a key cell-surface protein

New approach may lead to novel treatments for renal fibrosis

Diphtheria is evolving to become antibiotic-resistant and could lead to vaccine escape

'Miracle poison' can target a variety of different proteins

Study: Interbacterial toxins may contribute to bacterial genetic diversity

Could laser-facilitated epicutaneous vaccination for SARS-CoV-2 be an alternative to intramuscular injection?

Vaccine candidate containing tetanus toxoid potentially protective against SARS-CoV-2

The Future of Environmental and Food Monitoring

Pandemic-fueled alcohol abuse creates wave of hospitalizations for liver disease

New study describes the evolutionary tale of poisonous butterflies

Study: Brain hormones could improve metabolism and fight obesity

Scientists create new way to detect COVID-19 proteins and antibodies

Inflammation may contribute to the persistence of C. diff infection, shows study

Certain snakes evolve a unique genetic trick to avoid venomous snake-eating snakes

New approach to tame botulinum toxin for drug delivery

CytoDel successfully delivers neuronal antibody in animal models of botulism

New approach produces strong antidotal efficacy in treating lethal botulism in animals

Researchers examine the role of Shiga toxin in the immune system

Non-toxic versions of botulism toxins can deliver therapeutic antibodies to treat botulism

Gut microbe may play a role in the development of breast cancers

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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