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Circular DNA found in cancer cells supports their survival and resistance

A new study uncovers the role of the circular, 3D shape of extrachromosomal DNA in augmenting mutant oncogenes in cancer cells.

20 Nov 2019

Improving the efficiency of antiangiogenic and antifibrotic drug for treatment of lung cancer

The University of Barcelona and Hospital Clínic de Barcelona collaborate with Boehringer Ingelheim Inc. to improve the efficiency of nintedanib, an antiangiogenic and antifibrotic drug, for the treatment of lung cancer.

19 Nov 2019

Scientists develop new therapy for acute myeloid leukemia

Cold Spring Harbor Laboratory scientists, with chemists and cancer biologists from Dana-Farber Cancer Institute, have developed a new therapy that extended the survival of mice with acute myeloid leukemia.

19 Nov 2019

Mining 'darkest' parts of the genome in cancer cells yields gold

Mining the rich uncharted territory of the genome or genetic material of a cancer cell has yielded gold for Princess Margaret scientists: new protein targets for drug development against prostate cancer.

15 Nov 2019

Dopamine D2 receptor modulates Wnt expression, controls cell proliferation

The dopamine D2 receptor has a previously unobserved role in modulating Wnt expression and control of cell proliferation, according to a new study from the George Washington University and the University of Pittsburgh.

14 Nov 2019

Uncovering the secret weapon of rabies viruses

In a new study published in the journal Cell Reports, scientists have discovered the exact site at which the immune system is disabled by the rabies virus, opening the way for a new and highly effective means of rabies prevention. This is a long-awaited discovery and could transform the field of rabies immunization.

13 Nov 2019

Scientists explore expansion of cytotoxic CD4 T-cells in supercentenarians

Scientists from the RIKEN Center for Integrative Medical Science (IMS) and Keio University School of Medicine in Japan have used single-cell RNA analysis to find that supercentenarians--meaning people over the age of 110--have an excess of a type of immune cell called cytotoxic CD4 T-cells.

13 Nov 2019

Scientists find driver for more deadly prostate cancer

A transcription factor that aids neuron function also appears to enable a cell conversion in the prostate gland that can make an already recurrent cancer even more deadly, scientists say.

13 Nov 2019

UAB study suggests potential treatment target for IPF

Long-held dogma says lung fibrosis in diseases like idiopathic pulmonary fibrosis, or IPF, results from recurrent injury to alveolar epithelium that is followed by dysregulated repair.

12 Nov 2019

Fresh light on why aggressive breast tumors form and how they can be treated

New research presented at the Society for Endocrinology annual conference in Brighton appears to identify novel methods of therapy for an aggressive type of breast cancer as well as uncovering potential causative factors. The focus of the study is to show how common chemicals present in our surroundings are possibly putting women at risk of a type of breast cancer called triple negative breast cancer (TNBC).

12 Nov 2019

Collaborative study shows sex-specific processes in schizophrenia and bipolar disorder

Recent studies have found a high genetic similarity of the psychiatric diseases schizophrenia and bipolar disorder, whose disease-specific changes in brain cells show an overlap of more than 70 percent.

12 Nov 2019

Fluorescent carbon dots can effectively detect calcium levels in cells

In hospitals, doctors often advise patients to take calcium supplements. But does the calcium get into the cells that need it? Until recently, it's been hard to tell.

12 Nov 2019

Scientists publish structural and functional keys that distinguish two similar transcription factors

Scientists at the Institute for Research in Biomedicine, in collaboration with the Sloan Kettering Institute (New York, US), have published the structural and functional keys that distinguish two very similar transcription factors, namely SMAD2 and SMAD3.

12 Nov 2019

Preclinical data on new drug combination to treat neuroblastoma published

Neuroblastoma is the most common cancer outside of the brain in infants and young children and often fails to respond to therapy. Though it can appear in several areas of the body, it commonly develops as a solid tumor most frequently found in or adjacent to the adrenal glands, which sit atop the kidneys.

10 Nov 2019

Finding ways to stop cancer at its roots

Why do some cancers come back? Sometimes, a treatment can effectively eliminate cancer cells to undetectable levels, but, if the treatment stops, cancer may return.

7 Nov 2019

Study sheds light on potential strategy for treating Charcot-Marie-Tooth

An unexpected finding from the Scripps Research laboratory of Xiang-Lei Yang, PhD, has illuminated a potential strategy for treating the inherited neurological disease Charcot-Marie-Tooth (CMT), for which there is no approved medicine today.

7 Nov 2019

Study uncovers how cells 'forget their past' while developing into a specific cell

All cells in the body contain the same genetic material. The difference between cells therefore depends solely on which genes are expressed or ‘turned on’.

7 Nov 2019

Researchers find genes from 'fossil' virus in human DNA to be active

Genes from a virus that was stitched into the human genome thousands of years ago are active, producing proteins in the human brain and other tissues, according to researchers at the University of Washington School of Medicine and the Laval University School of Medicine in Quebec, Canada.

5 Nov 2019

Scientists capture elusive cancer-related protein in action

Scientists have for the first time seen how the MYC protein, which plays a central role in cancer, binds to a key protein and controls important functions in the cell.

4 Nov 2019

Study identifies a kinase as potential target to treat heart failure

An unexplored kinase in heart muscle cells may be a good target to treat heart failure, a disease that is only incrementally delayed by existing therapies.

31 Oct 2019